Your Input: | |
| | RING1 | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa) |
| | F7EBI3_MACMU | UBIQUITIN_CONJUGAT_2 domain-containing protein. (189 aa) |
| | F7FDU7_MACMU | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (979 aa) |
| | HIST1H2BJ | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | ANAPC2 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | CDC23 | Cell division cycle protein 23 homolog. (597 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC695427-2 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | NPTX1 | Neuronal pentraxin-1. (432 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (158 aa) |
| | SUZ12 | SUZ12 polycomb repressive complex 2 subunit. (739 aa) |
| | BMI1 | RING-type domain-containing protein. (469 aa) |
| | TNRC6C | UBA domain-containing protein. (1928 aa) |
| | LOC699443 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | CBX4 | E3 SUMO-protein ligase CBX4. (560 aa) |
| | UBE2S | Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | TFDP3 | Transcription factor. (406 aa) |
| | TLX1 | T cell leukemia homeobox 1. (330 aa) |
| | EP400 | E1A binding protein p400. (3045 aa) |
| | H2AFJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | MAP3K6 | Mitogen-activated protein kinase kinase kinase 6. (1294 aa) |
| | CDC27 | Cell division cycle protein 27 homolog isoform 1. (830 aa) |
| | CDKN2C | Cyclin-dependent kinase 4 inhibitor C. (168 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | HMGA1 | High mobility group AT-hook 1. (450 aa) |
| | EHMT1 | Uncharacterized protein. (1298 aa) |
| | EED | Embryonic ectoderm development. (466 aa) |
| | CISD1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (514 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | TNRC6A | Trinucleotide repeat containing adaptor 6A. (1968 aa) |
| | POT1 | Protection of telomeres 1. (658 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (548 aa) |
| | LOC714349 | Ubiquitin-conjugating enzyme E2 C isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | H1-3 | Histone H1.3. (221 aa) |
| | HIST1H2BA | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | TNIK | TRAF2 and NCK interacting kinase. (1311 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (426 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | LOC714001 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | F7C6W4_MACMU | Histone H2A; Belongs to the histone H2A family. (166 aa) |
| | F6PS34_MACMU | Histone H2A; Belongs to the histone H2A family. (169 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MAP2K3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (981 aa) |
| | CDC16 | Cell division cycle protein 16 homolog. (620 aa) |
| | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 isoform 5. (1326 aa) |
| | FAM89B | Uncharacterized protein. (176 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5 isoform a. (755 aa) |
| | NME9 | NME/NM23 family member 9; Belongs to the NDK family. (330 aa) |
| | LOC699317 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | SCMH1 | Scm polycomb group protein homolog 1. (670 aa) |
| | PHC2 | Polyhomeotic homolog 2. (859 aa) |
| | H2BFWT | Histone domain-containing protein; Belongs to the histone H2B family. (164 aa) |
| | CABIN1 | Calcineurin binding protein 1. (2431 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C. (179 aa) |
| | CCNA1 | Cyclin-A1 isoform a; Belongs to the cyclin family. (465 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | CBX7 | Chromo domain-containing protein. (251 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1266 aa) |
| | H2AFX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | ERF | ETS domain-containing protein. (559 aa) |
| | KXD1 | KxDL domain-containing protein. (231 aa) |
| | DBX1 | Developing brain homeobox 1. (344 aa) |
| | STAT3 | Signal transducer and activator of transcription. (871 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | UBC | Uncharacterized protein. (270 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | H2AFZ | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC106996511 | Histone H4. (103 aa) |
| | HMGA2 | High mobility group AT-hook 2. (147 aa) |
| | HIST1H2AC | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | RB1 | Retinoblastoma-associated protein. (928 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1411 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (344 aa) |
| | CBX6 | Chromobox 6. (419 aa) |
| | UBB | Uncharacterized protein. (229 aa) |
| | TM7SF3 | Transmembrane 7 superfamily member 3. (570 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | LOC710748 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ETV3 | ETS translocation variant 3 isoform 1. (511 aa) |
| | HIST1H2BM | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (755 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1483 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | LOC114669830 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | NEDD8 | TERF1 interacting nuclear factor 2. (482 aa) |
| | TLX2 | T cell leukemia homeobox 2. (284 aa) |
| | AGO1 | Protein argonaute-1; Belongs to the argonaute family. (857 aa) |
| | LMNB1 | Lamin-B1 isoform 1; Belongs to the intermediate filament family. (586 aa) |
| | H2BE1 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | ENSMMUP00000058388 | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | LOC696506 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | LOC106995531 | Histone H2A-Bbd type 2/3-like. (115 aa) |
| | LOC698693 | Histone H1.0. (194 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa) |
| | UBN1 | Uncharacterized protein. (1143 aa) |
| | LOC704104 | Histone domain-containing protein. (154 aa) |
| | ENSMMUP00000061681 | Transcription factor. (409 aa) |
| | HIST1H3D | Histone cluster 1, H3d. (136 aa) |
| | LOC106996511-2 | Histone H4. (103 aa) |
| | BARX2 | Homeobox domain-containing protein. (279 aa) |
| | H3C8 | H3 clustered histone 8. (136 aa) |
| | DBX2 | Developing brain homeobox 2. (451 aa) |
| | CBX2 | Chromobox 2. (555 aa) |
| | LOC696808 | Histone H2B type 1. (126 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | HIRA | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1096 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | KDM6B | Lysine demethylase 6B. (1677 aa) |
| | PHC1 | Uncharacterized protein. (1019 aa) |
| | LOC106996511-3 | Histone H4. (103 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B. (198 aa) |
| | LOC697115 | Histone H4. (103 aa) |
| | LOC106996511-4 | Histone H4. (103 aa) |
| | ENSMMUP00000065918 | Uncharacterized protein. (117 aa) |
| | MINK1 | Misshapen like kinase 1. (1369 aa) |
| | LOC696808-2 | Histone H2B type 1. (126 aa) |
| | LOC696808-3 | Histone H2B type 1. (126 aa) |
| | ENSMMUP00000066392 | annotation not available (136 aa) |
| | H1-1 | Histone H1.1. (215 aa) |
| | ENSMMUP00000066500 | Uncharacterized protein. (236 aa) |
| | LOC698105 | Histone H3.1. (136 aa) |
| | ENSMMUP00000067421 | Ubiquitin-like domain-containing protein. (135 aa) |
| | ENSMMUP00000067674 | Uncharacterized protein. (87 aa) |
| | H1-5 | Histone H1a. (226 aa) |
| | ENSMMUP00000067976 | Uncharacterized protein. (120 aa) |
| | ENSMMUP00000068054 | Uncharacterized protein. (102 aa) |
| | LOC693939 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMMUP00000068277 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC106996511-5 | Histone H4. (103 aa) |
| | LOC718280 | Histone domain-containing protein. (136 aa) |
| | NPTXR | Neuronal pentraxin receptor. (500 aa) |
| | MOV10 | Putative helicase MOV-10. (1003 aa) |
| | LOC698354 | Histone H4. (103 aa) |
| | LOC106996511-6 | Histone H4. (103 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (2016 aa) |
| | ENSMMUP00000070232 | Uncharacterized protein. (121 aa) |
| | ENSMMUP00000070235 | Ubiquitin-like domain-containing protein. (110 aa) |
| | LOC704341 | Histone H4. (103 aa) |
| | FOS | V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa) |
| | ANAPC15-2 | Uncharacterized protein. (140 aa) |
| | LMNB2 | Lamin B2; Belongs to the intermediate filament family. (628 aa) |
| | LOC703889 | Histone H3.1. (136 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (599 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | TXNDC2 | Thioredoxin domain containing 2. (328 aa) |
| | LOC693887 | Histone H3.3. (136 aa) |
| | MAPKAPK5 | MAP kinase-activated protein kinase 5 isoform 1. (471 aa) |
| | LOC708899 | Histone H3.3. (136 aa) |
| | LOC106995979 | Histone-binding protein RBBP4 isoform a. (425 aa) |
| | CMC4 | Uncharacterized protein. (92 aa) |
| | LOC695323 | Histone H4. (103 aa) |
| | BARHL2 | BarH like homeobox 2. (356 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | ETV3L | ETS variant 3 like. (360 aa) |
| | LOC699110 | Histone H4. (103 aa) |
| | SCML1 | Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity); Belongs to the SCM family. (343 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa) |
| | ENSMMUP00000075843 | Uncharacterized protein. (341 aa) |
| | LOC100430668 | Histone H3.1. (136 aa) |
| | TLX3 | T cell leukemia homeobox 3. (338 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26. (85 aa) |
| | VENTX | VENT homeobox. (260 aa) |
| | NKX1-1 | NK1 homeobox 1. (448 aa) |
| | NKX1-2 | NK1 homeobox 2. (309 aa) |
| | LOC697721 | Histone H4. (103 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CBX8 | Chromobox 8. (539 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | ENSMMUP00000077734 | Uncharacterized protein. (122 aa) |
| | HLX | H2.0 like homeobox. (495 aa) |
| | SP1 | Uncharacterized protein. (845 aa) |
| | HIST1H1T | Histone H1t; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. (208 aa) |
| | PWWP2A | PWWP domain containing 2A. (755 aa) |
| | HIST1H2BK | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AFV | Histone H2A; Belongs to the histone H2A family. (138 aa) |
| | BARHL1 | BarH like homeobox 1. (327 aa) |
| | ENSMMUP00000080573 | Uncharacterized protein. (121 aa) |
| | LOC695427 | Histone H3.1. (136 aa) |
| | LOC697938 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ERFL | ETS domain-containing protein. (581 aa) |
| | CDKN2D | Cyclin-dependent kinase 4 inhibitor D. (166 aa) |
| | NPTX2 | Neuronal pentraxin 2. (431 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ANAPC11 | Uncharacterized protein. (192 aa) |
| | RNF2 | E3 ubiquitin-protein ligase RING2. (336 aa) |
| | RPS27A | Uncharacterized protein. (156 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | ASF1B | Anti-silencing function 1B histone chaperone. (202 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (326 aa) |
| | LOC698767 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | RPS27A-2 | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | ANAPC16 | Anaphase-promoting complex subunit 16 isoform 1. (110 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40. (128 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | NRK | Nik related kinase. (1527 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (153 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (495 aa) |
| | TFDP2 | Uncharacterized protein. (490 aa) |
| | SRCAP | Helicase SRCAP. (3229 aa) |
| | TXNDC8 | Thioredoxin domain containing 8. (115 aa) |
| | NME8 | NME/NM23 family member 8. (588 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (437 aa) |
| | CCNA2 | Cyclin-A2; Belongs to the cyclin family. (432 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (455 aa) |
| | H2AFB3 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (822 aa) |
| | ASF1A | Histone chaperone ASF1A. (204 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (184 aa) |
| | BARX1 | BARX homeobox 1. (254 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (447 aa) |
| | EZH1 | Histone-lysine N-methyltransferase EZH1. (747 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (400 aa) |
| | SCML2 | Scm polycomb group protein like 2. (701 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | ID1 | DNA-binding protein inhibitor ID-1 isoform a. (154 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | GPR83 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (778 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
