STRINGSTRING
SORT1 SORT1 AP1S1 AP1S1 MTSS1 MTSS1 CPD CPD TGOLN2 TGOLN2 ZFYVE19 ZFYVE19 FTL FTL GNS GNS TPD52L2 TPD52L2 MTSS2 MTSS2 AP3B1 AP3B1 AP4S1 AP4S1 HSPA8 HSPA8 LOC703257 LOC703257 AP3B2 AP3B2 CLTA CLTA AP1M1 AP1M1 AP3S2 AP3S2 SNX6 SNX6 DNAJC6 DNAJC6 EEF1E1 EEF1E1 ENSMMUP00000066266 ENSMMUP00000066266 TBRG4 TBRG4 TBC1D8B TBC1D8B CHMP2A CHMP2A TPD52 TPD52 GBF1 GBF1 VAMP8 VAMP8 SH3D19 SH3D19 BLOC1S6 BLOC1S6 CLINT1 CLINT1 AP3S1 AP3S1 HGS HGS RSPH9 RSPH9 SULF2 SULF2 SNAPIN SNAPIN SH3GL2 SH3GL2 DTNBP1 DTNBP1 ARF1 ARF1 BLOC1S4 BLOC1S4 SBSN SBSN ENSMMUP00000077170 ENSMMUP00000077170 ARRB1 ARRB1 PUM1 PUM1 DNASE2B DNASE2B ENSMMUP00000078568 ENSMMUP00000078568 ENSMMUP00000078716 ENSMMUP00000078716 TBC1D8 TBC1D8 TPD52L1 TPD52L1 STX4 STX4 HIP1R HIP1R AP4B1 AP4B1 GOLGB1 GOLGB1 SORCS1 SORCS1 YIPF6 YIPF6 AP4M1 AP4M1 AP1M2 AP1M2 ZFYVE1 ZFYVE1 DNASE2 DNASE2 NAPA NAPA SNX2 SNX2 SULF1 SULF1 BLOC1S3 BLOC1S3 PIK3C2A PIK3C2A SORCS2 SORCS2 AP1B1 AP1B1 TBC1D9B TBC1D9B PICALM PICALM ACBD3 ACBD3 SNX32 SNX32 AP5M1 AP5M1 CLVS2 CLVS2 M6PR M6PR GAK GAK IGF2R IGF2R CTSZ CTSZ NECAP1 NECAP1 TBC1D9 TBC1D9 AP4E1 AP4E1 DNM2 DNM2 APP APP AP1S2 AP1S2 SNAP23 SNAP23 SNX1 SNX1 HCLS1 HCLS1 SNX5 SNX5 CLHC1 CLHC1 AP1G1 AP1G1 CLTC CLTC AP1S3 AP1S3 CLTB CLTB OCRL OCRL CLVS1 CLVS1 SNX9 SNX9 LOC709412 LOC709412 SPAG5 SPAG5 AP1G2 AP1G2 SORCS3 SORCS3 TPD52L3 TPD52L3 TFRC TFRC VAMP7 VAMP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SORT1Sortilin. (878 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
MTSS1MTSS I-BAR domain containing 1. (799 aa)
CPDCarboxypeptidase D. (1378 aa)
TGOLN2Trans-golgi network protein 2. (451 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (469 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
TPD52L2TPD52 like 2. (355 aa)
MTSS2MTSS I-BAR domain containing 2. (849 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1111 aa)
AP4S1Clat_adaptor_s domain-containing protein. (158 aa)
HSPA8Heat shock cognate 71 kDa protein isoform 1; Belongs to the heat shock protein 70 family. (646 aa)
LOC703257ENTH domain-containing protein. (344 aa)
AP3B2AP-3 complex subunit beta. (1112 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (492 aa)
AP3S2Clat_adaptor_s domain-containing protein. (394 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (434 aa)
DNAJC6Uncharacterized protein. (970 aa)
EEF1E1Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (431 aa)
ENSMMUP00000066266Uncharacterized protein. (188 aa)
TBRG4Transforming growth factor beta regulator 4. (647 aa)
TBC1D8BTBC1 domain family member 8B. (1164 aa)
CHMP2ACharged multivesicular body protein 2a. (222 aa)
TPD52Tumor protein D52. (360 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1942 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
SH3D19SH3 domain containing 19. (1069 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (173 aa)
CLINT1Clathrin interactor 1. (647 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (209 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (805 aa)
RSPH9Radial spoke head 9 homolog. (276 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. (948 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (383 aa)
DTNBP1Dystrobrevin binding protein 1. (425 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (217 aa)
BLOC1S4Biogenesis of lysosomal organelles complex 1 subunit 4. (216 aa)
SBSNSuprabasin. (579 aa)
ENSMMUP00000077170Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
ARRB1Arrestin beta 1. (529 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
ENSMMUP00000078568Uncharacterized protein. (1120 aa)
ENSMMUP00000078716Uncharacterized protein. (533 aa)
TBC1D8TBC1 domain family member 8. (1240 aa)
TPD52L1Uncharacterized protein. (209 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (765 aa)
GOLGB1Golgin B1. (3268 aa)
SORCS1Sortilin related VPS10 domain containing receptor 1. (1168 aa)
YIPF6Protein YIPF. (237 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1 isoform 1. (777 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (404 aa)
NAPANSF attachment protein alpha. (374 aa)
SNX2Sorting nexin 2. (526 aa)
SULF1Sulfatase 1. (1120 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (200 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1161 aa)
AP1B1AP complex subunit beta. (949 aa)
TBC1D9BTBC1 domain family member 9B. (1254 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (674 aa)
ACBD3Acyl-CoA binding domain containing 3. (528 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (431 aa)
AP5M1Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (510 aa)
CLVS2Clavesin-2. (327 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (309 aa)
GAKCyclin G associated kinase. (1311 aa)
IGF2RInsulin like growth factor 2 receptor. (2491 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
NECAP1Adaptin ear-binding coat-associated protein 1. (275 aa)
TBC1D9TBC1 domain family member 9. (1266 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
DNM2Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (224 aa)
SNX1Uncharacterized protein. (534 aa)
HCLS1SH3 domain-containing protein. (551 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (586 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform b. (893 aa)
CLVS1Cellular retinaldehyde-binding protein-like protein. (354 aa)
SNX9Sorting nexin. (625 aa)
LOC709412Uncharacterized protein; Belongs to the heat shock protein 70 family. (590 aa)
SPAG5Sperm associated antigen 5. (1195 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1239 aa)
TPD52L3TPD52 like 3. (150 aa)
TFRCTransferrin receptor protein 1. (760 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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