(62 nodes) Recycling pathway of L1 network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACTL9	Uncharacterized protein; Belongs to the actin family. (416 aa)
	RDX	Radixin. (604 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1206 aa)
	AP2B1	AP complex subunit beta. (949 aa)
	LOC707215	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	SHTN1	Shootin 1. (676 aa)
	TUBB6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (772 aa)
	LOC705671	Uncharacterized protein. (398 aa)
	HMCN1	Hemicentin 1. (5635 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	ACTL8	Actin like 8; Belongs to the actin family. (366 aa)
	TUBB	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (507 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (586 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1002 aa)
	TUBB1	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	ACTRT2	Actin related protein T2; Belongs to the actin family. (377 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	DNM1	Dynamin-1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
	DNM2	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
	ACTL7B	Actin-like-7-beta; Belongs to the actin family. (415 aa)
	ACTL7A	Actin like 7A; Belongs to the actin family. (435 aa)
	EZR	Ezrin. (598 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	TUBA3D	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	VSIG10L	V-set and immunoglobulin domain containing 10 like. (999 aa)
	F6QAX2_MACMU	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A isoform 1. (1198 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
	TUBA1A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
	DPYSL2	Dihydropyrimidinase like 2. (681 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (802 aa)
	NUMB	NUMB endocytic adaptor protein. (711 aa)
	ACTG1	Actin, cytoplasmic 2. (375 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
	AP2S1	Clat_adaptor_s domain-containing protein. (240 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (860 aa)
	ACTRT1	Actin-related protein T1; Belongs to the actin family. (375 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (755 aa)
	ACTB	Uncharacterized protein. (421 aa)
	ENSMMUP00000053367	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (333 aa)
	TUBA1C	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
	KIF4A	Chromosome-associated kinesin KIF4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1234 aa)
	HMCN2	Hemicentin 2. (5002 aa)
	VSIG10L2	V-set and immunoglobulin domain containing 10 like 2. (767 aa)
	ENSMMUP00000066739	Uncharacterized protein. (195 aa)
	ENSMMUP00000068149	Uncharacterized protein. (237 aa)
	TUBAL3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	MSN	FERM domain-containing protein. (592 aa)
	L1CAM	Uncharacterized protein. (1420 aa)
	TUBB2B	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (383 aa)
	KIF4B	Kinesin family member 4B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1177 aa)
	TUBB4A	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	LOC704609	Uncharacterized protein; Belongs to the actin family. (912 aa)
	ENSMMUP00000080921	Uncharacterized protein. (232 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	LOC705671	ENSMMUP00000053310	ENSMMUP00000012328	Uncharacterized protein.	Uncharacterized protein.	0.551
ACTB	LOC707215	ENSMMUP00000053310	ENSMMUP00000008770	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.531
ACTB	TUBA1A	ENSMMUP00000053310	ENSMMUP00000037576	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.594
ACTB	TUBA1C	ENSMMUP00000053310	ENSMMUP00000054285	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.619
ACTB	TUBA3D	ENSMMUP00000053310	ENSMMUP00000027858	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.451
ACTB	TUBA4A	ENSMMUP00000053310	ENSMMUP00000025785	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.538
ACTB	TUBA8	ENSMMUP00000053310	ENSMMUP00000037323	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.538
ACTB	TUBAL3	ENSMMUP00000053310	ENSMMUP00000069263	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.557
ACTB	TUBB	ENSMMUP00000053310	ENSMMUP00000014438	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.429
ACTB	TUBB4A	ENSMMUP00000053310	ENSMMUP00000076820	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.407
ACTG1	EZR	ENSMMUP00000044023	ENSMMUP00000025573	Actin, cytoplasmic 2.	Ezrin.	0.934
ACTG1	LOC705671	ENSMMUP00000044023	ENSMMUP00000012328	Actin, cytoplasmic 2.	Uncharacterized protein.	0.900
ACTG1	LOC707215	ENSMMUP00000044023	ENSMMUP00000008770	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.449
ACTG1	MSN	ENSMMUP00000044023	ENSMMUP00000070350	Actin, cytoplasmic 2.	FERM domain-containing protein.	0.920
ACTG1	RDX	ENSMMUP00000044023	ENSMMUP00000002993	Actin, cytoplasmic 2.	Radixin.	0.912
ACTG1	TUBA1A	ENSMMUP00000044023	ENSMMUP00000037576	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.642
ACTG1	TUBA1C	ENSMMUP00000044023	ENSMMUP00000054285	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.657
ACTG1	TUBA3D	ENSMMUP00000044023	ENSMMUP00000027858	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.502
ACTG1	TUBA4A	ENSMMUP00000044023	ENSMMUP00000025785	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.469
ACTG1	TUBA8	ENSMMUP00000044023	ENSMMUP00000037323	Actin, cytoplasmic 2.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.456