STRINGSTRING
WNT6 WNT6 PTH PTH SHH SHH FZD3 FZD3 FZD9 FZD9 GHRHR GHRHR VIPR2 VIPR2 GLP2R GLP2R GCGR GCGR WNT11 WNT11 ADGRE2 ADGRE2 UCN UCN WNT10B WNT10B PTHLH PTHLH CRHR1 CRHR1 VIPR1 VIPR1 GNG3 GNG3 GNG11 GNG11 PTCH1 PTCH1 CD55 CD55 GNGT1 GNGT1 FZD5 FZD5 ADGRE5 ADGRE5 WNT9A WNT9A ADM2 ADM2 UCN2 UCN2 GIP GIP WNT7B WNT7B CALCRL CALCRL WNT5A WNT5A SCT SCT DHH DHH GCG GCG GNB2 GNB2 GNB5 GNB5 WNT1 WNT1 PTH2 PTH2 CALCR CALCR SMO SMO CRHR2 CRHR2 SCTR SCTR FZD2 FZD2 LOC694289 LOC694289 WNT2B WNT2B GIPR GIPR FZD10 FZD10 WNT8B WNT8B ADCYAP1R1 ADCYAP1R1 PTH2R PTH2R GNB3 GNB3 WNT3A WNT3A GNB4 GNB4 FZD4 FZD4 FAP FAP ADGRL3 ADGRL3 ADGRL2 ADGRL2 WNT16 WNT16 RAMP2 RAMP2 FZD8 FZD8 GNG13 GNG13 IHH IHH CALCB CALCB UCN3 UCN3 WNT9B WNT9B RAMP1 RAMP1 RAMP3 RAMP3 WNT10A WNT10A ADCYAP1 ADCYAP1 GNG7 GNG7 WNT4 WNT4 GNB1 GNB1 ADM ADM WNT3 WNT3 ADGRE1 ADGRE1 FZD7 FZD7 IAPP IAPP PTH1R PTH1R GHRH GHRH FZD6 FZD6 GLP1R GLP1R WNT8A WNT8A GNG5 GNG5 CRH CRH CRHBP CRHBP VIP VIP WNT7A WNT7A WNT2 WNT2 ADGRL1 ADGRL1 CALCA CALCA GNG4 GNG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (565 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (438 aa)
GLP2RGlucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
ADGRE2Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. (925 aa)
UCNUrocortin. (124 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PTHLHParathyroid hormone-related protein isoform 1 preproprotein. (177 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] (444 aa)
VIPR1Vasoactive intestinal polypeptide receptor 1; Belongs to the G-protein coupled receptor 2 family. (457 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PTCH1Patched 1. (1452 aa)
CD55Uncharacterized protein. (566 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ADGRE5Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (1130 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
ADM2Uncharacterized protein. (148 aa)
UCN2Urocortin 2. (114 aa)
GIPGastric inhibitory polypeptide. (153 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
SCTSecretin. (125 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
GCGGlucagon. (263 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNB5G protein subunit beta 5. (395 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PTH2Uncharacterized protein. (98 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
LOC694289Uncharacterized protein. (394 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (538 aa)
PTH2RParathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (550 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ADGRL3Latrophilin-3; Belongs to the G-protein coupled receptor 2 family. (1469 aa)
ADGRL2Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. (1479 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RAMP2Receptor activity-modifying protein 2. (175 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
CALCBCalcitonin related polypeptide beta. (143 aa)
UCN3Urocortin 3. (210 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
RAMP1Uncharacterized protein. (204 aa)
RAMP3Uncharacterized protein. (172 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (198 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
ADMAdrenomedullin. (211 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ADGRE1Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (796 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
IAPPIslet amyloid polypeptide. (89 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CRHCorticotropin releasing hormone. (196 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
VIPVIP peptides isoform 1 preproprotein. (170 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1511 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.