(26 nodes) Translesion synthesis by POLK network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3145 aa)
	RPS27A-2	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	MEIOB	Meiosis specific with OB-fold. (550 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	RFC3	Replication factor C subunit 3 isoform 1. (356 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	RFC2	Replication factor C subunit 2. (233 aa)
	RFC5	Replication factor C subunit 5 isoform 1. (340 aa)
	RPS27A	Uncharacterized protein. (156 aa)
	ENSMMUP00000070235	Ubiquitin-like domain-containing protein. (110 aa)
	ENSMMUP00000069269	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
	ENSMMUP00000067421	Ubiquitin-like domain-containing protein. (135 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1285 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC1	Replication factor C subunit 1. (1146 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (556 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (531 aa)
	UBB	Uncharacterized protein. (229 aa)
	ATAD5	ATPase family AAA domain containing 5. (1848 aa)
	UBC	Uncharacterized protein. (270 aa)
	KXD1	KxDL domain-containing protein. (231 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (212 aa)
	POLK	DNA polymerase kappa. (868 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	F7DM39_MACMU	Uncharacterized protein. (143 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSMMUP00000069269	ENSMMUP00000050281	ENSMMUP00000069269	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.677
ATAD5	F7DM39_MACMU	ENSMMUP00000050281	ENSMMUP00000028100	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.463
ATAD5	MAD2L2	ENSMMUP00000050281	ENSMMUP00000040604	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.612
ATAD5	MEIOB	ENSMMUP00000050281	ENSMMUP00000000992	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.677
ATAD5	PCNA	ENSMMUP00000050281	ENSMMUP00000062455	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.964
ATAD5	POLK	ENSMMUP00000050281	ENSMMUP00000034468	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.625
ATAD5	REV1	ENSMMUP00000050281	ENSMMUP00000066793	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.661
ATAD5	REV3L	ENSMMUP00000050281	ENSMMUP00000028357	ATPase family AAA domain containing 5.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.752
ATAD5	RFC1	ENSMMUP00000050281	ENSMMUP00000057228	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.777
ATAD5	RFC2	ENSMMUP00000050281	ENSMMUP00000005125	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.984
ATAD5	RFC3	ENSMMUP00000050281	ENSMMUP00000004492	ATPase family AAA domain containing 5.	Replication factor C subunit 3 isoform 1.	0.978
ATAD5	RFC4	ENSMMUP00000050281	ENSMMUP00000004943	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.985
ATAD5	RFC5	ENSMMUP00000050281	ENSMMUP00000013401	ATPase family AAA domain containing 5.	Replication factor C subunit 5 isoform 1.	0.971
ATAD5	RPA1	ENSMMUP00000050281	ENSMMUP00000042285	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.677
ATAD5	RPA3	ENSMMUP00000050281	ENSMMUP00000001149	ATPase family AAA domain containing 5.	Replication protein A 14 kDa subunit.	0.463
ENSMMUP00000067421	F7DM39_MACMU	ENSMMUP00000067421	ENSMMUP00000028100	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.409
ENSMMUP00000067421	KXD1	ENSMMUP00000067421	ENSMMUP00000043399	Ubiquitin-like domain-containing protein.	KxDL domain-containing protein.	0.513
ENSMMUP00000067421	MAD2L2	ENSMMUP00000067421	ENSMMUP00000040604	Ubiquitin-like domain-containing protein.	Mitotic arrest deficient 2 like 2.	0.434
ENSMMUP00000067421	PCNA	ENSMMUP00000067421	ENSMMUP00000062455	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.766
ENSMMUP00000067421	POLK	ENSMMUP00000067421	ENSMMUP00000034468	Ubiquitin-like domain-containing protein.	DNA polymerase kappa.	0.527