STRINGSTRING
ADRA2C ADRA2C PRKAR2A PRKAR2A GNG13 GNG13 GNA11 GNA11 FAP FAP CACNA1A CACNA1A GNB4 GNB4 ACSL4 ACSL4 PLCB1 PLCB1 GNB3 GNB3 KCNB1 KCNB1 CACNA2D2 CACNA2D2 CACNB2 CACNB2 CACNA1F CACNA1F THAP6 THAP6 LOC694289 LOC694289 IQGAP1 IQGAP1 PLCB3 PLCB3 CACNA1C CACNA1C CACNA1E CACNA1E PRKAR2B PRKAR2B STXBP1 STXBP1 GNA14 GNA14 KCNS3 KCNS3 GNB5 GNB5 GNAI2 GNAI2 PRKACG PRKACG THAP7 THAP7 GNG5 GNG5 AHCYL1 AHCYL1 GLP1R GLP1R ABCC8 ABCC8 RAPGEF5 RAPGEF5 INS INS SLC2A2 SLC2A2 KCNC2 KCNC2 ITPR2 ITPR2 KCNG2 KCNG2 MARCKS MARCKS ITPR3 ITPR3 ADRA2A ADRA2A ADCY8 ADCY8 CACNB3 CACNB3 STX1A STX1A ITPR1 ITPR1 GNGT1 GNGT1 SYT5 SYT5 CACNA1D CACNA1D GNG11 GNG11 GNG3 GNG3 CACNA2D1 CACNA2D1 AKAP5 AKAP5 ADCY5 ADCY5 RAPGEFL1 RAPGEFL1 RAPGEF4 RAPGEF4 PRKACA PRKACA SLC2A1 SLC2A1 RAPGEF3 RAPGEF3 PRKACB PRKACB GNAQ GNAQ SNAP25 SNAP25 GNA15 GNA15 GNG4 GNG4 ADCY6 ADCY6 GNB1 GNB1 GNG7 GNG7 PLCB2 PLCB2 PRKCA PRKCA RAP1A RAP1A GNB2 GNB2 GCG GCG CD36 CD36 PRKAR1B PRKAR1B ACSL3 ACSL3 PRKAR1A PRKAR1A FFAR1 FFAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRA2CAdrenoceptor alpha 2C. (458 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
ACSL4Long-chain-fatty-acid--CoA ligase 4 isoform 2. (711 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1153 aa)
CACNB2SH3 domain-containing protein. (660 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1970 aa)
THAP6THAP domain containing 6. (282 aa)
LOC694289Uncharacterized protein. (394 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1667 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2412 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
STXBP1Syntaxin-binding protein 1 isoform a; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
GNA14G protein subunit alpha 14. (355 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
GNB5G protein subunit beta 5. (395 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
THAP7THAP domain-containing protein 7 isoform 2. (309 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AHCYL1Putative adenosylhomocysteinase 2 isoform a; Belongs to the adenosylhomocysteinase family. (530 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (883 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2 isoform KV3.2b; Belongs to the potassium channel family. (638 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (467 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (331 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CACNB3SH3 domain-containing protein. (498 aa)
STX1ASyntaxin-1A isoform 1; Belongs to the syntaxin family. (288 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SYT5Synaptotagmin 5. (386 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (667 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1047 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
GNA15Uncharacterized protein. (414 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GCGGlucagon. (263 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PRKAR1BCyclic nucleotide-binding domain-containing protein. (494 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
FFAR1Uncharacterized protein. (300 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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