STRINGSTRING
KCNS3 KCNS3 KCNC2 KCNC2 ITPR2 ITPR2 ADRA2C ADRA2C KCNG2 KCNG2 MARCKS MARCKS ITPR3 ITPR3 ADRA2A ADRA2A ADCY8 ADCY8 CACNB3 CACNB3 STX1A STX1A ITPR1 ITPR1 GNGT1 GNGT1 ADCY3 ADCY3 SYT5 SYT5 PPP2R1B PPP2R1B CACNA1D CACNA1D GNG11 GNG11 MLXIPL MLXIPL GNG3 GNG3 ACLY ACLY CACNA2D1 CACNA2D1 AKAP5 AKAP5 ADCY5 ADCY5 RAPGEFL1 RAPGEFL1 GCGR GCGR RAPGEF4 RAPGEF4 PRKACA PRKACA SLC2A1 SLC2A1 ADIPOQ ADIPOQ PRKAG2 PRKAG2 RAPGEF3 RAPGEF3 ADCY2 ADCY2 PRKACB PRKACB PPP2R5D PPP2R5D GNAQ GNAQ SNAP25 SNAP25 GNA15 GNA15 GNG4 GNG4 ADCY6 ADCY6 ADIPOR1 ADIPOR1 GNB1 GNB1 AGPAT1 AGPAT1 GNG7 GNG7 PLCB2 PLCB2 ADCY9 ADCY9 ADCY1 ADCY1 PRKCA PRKCA RAP1A RAP1A ACACB ACACB GNB2 GNB2 GCG GCG CD36 CD36 TALDO1 TALDO1 ADCY7 ADCY7 PRKAR1B PRKAR1B ACSL3 ACSL3 PRKAR1A PRKAR1A FFAR1 FFAR1 PKLR PKLR SLC2A2 SLC2A2 MLXIP MLXIP INS INS RAPGEF5 RAPGEF5 ABCC8 ABCC8 GLP1R GLP1R AHCYL1 AHCYL1 STK11 STK11 GNG5 GNG5 PFKFB1 PFKFB1 PPP2R1A PPP2R1A PPP2CB PPP2CB ADCY4 ADCY4 THAP7 THAP7 PRKACG PRKACG GNAI2 GNAI2 GNB5 GNB5 ADIPOR2 ADIPOR2 GNA14 GNA14 STXBP1 STXBP1 PRKAR2B PRKAR2B CACNA1E CACNA1E TKT TKT TKTL1 TKTL1 CACNA1C CACNA1C PLCB3 PLCB3 FASN FASN PRKAB2 PRKAB2 IQGAP1 IQGAP1 PRKAA2 PRKAA2 LOC694289 LOC694289 MLX MLX ACACA ACACA CNBD2 CNBD2 THAP6 THAP6 CACNA1F CACNA1F CACNB2 CACNB2 CACNA2D2 CACNA2D2 KCNB1 KCNB1 GNB3 GNB3 PLCB1 PLCB1 ACSL4 ACSL4 GNB4 GNB4 CACNA1A CACNA1A TKTL2 TKTL2 FAP FAP GNA11 GNA11 GNG13 GNG13 PRKAR2A PRKAR2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2 isoform KV3.2b; Belongs to the potassium channel family. (638 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ADRA2CAdrenoceptor alpha 2C. (458 aa)
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (467 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (331 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CACNB3SH3 domain-containing protein. (498 aa)
STX1ASyntaxin-1A isoform 1; Belongs to the syntaxin family. (288 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
SYT5Synaptotagmin 5. (386 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
MLXIPLMLX interacting protein like. (880 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1155 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (667 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1047 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
GNA15Uncharacterized protein. (414 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (307 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ACACBAcetyl-CoA carboxylase beta. (2486 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GCGGlucagon. (263 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (599 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PRKAR1BCyclic nucleotide-binding domain-containing protein. (494 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
FFAR1Uncharacterized protein. (300 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
MLXIPMLX interacting protein. (986 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (883 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
AHCYL1Putative adenosylhomocysteinase 2 isoform a; Belongs to the adenosylhomocysteinase family. (530 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (522 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
THAP7THAP domain-containing protein 7 isoform 2. (309 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
GNB5G protein subunit beta 5. (395 aa)
ADIPOR2Adiponectin receptor 2. (406 aa)
GNA14G protein subunit alpha 14. (355 aa)
STXBP1Syntaxin-binding protein 1 isoform a; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2412 aa)
TKTTransketolase. (623 aa)
TKTL1Transketolase-like protein 1 isoform a. (596 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
FASNFatty acid synthase. (2576 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1667 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
LOC694289Uncharacterized protein. (394 aa)
MLXMAX dimerization protein MLX. (298 aa)
ACACAAcetyl-CoA carboxylase alpha. (2332 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (532 aa)
THAP6THAP domain containing 6. (282 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1970 aa)
CACNB2SH3 domain-containing protein. (660 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1153 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ACSL4Long-chain-fatty-acid--CoA ligase 4 isoform 2. (711 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
TKTL2Transketolase like 2. (626 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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