18 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ENSMMUP00000069269	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
	POLD1	DNA polymerase. (1145 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (931 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	EXO1	Exonuclease 1. (846 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (938 aa)
	MEIOB	Meiosis specific with OB-fold. (550 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	POLD3	DNA polymerase delta subunit 3. (466 aa)
	F7DM39_MACMU	Uncharacterized protein. (143 aa)
	MLH1	MutL homolog 1. (756 aa)
	POLD4	DNA polymerase delta subunit p12. (107 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (536 aa)
	LIG1	DNA ligase. (1108 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMUP00000069269	EXO1	ENSMMUP00000069269	ENSMMUP00000037489	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Exonuclease 1.	0.784
ENSMMUP00000069269	F7DM39_MACMU	ENSMMUP00000069269	ENSMMUP00000028100	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.880
ENSMMUP00000069269	LIG1	ENSMMUP00000069269	ENSMMUP00000069832	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA ligase.	0.649
ENSMMUP00000069269	MLH1	ENSMMUP00000069269	ENSMMUP00000029670	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	MutL homolog 1.	0.589
ENSMMUP00000069269	MSH2	ENSMMUP00000069269	ENSMMUP00000036559	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.762
ENSMMUP00000069269	MSH3	ENSMMUP00000069269	ENSMMUP00000045732	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.594
ENSMMUP00000069269	MSH6	ENSMMUP00000069269	ENSMMUP00000030085	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.848
ENSMMUP00000069269	PCNA	ENSMMUP00000069269	ENSMMUP00000062455	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.874
ENSMMUP00000069269	PMS2	ENSMMUP00000069269	ENSMMUP00000035494	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	PMS1 homolog 2, mismatch repair system component.	0.506
ENSMMUP00000069269	POLD1	ENSMMUP00000069269	ENSMMUP00000068636	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase.	0.788
ENSMMUP00000069269	POLD2	ENSMMUP00000069269	ENSMMUP00000079598	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase delta 2, accessory subunit.	0.575
ENSMMUP00000069269	POLD3	ENSMMUP00000069269	ENSMMUP00000027170	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase delta subunit 3.	0.419
ENSMMUP00000069269	RPA3	ENSMMUP00000069269	ENSMMUP00000001149	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication protein A 14 kDa subunit.	0.880
EXO1	ENSMMUP00000069269	ENSMMUP00000037489	ENSMMUP00000069269	Exonuclease 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.784
EXO1	F7DM39_MACMU	ENSMMUP00000037489	ENSMMUP00000028100	Exonuclease 1.	Uncharacterized protein.	0.607
EXO1	LIG1	ENSMMUP00000037489	ENSMMUP00000069832	Exonuclease 1.	DNA ligase.	0.927
EXO1	MEIOB	ENSMMUP00000037489	ENSMMUP00000000992	Exonuclease 1.	Meiosis specific with OB-fold.	0.716
EXO1	MLH1	ENSMMUP00000037489	ENSMMUP00000029670	Exonuclease 1.	MutL homolog 1.	0.986
EXO1	MSH2	ENSMMUP00000037489	ENSMMUP00000036559	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.983
EXO1	MSH3	ENSMMUP00000037489	ENSMMUP00000045732	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.923