STRINGSTRING
MAP3K8 MAP3K8 LY96 LY96 NFKB2 NFKB2 TONSL TONSL MAPK15 MAPK15 MAPK9 MAPK9 RELCH RELCH ENSMMUP00000079334 ENSMMUP00000079334 NLRC5 NLRC5 FNBP4 FNBP4 S100B S100B S100A12 S100A12 LOC699403 LOC699403 NKIRAS1 NKIRAS1 DUSP3 DUSP3 ATF7 ATF7 VRK3 VRK3 MAPKAPK3 MAPKAPK3 MFSD3 MFSD3 BIRC2 BIRC2 JUN JUN PPP4R1 PPP4R1 DUSP4 DUSP4 FOS FOS BIRC3 BIRC3 ENSMMUP00000071311 ENSMMUP00000071311 ENSMMUP00000070235 ENSMMUP00000070235 KHNYN KHNYN ENSMMUP00000067421 ENSMMUP00000067421 ATF1 ATF1 DUSP6 DUSP6 TRAF3 TRAF3 CUL1 CUL1 IRAK2 IRAK2 LRRC74B LRRC74B NAIP NAIP HMGB1 HMGB1 LRRC71 LRRC71 SARM1 SARM1 BIRC7 BIRC7 FADD FADD PPP2R5D PPP2R5D MAP2K6 MAP2K6 TAB3 TAB3 TANK TANK RELA RELA MEF2A MEF2A SKP1-2 SKP1-2 NFKBIA NFKBIA VWC2 VWC2 MAPK3 MAPK3 RPS6KA3 RPS6KA3 UBE2N UBE2N CCDC71L CCDC71L UBB UBB BTRC BTRC PTPN11 PTPN11 FBXW11 FBXW11 PPP2R1B PPP2R1B ATF2 ATF2 RPS6KA2 RPS6KA2 USP14 USP14 NOD2 NOD2 UBC UBC NLRP6 NLRP6 MAP2K4 MAP2K4 CHUK CHUK KXD1 KXD1 NKIRAS2 NKIRAS2 MEF2C MEF2C RPS6KA5 RPS6KA5 MAPK10 MAPK10 CREB5 CREB5 LOC114672301 LOC114672301 TNIP2 TNIP2 IKBKG IKBKG TLR4 TLR4 HMGB1-2 HMGB1-2 TRAF5 TRAF5 IKBKE IKBKE CASP8 CASP8 CREB1 CREB1 MAP2K3 MAP2K3 NFKB1 NFKB1 MAP3K7 MAP3K7 NLRP9 NLRP9 IKBKB IKBKB RIPK2 RIPK2 NFKBIB NFKBIB MAPKAPK2 MAPKAPK2 LRRC74A LRRC74A IRF3 IRF3 CREM CREM RPS6KA1 RPS6KA1 PPP2R1A PPP2R1A LRRC31 LRRC31 LRRC34 LRRC34 PPP4R4 PPP4R4 PPP2CB PPP2CB CISD1 CISD1 ELK1 ELK1 N4BP1 N4BP1 IRAK1 IRAK1 AGER AGER TRAF6 TRAF6 MAP2K1 MAP2K1 NLRP13 NLRP13 UBA52 UBA52 TIFA TIFA RPS27A-2 RPS27A-2 TMED7 TMED7 TAB2 TAB2 FOSL2 FOSL2 APP APP SAA1 SAA1 MAPK11 MAPK11 ALPK1 ALPK1 RPS27A RPS27A NOD1 NOD1 MAPK1 MAPK1 NLRX1 NLRX1 TAB1 TAB1 TRAF2 TRAF2 SAA2 SAA2 SAA4 SAA4 LRRC45 LRRC45 MAP3K20 MAP3K20 CD14 CD14 TP53 TP53 MAPK7 MAPK7 RIPK1 RIPK1 MAPK14 MAPK14 TBK1 TBK1 IRF7 IRF7 DUSP7 DUSP7 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (572 aa)
LY96MD2 protein. (160 aa)
NFKB2Nuclear factor kappa B subunit 2. (907 aa)
TONSLTonsoku like, DNA repair protein. (1377 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
ENSMMUP00000079334Uncharacterized protein. (295 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
FNBP4Formin binding protein 4. (1013 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa)
LOC699403WRNPLPNID domain-containing protein. (964 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (243 aa)
DUSP3Tyrosine-protein phosphatase domain-containing protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (374 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
VRK3VRK serine/threonine kinase 3. (482 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa)
MFSD3Uncharacterized protein. (502 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (933 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
ENSMMUP00000071311UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (225 aa)
ENSMMUP00000070235Ubiquitin-like domain-containing protein. (110 aa)
KHNYNKH and NYN domain containing. (678 aa)
ENSMMUP00000067421Ubiquitin-like domain-containing protein. (135 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (270 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CUL1Cullin 1; Belongs to the cullin family. (809 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (666 aa)
LRRC74BUncharacterized protein. (238 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
HMGB1High mobility group box 1. (215 aa)
LRRC71Leucine rich repeat containing 71. (559 aa)
SARM1Sterile alpha and TIR motif-containing protein 1. (724 aa)
BIRC7Baculoviral IAP repeat containing 7. (410 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
TAB3Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform a. (425 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform 2. (503 aa)
SKP1-2Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RPS6KA3Ribosomal protein S6 kinase. (755 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
CCDC71LCoiled-coil domain containing 71 like. (235 aa)
UBBUncharacterized protein. (229 aa)
BTRCUncharacterized protein. (629 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FBXW11Uncharacterized protein. (563 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
UBCUncharacterized protein. (270 aa)
NLRP6Uncharacterized protein. (1044 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KXD1KxDL domain-containing protein. (231 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
LOC114672301ETS domain-containing protein. (488 aa)
TNIP2TNFAIP3 interacting protein 2. (468 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
HMGB1-2High mobility group protein B1. (214 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
NFKB1Uncharacterized protein. (977 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
NLRP9Uncharacterized protein. (992 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
NFKBIBNF-kappa-B inhibitor beta isoform a. (356 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
LRRC74ALeucine rich repeat containing 74A. (524 aa)
IRF3Interferon regulatory factor 3. (450 aa)
CREMcAMP responsive element modulator. (295 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
LRRC31Leucine rich repeat containing 31. (578 aa)
LRRC34Leucine rich repeat containing 34. (464 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (872 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CISD1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (725 aa)
AGERUncharacterized protein. (403 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NLRP13NLR family pyrin domain containing 13. (1044 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (185 aa)
RPS27A-2Ubiquitin-40S ribosomal protein S27a. (156 aa)
TMED7Uncharacterized protein; Belongs to the EMP24/GP25L family. (404 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ALPK1Alpha kinase 1. (1245 aa)
RPS27AUncharacterized protein. (156 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NLRX1NLR family member X1. (972 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
SAA2Amyloid protein A; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
SAA4Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (822 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
IRF7Interferon regulatory factor 7. (504 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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