STRINGSTRING
PSMB1 PSMB1 PSMD2 PSMD2 KRAS KRAS PSMD12 PSMD12 CLEC7A CLEC7A PSMD5 PSMD5 NFKB2 NFKB2 CARD9 CARD9 PSMC2 PSMC2 FCER1G FCER1G PSMF1 PSMF1 PLCG2 PLCG2 BCL10 BCL10 PSMB5 PSMB5 PSMB11 PSMB11 MAP3K14 MAP3K14 PSMD4 PSMD4 PSME4 PSME4 MAP3K20 MAP3K20 MUC5B MUC5B PSMA4 PSMA4 PSMB9 PSMB9 F7B371_MACMU F7B371_MACMU PDPK1 PDPK1 PSMD13 PSMD13 PSMD1 PSMD1 PAK2 PAK2 TAB1 TAB1 PSME1 PSME1 PSMB6 PSMB6 PSMB2 PSMB2 CLEC6A CLEC6A CLEC4D CLEC4D CLEC4E CLEC4E RPS27A RPS27A RELB RELB MUC13 MUC13 MALT1 MALT1 ICAM2 ICAM2 TAB2 TAB2 RPS27A-2 RPS27A-2 PSMC3 PSMC3 PPP3CB PPP3CB UBA52 UBA52 PSMD9 PSMD9 ERAS ERAS PSMC4 PSMC4 WDR92 WDR92 NFAT5 NFAT5 TRAF6 TRAF6 PSMA7 PSMA7 PAK1 PAK1 MUC7 MUC7 CISD1 CISD1 SRC SRC PRKACG PRKACG PSMD3 PSMD3 PSMB4 PSMB4 CLEC10A CLEC10A HRAS HRAS NFATC3 NFATC3 CD209 CD209 AHCYL1 AHCYL1 CDC34 CDC34 IKBKB IKBKB PSMC1 PSMC1 F7ALC4_MACMU F7ALC4_MACMU MAP3K7 MAP3K7 NFKB1 NFKB1 F7HHF9_MACMU F7HHF9_MACMU CASP8 CASP8 MAP4 MAP4 PSMD6 PSMD6 ITPR2 ITPR2 IKBKG IKBKG PSMD10 PSMD10 RPS6KA5 RPS6KA5 PSMA8 PSMA8 KXD1 KXD1 ITPR3 ITPR3 CHUK CHUK ENSMMUP00000044860 ENSMMUP00000044860 UBC UBC ITPR1 ITPR1 PSMB3 PSMB3 PSMA6 PSMA6 NFATC2 NFATC2 FBXW11 FBXW11 MUC1 MUC1 BTRC BTRC NRAS NRAS UBB UBB CCDC71L CCDC71L PSME2 PSME2 UBE2N UBE2N LYN LYN PSMD14 PSMD14 PSME3 PSME3 PSMA2 PSMA2 NFKBIA NFKBIA PRKACA PRKACA SKP1-2 SKP1-2 RELA RELA PSMD8 PSMD8 RAF1 RAF1 TAB3 TAB3 CLEC4C CLEC4C PRKACB PRKACB PSMA3 PSMA3 PPP3CA PPP3CA PPP3R1 PPP3R1 CARD11 CARD11 PSMC5 PSMC5 PSMC6 PSMC6 SYK SYK MUC3A MUC3A PSMD7 PSMD7 CREBBP CREBBP CUL1 CUL1 MUC20 MUC20 ENSMMUP00000067421 ENSMMUP00000067421 PSMB10 PSMB10 MUC12 MUC12 ENSMMUP00000069031 ENSMMUP00000069031 ENSMMUP00000070235 ENSMMUP00000070235 CLEC4A CLEC4A UBA3 UBA3 PSMA1 PSMA1 ENSMMUP00000071311 ENSMMUP00000071311 PSMB7 PSMB7 LOC699631 LOC699631 PYCARD PYCARD PSMD11 PSMD11 MUCL1 MUCL1 PRKCD PRKCD EP300 EP300 PAK3 PAK3 PSMA5 PSMA5 IL1B IL1B UBE2M UBE2M FYN FYN MUC6 MUC6 NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB1Proteasome subunit beta. (241 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (476 aa)
CLEC7AC-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2- mediated inflammatory response and for TLR2-mediated activation of NF- kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does [...] (281 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
NFKB2Nuclear factor kappa B subunit 2. (907 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
PSMC226S protease regulatory subunit 7 isoform 1; Belongs to the AAA ATPase family. (433 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
PSMF1Proteasome inhibitor subunit 1. (288 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMB11Proteasome subunit beta. (243 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PSMD4VWFA domain-containing protein. (400 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (4928 aa)
PSMA4Proteasome subunit alpha type. (300 aa)
PSMB9Proteasome subunit beta. (219 aa)
F7B371_MACMUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (378 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa)
PSME1Proteasome activator complex subunit 1 isoform 1. (249 aa)
PSMB6Proteasome subunit beta. (285 aa)
PSMB2Proteasome subunit beta. (201 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
CLEC4EC-type lectin domain family 4 member E. (274 aa)
RPS27AUncharacterized protein. (156 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
MUC13Mucin 13, cell surface associated. (495 aa)
MALT1MALT1 paracaspase. (824 aa)
ICAM2ICAM_N domain-containing protein. (275 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
RPS27A-2Ubiquitin-40S ribosomal protein S27a. (156 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (439 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9. (223 aa)
ERASGTPase ERas. (233 aa)
PSMC426S protease regulatory subunit 6B isoform 1; Belongs to the AAA ATPase family. (418 aa)
WDR92WD repeat-containing protein 92. (357 aa)
NFAT5Nuclear factor of activated T cells 5. (1578 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PAK1Non-specific serine/threonine protein kinase. (575 aa)
MUC7Mucin 7, secreted. (446 aa)
CISD1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
SRCTyrosine-protein kinase. (644 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
CLEC10AC-type lectin domain containing 10A. (287 aa)
HRASTransforming protein p21. (189 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa)
AHCYL1Putative adenosylhomocysteinase 2 isoform a; Belongs to the adenosylhomocysteinase family. (530 aa)
CDC34Ubiquitin-conjugating enzyme E2 R1; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
F7ALC4_MACMUAAA domain-containing protein; Belongs to the AAA ATPase family. (360 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
NFKB1Uncharacterized protein. (977 aa)
F7HHF9_MACMUAAA domain-containing protein; Belongs to the AAA ATPase family. (352 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
MAP4Microtubule-associated protein. (2279 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (253 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
KXD1KxDL domain-containing protein. (231 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSMMUP00000044860Uncharacterized protein. (5190 aa)
UBCUncharacterized protein. (270 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
PSMB3Proteasome subunit beta. (261 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
FBXW11Uncharacterized protein. (563 aa)
MUC1Mucin 1, cell surface associated. (483 aa)
BTRCUncharacterized protein. (629 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
UBBUncharacterized protein. (229 aa)
CCDC71LCoiled-coil domain containing 71 like. (235 aa)
PSME2Proteasome activator subunit 2. (248 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
LYNTyrosine-protein kinase. (577 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SKP1-2Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
PSMD8CSN8_PSD8_EIF3K domain-containing protein. (364 aa)
RAF1Uncharacterized protein. (668 aa)
TAB3Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa)
CLEC4CC-type lectin domain family 4 member C. (212 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PSMA3Proteasome subunit alpha type. (267 aa)
PPP3CASerine/threonine-protein phosphatase. (547 aa)
PPP3R1Uncharacterized protein. (171 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
PSMC526S protease regulatory subunit 8 isoform 1; Belongs to the AAA ATPase family. (406 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (410 aa)
SYKTyrosine-protein kinase. (635 aa)
MUC3AMucin 3A, cell surface associated. (4055 aa)
PSMD7MPN domain-containing protein. (323 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
CUL1Cullin 1; Belongs to the cullin family. (809 aa)
MUC20Mucin 20, cell surface associated. (536 aa)
ENSMMUP00000067421Ubiquitin-like domain-containing protein. (135 aa)
PSMB10Proteasome subunit beta. (312 aa)
MUC12Uncharacterized protein. (3992 aa)
ENSMMUP00000069031Uncharacterized protein. (158 aa)
ENSMMUP00000070235Ubiquitin-like domain-containing protein. (110 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
UBA3NEDD8-activating enzyme E1 catalytic subunit isoform 1. (463 aa)
PSMA1Proteasome endopeptidase complex. (301 aa)
ENSMMUP00000071311UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (225 aa)
PSMB7Proteasome subunit beta. (277 aa)
LOC699631Proteasome subunit alpha type. (206 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (195 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (454 aa)
MUCL1Uncharacterized protein. (98 aa)
PRKCDProtein kinase C. (729 aa)
EP300Histone acetyltransferase p300. (2414 aa)
PAK3Uncharacterized protein. (580 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
FYNTyrosine-protein kinase. (589 aa)
MUC6Uncharacterized protein. (4978 aa)
NFATC1Nuclear factor of activated T cells 1. (943 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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