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| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1508 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | ENSMMUP00000079334 | Uncharacterized protein. (295 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | TLR1 | Toll-like receptor. (786 aa) |
| | FNBP4 | Formin binding protein 4. (1013 aa) |
| | S100B | Protein S100; Belongs to the S-100 family. (92 aa) |
| | LOC100425060 | Uncharacterized protein. (410 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa) |
| | LOC699403 | WRNPLPNID domain-containing protein. (964 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (243 aa) |
| | DUSP3 | Tyrosine-protein phosphatase domain-containing protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (374 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (482 aa) |
| | LOC114669832 | Uncharacterized protein. (410 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa) |
| | MFSD3 | Uncharacterized protein. (502 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (933 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | FOS | V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa) |
| | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) |
| | ENSMMUP00000070235 | Ubiquitin-like domain-containing protein. (110 aa) |
| | ECSIT | ECSIT signalling integrator. (467 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | ENSMMUP00000067421 | Ubiquitin-like domain-containing protein. (135 aa) |
| | ATF1 | Cyclic AMP-dependent transcription factor ATF-1. (270 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (809 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (666 aa) |
| | LRRC74B | Uncharacterized protein. (238 aa) |
| | HMGB1 | High mobility group box 1. (215 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | TAB3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa) |
| | S100A1 | S100 calcium binding protein A1; Belongs to the S-100 family. (97 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A isoform 2. (503 aa) |
| | SKP1-2 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (755 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | CCDC71L | Coiled-coil domain containing 71 like. (235 aa) |
| | UBB | Uncharacterized protein. (229 aa) |
| | BTRC | Uncharacterized protein. (629 aa) |
| | FBXW11 | Uncharacterized protein. (563 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (716 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | UBC | Uncharacterized protein. (270 aa) |
| | NLRP6 | Uncharacterized protein. (1044 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | KXD1 | KxDL domain-containing protein. (231 aa) |
| | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C isoform 1. (473 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | LOC114672301 | ETS domain-containing protein. (488 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (468 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | HMGB1-2 | High mobility group protein B1. (214 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | MAP2K3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | NLRP9 | Uncharacterized protein. (992 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | NFKBIB | NF-kappa-B inhibitor beta isoform a. (356 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (524 aa) |
| | CREM | cAMP responsive element modulator. (295 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa) |
| | LRRC31 | Leucine rich repeat containing 31. (578 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | FGG | Fibrinogen gamma chain. (437 aa) |
| | FGA | Fibrinogen alpha chain. (928 aa) |
| | FGB | Fibrinogen beta chain. (491 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (872 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ELK1 | ETS domain-containing protein Elk-1. (428 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | AGER | Uncharacterized protein. (403 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1044 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40. (128 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TIFA | TRAF-interacting protein with FHA domain-containing protein A. (185 aa) |
| | RPS27A-2 | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (326 aa) |
| | APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa) |
| | SAA1 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | ALPK1 | Alpha kinase 1. (1245 aa) |
| | RPS27A | Uncharacterized protein. (156 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NLRX1 | NLR family member X1. (972 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | SAA2 | Amyloid protein A; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | SAA4 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (822 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (572 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | LY96 | MD2 protein. (160 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (907 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1377 aa) |
| | TLR6 | Toll-like receptor. (796 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
