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PDE5A PDE5A LRP8 LRP8 APOB APOB PPP2R5E PPP2R5E P2RX1 P2RX1 ATP2A3 ATP2A3 MAPK14 MAPK14 PTPN6 PTPN6 LOC694289 LOC694289 PRKG1 PRKG1 ATP2B3 ATP2B3 NOS1 NOS1 KCNMB2 KCNMB2 P2RX2 P2RX2 SLC8A1 SLC8A1 MRVI1 MRVI1 GNB5 GNB5 KCNMA1 KCNMA1 PRKG2 PRKG2 ATP2B2 ATP2B2 NOS3 NOS3 P2RX6 P2RX6 PPP2CB PPP2CB PLA2G4A PLA2G4A P2RX4 P2RX4 PTGIR PTGIR PPP2R5D PPP2R5D GNB1 GNB1 FGR FGR F6ZWK6_MACMU F6ZWK6_MACMU GNG13 GNG13 PDE1A PDE1A STIM1 STIM1 TRPC7 TRPC7 SH2B1 SH2B1 PPP2R1A PPP2R1A GNG5 GNG5 SRI SRI ATP2B1 ATP2B1 P2RX5 P2RX5 TRPC3 TRPC3 P2RX7 P2RX7 ITPR2 ITPR2 ITPR3 ITPR3 ATP2A2 ATP2A2 PDE1B PDE1B ITPR1 ITPR1 GNGT1 GNGT1 REEP3 REEP3 TRPC6 TRPC6 ORAI1 ORAI1 PPP2R1B PPP2R1B PDE9A PDE9A PTPN11 PTPN11 GNG11 GNG11 GNG3 GNG3 GUCY1B1 GUCY1B1 SLC8A2 SLC8A2 PPP2R5B PPP2R5B PPP2R5C PPP2R5C PECAM1 PECAM1 GNB2 GNB2 PPP2R5A PPP2R5A GUCY1A2 GUCY1A2 ORAI2 ORAI2 KCNMB1 KCNMB1 GUCY1A1 GUCY1A1 PAFAH2 PAFAH2 REEP4 REEP4 REEP2 REEP2 ATP2B4 ATP2B4 NOS2 NOS2 P2RX3 P2RX3 PDE10A PDE10A GNG4 GNG4 GNB4 GNB4 SLC8A3 SLC8A3 ORAI3 ORAI3 GNG7 GNG7 KCNMB3 KCNMB3 PDE11A PDE11A GNB3 GNB3 F6PNW7_MACMU F6PNW7_MACMU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE5APhosphodiesterase. (875 aa)
LRP8LDL receptor related protein 8. (959 aa)
APOBApolipoprotein B. (4555 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (471 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1092 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
LOC694289Uncharacterized protein. (394 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (268 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (496 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
MRVI1Murine retrovirus integration site 1 homolog. (886 aa)
GNB5G protein subunit beta 5. (395 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1233 aa)
PRKG2cGMP-dependent protein kinase. (781 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PLA2G4APhospholipase A2. (749 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (467 aa)
PTGIRProstaglandin I2 receptor. (386 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
FGRTyrosine-protein kinase. (529 aa)
F6ZWK6_MACMUUncharacterized protein. (3263 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PDE1APhosphodiesterase. (570 aa)
STIM1Stromal interaction molecule 1. (684 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
SH2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1087 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SRISorcin isoform a. (198 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (573 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
PDE1BPhosphodiesterase. (538 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
REEP3Receptor expression-enhancing protein. (369 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (301 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
PDE9APhosphodiesterase. (633 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (505 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (834 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (733 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (261 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-3 isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PAFAH2Platelet-activating factor acetylhydrolase. (408 aa)
REEP4Receptor expression-enhancing protein. (257 aa)
REEP2Receptor expression-enhancing protein. (285 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1299 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
PDE10APhosphodiesterase. (1059 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
ORAI3Protein orai-3. (295 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (283 aa)
PDE11APhosphodiesterase. (933 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
F6PNW7_MACMUUncharacterized protein. (287 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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