STRINGSTRING
PRKAG1 PRKAG1 NCOA2 NCOA2 ATP5MC2 ATP5MC2 PPARA PPARA CHD9 CHD9 APOO APOO MEF2D MEF2D ESRRA ESRRA ACSS2 ACSS2 PRKAG3 PRKAG3 TBL1XR1 TBL1XR1 TFAM TFAM PERM1 PERM1 IDH2 IDH2 F7G769_MACMU F7G769_MACMU HDAC3 HDAC3 C16H17orf80 C16H17orf80 MAPK12 MAPK12 CREB1 CREB1 F7GMK9_MACMU F7GMK9_MACMU MEF2C MEF2C GABPB2 GABPB2 RXRA RXRA HCFC1 HCFC1 ATF2 ATF2 ENSMMUP00000049207 ENSMMUP00000049207 IMMT IMMT TBL1Y TBL1Y ENSMMUP00000051006 ENSMMUP00000051006 HELZ2 HELZ2 SRFBP1 SRFBP1 DMAC2L DMAC2L NCOA6 NCOA6 PRKAG2 PRKAG2 MTX2 MTX2 TBL1X TBL1X CHCHD3 CHCHD3 PPARGC1A PPARGC1A CHCHD6 CHCHD6 MED1 MED1 CAMK4 CAMK4 ATP5ME ATP5ME POLRMT POLRMT TFB1M TFB1M SIRT4 SIRT4 GLUD1 GLUD1 CARM1 CARM1 NR1D1 NR1D1 CREBBP CREBBP ENSMMUP00000065714 ENSMMUP00000065714 ATP5F1A ATP5F1A NRF1 NRF1 ENSMMUP00000068113 ENSMMUP00000068113 NCOA1 NCOA1 SSBP1 SSBP1 ENSMMUP00000070440 ENSMMUP00000070440 ATP5PB ATP5PB SMARCD3 SMARCD3 MTERF2 MTERF2 TWNK TWNK TMEM11 TMEM11 CYCS CYCS LOC706691 LOC706691 GABPA GABPA APOOL APOOL ATP5MG ATP5MG ATP5MC3 ATP5MC3 TFB2M TFB2M LOC699117 LOC699117 ENSMMUP00000078174 ENSMMUP00000078174 ATP5F1C ATP5F1C SOD2 SOD2 ATP5F1E ATP5F1E PRKAB1 PRKAB1 ATP5F1D ATP5F1D ATP5F1B ATP5F1B NCOR1 NCOR1 GABPB1 GABPB1 LOC707476 LOC707476 DNAJC11 DNAJC11 PPARGC1B PPARGC1B CRTC2 CRTC2 TGS1 TGS1 ALAS1 ALAS1 HSPA9 HSPA9 CRTC1 CRTC1 MAPK14 MAPK14 SIRT3 SIRT3 LOC717595 LOC717595 SIRT5 SIRT5 ATP5PF ATP5PF CRTC3 CRTC3 POLG2 POLG2 ATP5MG-2 ATP5MG-2 PRKAA2 PRKAA2 ATP5PD ATP5PD PRKAB2 PRKAB2 ATP5MC1 ATP5MC1 MAPK11 MAPK11 F7ALL9_MACMU F7ALL9_MACMU SAMM50 SAMM50 MTERF1 MTERF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
NCOA2Nuclear receptor coactivator. (1468 aa)
ATP5MC2ATP synthase membrane subunit c locus 2; Belongs to the ATPase C chain family. (198 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2902 aa)
APOOMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (198 aa)
MEF2DMyocyte-specific enhancer factor 2D. (521 aa)
ESRRAEstrogen related receptor alpha. (506 aa)
ACSS2Uncharacterized protein. (714 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (546 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
PERM1PPARGC1 and ESRR induced regulator, muscle 1. (720 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
F7G769_MACMUCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
C16H17orf80Chromosome 16 C17orf80 homolog. (609 aa)
MAPK12Mitogen-activated protein kinase. (479 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
F7GMK9_MACMUUncharacterized protein. (213 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
GABPB2GA binding protein transcription factor subunit beta 2. (448 aa)
RXRARetinoid X receptor alpha. (620 aa)
HCFC1Host cell factor C1. (1966 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSMMUP00000049207Uncharacterized protein. (95 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (753 aa)
TBL1YUncharacterized protein. (561 aa)
ENSMMUP00000051006MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (137 aa)
HELZ2Helicase with zinc finger 2. (2822 aa)
SRFBP1Serum response factor binding protein 1. (480 aa)
DMAC2LDistal membrane arm assembly complex 2 like. (215 aa)
NCOA6Nuclear receptor coactivator 6. (2065 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
MTX2Metaxin-2. (263 aa)
TBL1XTransducin beta like 1 X-linked. (641 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (232 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (294 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
ATP5MEUncharacterized protein. (221 aa)
POLRMTDNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1228 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (345 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (323 aa)
GLUD1Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
ENSMMUP00000065714Uncharacterized protein. (192 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (623 aa)
NRF1Nuclear respiratory factor 1. (582 aa)
ENSMMUP00000068113Uncharacterized protein. (99 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
SSBP1Uncharacterized protein. (163 aa)
ENSMMUP00000070440Tom37 domain-containing protein. (210 aa)
ATP5PBUncharacterized protein. (290 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (533 aa)
MTERF2Mitochondrial transcription termination factor 2. (385 aa)
TWNKTwinkle protein, mitochondrial isoform A. (684 aa)
TMEM11Transmembrane protein 11, mitochondrial. (192 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC706691ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
GABPAGA-binding protein alpha chain. (454 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (310 aa)
ATP5MGATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (114 aa)
ATP5MC3ATP synthase lipid-binding protein, mitochondrial isoform A; Belongs to the ATPase C chain family. (141 aa)
TFB2MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (396 aa)
LOC699117Uncharacterized protein. (137 aa)
ENSMMUP00000078174Uncharacterized protein. (480 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ATP5F1EH+ transporting F1 ATP synthase epsilon subunit. (51 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ATP5F1DATP synthase subunit delta, mitochondrial. (168 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
GABPB1ANK_REP_REGION domain-containing protein. (399 aa)
LOC707476ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (135 aa)
DNAJC11DnaJ heat shock protein family (Hsp40) member C11. (587 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
CRTC2CREB-regulated transcription coactivator 2. (694 aa)
TGS1Trimethylguanosine synthase 1. (855 aa)
ALAS15-aminolevulinate synthase. (640 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform 3. (650 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
LOC717595Metaxin 1. (466 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] (348 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (116 aa)
CRTC3CREB regulated transcription coactivator 3. (803 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
ATP5MG-2Uncharacterized protein. (77 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
ATP5MC1ATP synthase lipid-binding protein, mitochondrial; Belongs to the ATPase C chain family. (135 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
F7ALL9_MACMUUncharacterized protein. (256 aa)
SAMM50SAMM50 sorting and assembly machinery component. (497 aa)
MTERF1Mitochondrial transcription termination factor 1. (430 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (20%) [HD]