STRINGSTRING
RPS27A-2 RPS27A-2 POLN POLN RPA3 RPA3 MEIOB MEIOB FANCE FANCE UBA52 UBA52 FANCM FANCM DCLRE1A DCLRE1A EME1 EME1 FANCB FANCB FAAP24 FAAP24 MUS81 MUS81 DCLRE1B DCLRE1B FANCF FANCF F7DM39_MACMU F7DM39_MACMU RPA1 RPA1 PROSER1 PROSER1 SLX4 SLX4 ATR ATR ATRIP ATRIP FANCI FANCI UBE2T UBE2T RPS27A RPS27A ERCC4 ERCC4 SLX1A SLX1A KXD1 KXD1 WDR48 WDR48 FANCA FANCA UBC UBC UBB UBB ERCC1 ERCC1 FANCL FANCL FANCD2 FANCD2 CENPX CENPX EME2 EME2 FANCC FANCC ENSMMUP00000067421 ENSMMUP00000067421 USP1 USP1 ENSMMUP00000069269 ENSMMUP00000069269 ENSMMUP00000070235 ENSMMUP00000070235 NUTF2 NUTF2 FAN1 FAN1 FAAP100 FAAP100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS27A-2Ubiquitin-40S ribosomal protein S27a. (156 aa)
POLNDNA polymerase nu. (900 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MEIOBMeiosis specific with OB-fold. (550 aa)
FANCEFA complementation group E. (536 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
FANCMFA complementation group M. (2050 aa)
DCLRE1ADNA cross-link repair 1A. (1039 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
FANCBFA complementation group B. (858 aa)
FAAP24Fanconi anemia-associated protein of 24 kDa. (215 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
FANCFFanconi anemia group F protein. (374 aa)
F7DM39_MACMUUncharacterized protein. (143 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PROSER1Proline and serine rich 1. (942 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1668 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ATRIPATR-interacting protein isoform 1. (791 aa)
FANCIFA complementation group I. (1328 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
RPS27AUncharacterized protein. (156 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (437 aa)
KXD1KxDL domain-containing protein. (231 aa)
WDR48WD repeat domain 48. (745 aa)
FANCAFA complementation group A. (1462 aa)
UBCUncharacterized protein. (270 aa)
UBBUncharacterized protein. (229 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
FANCLFA complementation group L. (531 aa)
FANCD2Uncharacterized protein. (1471 aa)
CENPXUncharacterized protein. (201 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
ENSMMUP00000067421Ubiquitin-like domain-containing protein. (135 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
ENSMMUP00000069269Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
ENSMMUP00000070235Ubiquitin-like domain-containing protein. (110 aa)
NUTF2Nuclear transport factor 2. (127 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
FAAP100Fanconi anemia-associated protein of 100 kDa isoform b. (881 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.