STRINGSTRING
NOS3 NOS3 SHF SHF HSP90AA1 HSP90AA1 FYN FYN LOC704609 LOC704609 PAK3 PAK3 CYFIP1 CYFIP1 NCKAP1L NCKAP1L PRKCD PRKCD HSPB1 HSPB1 WASF2 WASF2 MAPKAPK3 MAPKAPK3 CYBB CYBB STX7 STX7 MTOR MTOR VAV3 VAV3 SHC2 SHC2 CYBA CYBA TENM4 TENM4 PRKCA PRKCA BCAR1 BCAR1 NCKAP1 NCKAP1 NCK1 NCK1 CTNNB1 CTNNB1 WASF3 WASF3 WASF1 WASF1 PRKCB PRKCB NCF4 NCF4 HSH2D HSH2D AKT1 AKT1 CAV3 CAV3 PRKACB PRKACB AKT2 AKT2 VAV1 VAV1 PXN PXN PGF PGF SZRD1 SZRD1 PLCG1 PLCG1 ELMO3 ELMO3 SHD SHD TENM1 TENM1 BAIAP2 BAIAP2 PRKACA PRKACA SH2D2A SH2D2A ACTB ACTB NRAS NRAS PTK2 PTK2 ACTRT1 ACTRT1 TGFB1I1 TGFB1I1 ROCK1 ROCK1 ITPR1 ITPR1 RHOA RHOA MAPK13 MAPK13 SPHK1 SPHK1 BRK1 BRK1 ACTG1 ACTG1 ITPR3 ITPR3 NCF2 NCF2 CRK CRK AXL AXL NEDD9 NEDD9 CDC42 CDC42 ITPR2 ITPR2 MAPKAP1 MAPKAP1 CTNND1 CTNND1 MAPK12 MAPK12 ROCK2 ROCK2 FNDC3A FNDC3A NCK2 NCK2 NRP1 NRP1 TENM2 TENM2 CDH5 CDH5 MAPKAPK2 MAPKAPK2 ELMO1 ELMO1 SHE SHE AAMP AAMP AHCYL1 AHCYL1 HRAS HRAS FLT1 FLT1 PRKACG PRKACG SRC SRC NRP2 NRP2 AKT3 AKT3 ITGAV ITGAV ACTL7A ACTL7A ACTL7B ACTL7B MLST8 MLST8 PTK2B PTK2B PRKCZ PRKCZ PAK1 PAK1 FLT4 FLT4 DOCK1 DOCK1 CTNNA1 CTNNA1 VAV2 VAV2 ARVCF ARVCF ERAS ERAS VEGFD VEGFD ELMO2 ELMO2 EFS EFS CAV1 CAV1 MAPK11 MAPK11 JUP JUP VEGFB VEGFB KDR KDR TRIB3 TRIB3 ACTRT2 ACTRT2 PAK2 PAK2 LPXN LPXN PIK3R1 PIK3R1 PDPK1 PDPK1 F7B371_MACMU F7B371_MACMU CYFIP2 CYFIP2 ACTL8 ACTL8 LOC705671 LOC705671 RNF222 RNF222 SHB SHB PIK3CB PIK3CB MAPK14 MAPK14 NCF1 NCF1 TENM3 TENM3 PRR5 PRR5 PIK3CA PIK3CA ABI1 ABI1 VEGFA VEGFA FNDC3B FNDC3B VEGFC VEGFC ITGB3 ITGB3 RASA1 RASA1 PIK3R2 PIK3R2 KRAS KRAS CSDE1 CSDE1 RICTOR RICTOR ACTL9 ACTL9 ABI2 ABI2 CASS4 CASS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SHFSrc homology 2 domain containing F. (488 aa)
HSP90AA1HATPase_c domain-containing protein. (733 aa)
FYNTyrosine-protein kinase. (589 aa)
LOC704609Uncharacterized protein; Belongs to the actin family. (912 aa)
PAK3Uncharacterized protein. (580 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
PRKCDProtein kinase C. (729 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
WASF2WASP family member 2. (498 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa)
CYBBCytochrome b-245 beta chain. (617 aa)
STX7Syntaxin-7; Belongs to the syntaxin family. (261 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
VAV3Vav guanine nucleotide exchange factor 3. (1128 aa)
SHC2Uncharacterized protein. (652 aa)
CYBAUncharacterized protein. (210 aa)
TENM4Teneurin transmembrane protein 4. (2929 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (935 aa)
NCKAP1Nck-associated protein 1 isoform 2. (1134 aa)
NCK1Cytoplasmic protein. (377 aa)
CTNNB1Catenin beta-1. (781 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3. (502 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
NCF4Neutrophil cytosolic factor 4. (366 aa)
HSH2DHematopoietic SH2 domain containing. (475 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
VAV1Vav guanine nucleotide exchange factor 1. (928 aa)
PXNPaxillin. (1167 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
SZRD1SUZ RNA binding domain containing 1. (151 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ELMO3Engulfment and cell motility 3. (771 aa)
SHDSrc homology 2 domain containing transforming protein D. (357 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4. (534 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SH2D2ASH2 domain containing 2A. (399 aa)
ACTBUncharacterized protein. (421 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ACTRT1Actin-related protein T1; Belongs to the actin family. (375 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (485 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
RHOARas homolog family member A. (209 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
SPHK1Sphingosine kinase 1. (470 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform 1. (522 aa)
CTNND1Uncharacterized protein. (968 aa)
MAPK12Mitogen-activated protein kinase. (479 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform 1. (1198 aa)
NCK2Cytoplasmic protein. (393 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TENM2Teneurin transmembrane protein 2. (2653 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
ELMO1Engulfment and cell motility protein 1 isoform 1. (727 aa)
SHESrc homology 2 domain containing E. (495 aa)
AAMPAngio-associated migratory cell protein. (434 aa)
AHCYL1Putative adenosylhomocysteinase 2 isoform a; Belongs to the adenosylhomocysteinase family. (530 aa)
HRASTransforming protein p21. (189 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
SRCTyrosine-protein kinase. (644 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTL7BActin-like-7-beta; Belongs to the actin family. (415 aa)
MLST8MTOR associated protein, LST8 homolog. (479 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PAK1Non-specific serine/threonine protein kinase. (575 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1883 aa)
CTNNA1Uncharacterized protein. (906 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform 1. (878 aa)
ARVCFARVCF delta catenin family member. (1060 aa)
ERASGTPase ERas. (233 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
EFSEmbryonal Fyn-associated substrate. (563 aa)
CAV1Caveolin 1. (303 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
JUPUncharacterized protein. (744 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
F7B371_MACMUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LOC705671Uncharacterized protein. (398 aa)
RNF222RING-type domain-containing protein. (220 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
TENM3Uncharacterized protein. (2699 aa)
PRR5Uncharacterized protein. (379 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ABI1Abl interactor 1 isoform a. (508 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
CSDE1Cold shock domain containing E1. (830 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
ACTL9Uncharacterized protein; Belongs to the actin family. (416 aa)
ABI2Abl interactor 2. (549 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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