STRINGSTRING
BMI1 BMI1 SUZ12 SUZ12 CDKN2B CDKN2B NPTX1 NPTX1 LOC695427-2 LOC695427-2 H2BU1 H2BU1 H2AC20 H2AC20 MAPK9 MAPK9 HIST1H2BJ HIST1H2BJ AGO4 AGO4 F7FDU7_MACMU F7FDU7_MACMU RING1 RING1 MAPK8 MAPK8 SCML2 SCML2 EZH1 EZH1 TFDP1 TFDP1 MAPK14 MAPK14 TP53 TP53 CDK6 CDK6 H2AFB3 H2AFB3 RBBP4 RBBP4 NME8 NME8 TXNDC8 TXNDC8 TFDP2 TFDP2 MDM4 MDM4 H2BW2 H2BW2 NRK NRK E2F2 E2F2 TNRC6C TNRC6C CDKN2D CDKN2D NPTX2 NPTX2 MAPK1 MAPK1 RNF2 RNF2 RPS27A RPS27A MAPK11 MAPK11 MDM2 MDM2 FOSL2 FOSL2 LOC698767 LOC698767 RPS27A-2 RPS27A-2 UBA52 UBA52 TXN TXN RBBP7 RBBP7 LOC699443 LOC699443 CBX4 CBX4 TFDP3 TFDP3 H2AFJ H2AFJ MAP3K6 MAP3K6 CDKN2C CDKN2C IFNB1 IFNB1 EED EED TNRC6A TNRC6A HIST1H2BA HIST1H2BA TNIK TNIK E2F1 E2F1 MAPKAPK2 MAPKAPK2 CDK4 CDK4 LOC714001 LOC714001 F7C6W4_MACMU F7C6W4_MACMU F6PS34_MACMU F6PS34_MACMU MAP2K3 MAP2K3 MAP4K4 MAP4K4 NME9 NME9 LOC699317 LOC699317 SCMH1 SCMH1 PHC2 PHC2 H2BFWT H2BFWT MAPK10 MAPK10 CBX7 CBX7 H2AFX H2AFX MAP2K4 MAP2K4 E2F3 E2F3 UBC UBC H2AFZ H2AFZ LOC106996511 LOC106996511 HIST1H2AC HIST1H2AC CBX6 CBX6 UBB UBB AGO3 AGO3 LOC710748 LOC710748 HIST1H2BM HIST1H2BM MAP3K5 MAP3K5 MAPK3 MAPK3 H2BC5 H2BC5 LOC114669830 LOC114669830 AGO1 AGO1 H2BE1 H2BE1 ENSMMUP00000058388 ENSMMUP00000058388 LOC696506 LOC696506 MAP2K6 MAP2K6 LOC106995531 LOC106995531 EZH2 EZH2 LOC704104 LOC704104 ENSMMUP00000061681 ENSMMUP00000061681 HIST1H3D HIST1H3D LOC106996511-2 LOC106996511-2 H3C8 H3C8 CBX2 CBX2 LOC696808 LOC696808 KDM6B KDM6B PHC1 PHC1 LOC106996511-3 LOC106996511-3 LOC697115 LOC697115 LOC106996511-4 LOC106996511-4 MINK1 MINK1 LOC696808-2 LOC696808-2 LOC696808-3 LOC696808-3 ENSMMUP00000066392 ENSMMUP00000066392 LOC698105 LOC698105 ENSMMUP00000067421 ENSMMUP00000067421 ENSMMUP00000067674 ENSMMUP00000067674 LOC693939 LOC693939 ENSMMUP00000068277 ENSMMUP00000068277 LOC106996511-5 LOC106996511-5 LOC718280 LOC718280 NPTXR NPTXR MOV10 MOV10 LOC698354 LOC698354 LOC106996511-6 LOC106996511-6 ENSMMUP00000070235 ENSMMUP00000070235 LOC704341 LOC704341 FOS FOS LOC703889 LOC703889 TXNDC2 TXNDC2 LOC693887 LOC693887 MAPKAPK5 MAPKAPK5 LOC708899 LOC708899 LOC106995979 LOC106995979 LOC695323 LOC695323 JUN JUN LOC699110 LOC699110 SCML1 SCML1 MAPKAPK3 MAPKAPK3 LOC100430668 LOC100430668 LOC697721 LOC697721 HIST1H2BO HIST1H2BO CBX8 CBX8 HIST1H2BK HIST1H2BK H2AFV H2AFV LOC695427 LOC695427 LOC697938 LOC697938 H2BC15 H2BC15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMI1RING-type domain-containing protein. (469 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (158 aa)
NPTX1Neuronal pentraxin-1. (432 aa)
LOC695427-2Histone H3; Belongs to the histone H3 family. (136 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HIST1H2BJHistone H2B; Belongs to the histone H2B family. (126 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (979 aa)
F7FDU7_MACMUThioredoxin; Belongs to the thioredoxin family. (105 aa)
RING1E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SCML2Scm polycomb group protein like 2. (701 aa)
EZH1Histone-lysine N-methyltransferase EZH1. (747 aa)
TFDP1Transcription factor. (410 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa)
H2AFB3Histone H2A; Belongs to the histone H2A family. (115 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (437 aa)
NME8NME/NM23 family member 8. (588 aa)
TXNDC8Thioredoxin domain containing 8. (115 aa)
TFDP2Uncharacterized protein. (490 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (495 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
NRKNik related kinase. (1527 aa)
E2F2E2F transcription factor 2. (437 aa)
TNRC6CUBA domain-containing protein. (1928 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
NPTX2Neuronal pentraxin 2. (431 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RNF2E3 ubiquitin-protein ligase RING2. (336 aa)
RPS27AUncharacterized protein. (156 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
LOC698767Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
RPS27A-2Ubiquitin-40S ribosomal protein S27a. (156 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
LOC699443Histone H3; Belongs to the histone H3 family. (136 aa)
CBX4E3 SUMO-protein ligase CBX4. (560 aa)
TFDP3Transcription factor. (406 aa)
H2AFJHistone H2A; Belongs to the histone H2A family. (129 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1294 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
IFNB1Interferon beta 1. (187 aa)
EEDEmbryonic ectoderm development. (466 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1968 aa)
HIST1H2BAHistone H2B; Belongs to the histone H2B family. (127 aa)
TNIKTRAF2 and NCK interacting kinase. (1311 aa)
E2F1E2F transcription factor 1. (437 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LOC714001Histone H2B; Belongs to the histone H2B family. (126 aa)
F7C6W4_MACMUHistone H2A; Belongs to the histone H2A family. (166 aa)
F6PS34_MACMUHistone H2A; Belongs to the histone H2A family. (169 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4 isoform 5. (1326 aa)
NME9NME/NM23 family member 9; Belongs to the NDK family. (330 aa)
LOC699317Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
SCMH1Scm polycomb group protein homolog 1. (670 aa)
PHC2Polyhomeotic homolog 2. (859 aa)
H2BFWTHistone domain-containing protein; Belongs to the histone H2B family. (164 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CBX7Chromo domain-containing protein. (251 aa)
H2AFXHistone H2A; Belongs to the histone H2A family. (143 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
E2F3E2F transcription factor 3. (465 aa)
UBCUncharacterized protein. (270 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
LOC106996511Histone H4. (103 aa)
HIST1H2ACHistone H2A; Belongs to the histone H2A family. (130 aa)
CBX6Chromobox 6. (419 aa)
UBBUncharacterized protein. (229 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
LOC710748Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H2BMHistone H2B; Belongs to the histone H2B family. (126 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC114669830Histone H3; Belongs to the histone H3 family. (136 aa)
AGO1Protein argonaute-1; Belongs to the argonaute family. (857 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSMMUP00000058388Thioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC696506Histone H2B; Belongs to the histone H2B family. (126 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
LOC106995531Histone H2A-Bbd type 2/3-like. (115 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
LOC704104Histone domain-containing protein. (154 aa)
ENSMMUP00000061681Transcription factor. (409 aa)
HIST1H3DHistone cluster 1, H3d. (136 aa)
LOC106996511-2Histone H4. (103 aa)
H3C8H3 clustered histone 8. (136 aa)
CBX2Chromobox 2. (555 aa)
LOC696808Histone H2B type 1. (126 aa)
KDM6BLysine demethylase 6B. (1677 aa)
PHC1Uncharacterized protein. (1019 aa)
LOC106996511-3Histone H4. (103 aa)
LOC697115Histone H4. (103 aa)
LOC106996511-4Histone H4. (103 aa)
MINK1Misshapen like kinase 1. (1369 aa)
LOC696808-2Histone H2B type 1. (126 aa)
LOC696808-3Histone H2B type 1. (126 aa)
ENSMMUP00000066392annotation not available (136 aa)
LOC698105Histone H3.1. (136 aa)
ENSMMUP00000067421Ubiquitin-like domain-containing protein. (135 aa)
ENSMMUP00000067674Uncharacterized protein. (87 aa)
LOC693939Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMMUP00000068277Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106996511-5Histone H4. (103 aa)
LOC718280Histone domain-containing protein. (136 aa)
NPTXRNeuronal pentraxin receptor. (500 aa)
MOV10Putative helicase MOV-10. (1003 aa)
LOC698354Histone H4. (103 aa)
LOC106996511-6Histone H4. (103 aa)
ENSMMUP00000070235Ubiquitin-like domain-containing protein. (110 aa)
LOC704341Histone H4. (103 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
LOC703889Histone H3.1. (136 aa)
TXNDC2Thioredoxin domain containing 2. (328 aa)
LOC693887Histone H3.3. (136 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform 1. (471 aa)
LOC708899Histone H3.3. (136 aa)
LOC106995979Histone-binding protein RBBP4 isoform a. (425 aa)
LOC695323Histone H4. (103 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
LOC699110Histone H4. (103 aa)
SCML1Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity); Belongs to the SCM family. (343 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa)
LOC100430668Histone H3.1. (136 aa)
LOC697721Histone H4. (103 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
CBX8Chromobox 8. (539 aa)
HIST1H2BKHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (138 aa)
LOC695427Histone H3.1. (136 aa)
LOC697938WD_REPEATS_REGION domain-containing protein. (425 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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