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THAP6 THAP6 CNBD2 CNBD2 GPR15 GPR15 LOC694289 LOC694289 LHCGR LHCGR SCTR SCTR PDE7A PDE7A CRHR2 CRHR2 PDE4D PDE4D GPR25 GPR25 ARR3 ARR3 CALCR CALCR PTH2 PTH2 TAAR1 TAAR1 PRKAR2B PRKAR2B GPR85 GPR85 GPR39 GPR39 PTGER4 PTGER4 GPR84 GPR84 HTR4 HTR4 FSHR FSHR MC4R MC4R GNB5 GNB5 ITGB1 ITGB1 VIP VIP TSHR TSHR PDE8A PDE8A GNAI2 GNAI2 SRC SRC PRKACG PRKACG THAP7 THAP7 ADCY4 ADCY4 CRH CRH GNG5 GNG5 GLP1R GLP1R GNAI1 GNAI1 PDE4A PDE4A ADRB3 ADRB3 MC1R MC1R PDE7B PDE7B NPSR1 NPSR1 GPR45 GPR45 GHRH GHRH PTH1R PTH1R IAPP IAPP GLP2R GLP2R ADCY8 ADCY8 VIPR2 VIPR2 GHRHR GHRHR PDE1B PDE1B INSL3 INSL3 HRH2 HRH2 ADRB1 ADRB1 GNGT1 GNGT1 ADCY3 ADCY3 GPER1 GPER1 GNG11 GNG11 GNG3 GNG3 AGGF1 AGGF1 ADCY5 ADCY5 GRK2 GRK2 GCGR GCGR RLN2 RLN2 PRKACA PRKACA VIPR1 VIPR1 CRHR1 CRHR1 TAAR2 TAAR2 FSHB FSHB PTGIR PTGIR PTHLH PTHLH TAAR3 TAAR3 ADCY2 ADCY2 PRKACB PRKACB GPR27 GPR27 GPR32 GPR32 HTR7 HTR7 ADORA2B ADORA2B CALCA CALCA PDE10A PDE10A HTR6 HTR6 AVPR2 AVPR2 GNG4 GNG4 GRK3 GRK3 ADCY6 ADCY6 PTH PTH FN1 FN1 LOC114675571 LOC114675571 ADM ADM GPR173 GPR173 GNB1 GNB1 CYSLTR2 CYSLTR2 ARRB2 ARRB2 RLN3 RLN3 NPS NPS GPBAR1 GPBAR1 GPR63 GPR63 RXFP2 RXFP2 GNG7 GNG7 LOC114675602 LOC114675602 ADCY9 ADCY9 ADCYAP1 ADCYAP1 RAMP3 RAMP3 GPHB5 GPHB5 ADCY1 ADCY1 PDE11A PDE11A GPR20 GPR20 RAMP1 RAMP1 CALCB CALCB TSHB TSHB GNB2 GNB2 GCG GCG AVP AVP MC3R MC3R GRK5 GRK5 CGA CGA GPHA2 GPHA2 GRK6 GRK6 SCT SCT ADCY7 ADCY7 CALCRL CALCRL PRKAR1B PRKAR1B POMC POMC GIP GIP MC5R MC5R ADM2 ADM2 ARRB1 ARRB1 PRKAR1A PRKAR1A GNAT3 GNAT3 PTGER2 PTGER2 PTGDR PTGDR PRKAR2A PRKAR2A PDE3B PDE3B GNG13 GNG13 PDE1A PDE1A GPR150 GPR150 GNAZ GNAZ RAMP2 RAMP2 ADRB2 ADRB2 DRD5 DRD5 FAP FAP ITGA5 ITGA5 GNB4 GNB4 RXFP1 RXFP1 TAAR5 TAAR5 PDE4C PDE4C DRD1 DRD1 GNB3 GNB3 PTH2R PTH2R ADCYAP1R1 ADCYAP1R1 GNAI3 GNAI3 GPR176 GPR176 SHC1 SHC1 GIPR GIPR PDE3A PDE3A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THAP6THAP domain containing 6. (282 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (532 aa)
GPR15G-protein coupled receptor 15; Probable chemokine receptor. SIV-1 coreceptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LOC694289Uncharacterized protein. (394 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (704 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
PDE7APhosphodiesterase. (527 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
PDE4DPhosphodiesterase. (809 aa)
GPR25G protein-coupled receptor 25; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ARR3Arrestin 3. (388 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
PTH2Uncharacterized protein. (98 aa)
TAAR1Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained spe [...] (339 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
GPR85Probable G-protein coupled receptor 85. (370 aa)
GPR39G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (454 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (490 aa)
GPR84Inflammation-related G-protein coupled receptor EX33. (396 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (428 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
MC4RMelanocortin 4 receptor. (332 aa)
GNB5G protein subunit beta 5. (395 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
VIPVIP peptides isoform 1 preproprotein. (170 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
PDE8APhosphodiesterase. (829 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
SRCTyrosine-protein kinase. (644 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
THAP7THAP domain-containing protein 7 isoform 2. (309 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
CRHCorticotropin releasing hormone. (196 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PDE4APhosphodiesterase. (886 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (418 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). (317 aa)
PDE7BPhosphodiesterase. (505 aa)
NPSR1Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. (371 aa)
GPR45G protein-coupled receptor 45. (433 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
IAPPIslet amyloid polypeptide. (89 aa)
GLP2RGlucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (438 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (565 aa)
PDE1BPhosphodiesterase. (538 aa)
INSL3IlGF domain-containing protein. (131 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
AGGF1Phosphodiesterase. (1119 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
RLN2Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. (185 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
VIPR1Vasoactive intestinal polypeptide receptor 1; Belongs to the G-protein coupled receptor 2 family. (457 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] (444 aa)
TAAR2Trace amine associated receptor 2 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (337 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
PTGIRProstaglandin I2 receptor. (386 aa)
PTHLHParathyroid hormone-related protein isoform 1 preproprotein. (177 aa)
TAAR3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
GPR27G protein-coupled receptor 27. (376 aa)
GPR32G protein-coupled receptor 32; Belongs to the G-protein coupled receptor 1 family. (371 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (445 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
PDE10APhosphodiesterase. (1059 aa)
HTR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (711 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
LOC114675571G_PROTEIN_RECEP_F1_2 domain-containing protein. (325 aa)
ADMAdrenomedullin. (211 aa)
GPR173Putative G-protein coupled receptor 173. (373 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
ARRB2Arrestin beta 2. (575 aa)
RLN3Relaxin 3. (166 aa)
NPSNeuropeptide S. (89 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
GPR63Putative G-protein coupled receptor 63. (419 aa)
RXFP2G_PROTEIN_RECEP_F1_2 domain-containing protein. (753 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC114675602IlGF domain-containing protein. (132 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (198 aa)
RAMP3Uncharacterized protein. (172 aa)
GPHB5Glycoprotein-beta 5. (130 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PDE11APhosphodiesterase. (933 aa)
GPR20G-protein coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RAMP1Uncharacterized protein. (204 aa)
CALCBCalcitonin related polypeptide beta. (143 aa)
TSHBThyroid stimulating hormone subunit beta. (158 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GCGGlucagon. (263 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
MC3RMelanocortin 3 receptor. (323 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (161 aa)
GPHA2Uncharacterized protein. (182 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (560 aa)
SCTSecretin. (125 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
PRKAR1BCyclic nucleotide-binding domain-containing protein. (494 aa)
POMCUncharacterized protein. (392 aa)
GIPGastric inhibitory polypeptide. (153 aa)
MC5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (325 aa)
ADM2Uncharacterized protein. (148 aa)
ARRB1Arrestin beta 1. (529 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
PTGER2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
PTGDRProstaglandin D2 receptor. (359 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
PDE3BPhosphodiesterase. (1117 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PDE1APhosphodiesterase. (570 aa)
GPR150G protein-coupled receptor 150. (435 aa)
GNAZGuanine nucleotide-binding protein G(Z) subunit alpha. (355 aa)
RAMP2Receptor activity-modifying protein 2. (175 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
RXFP1Relaxin family peptide receptor 1. (783 aa)
TAAR5Trace amine associated receptor 5; Belongs to the G-protein coupled receptor 1 family. (337 aa)
PDE4CPhosphodiesterase. (712 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PTH2RParathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (550 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (538 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GPR176Putative G-protein coupled receptor 176. (515 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
PDE3APhosphodiesterase. (1141 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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