(16 nodes) Regulation of TP53 Activity through Association with Co-factors network (Macaca mulatta)

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Your Input:
	C17orf113	Chromosome 17 open reading frame 113. (675 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PPP1R13L	Protein phosphatase 1 regulatory subunit 13 like. (828 aa)
	ZNF385B	Zinc finger protein 385B. (486 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
	BANP	BTG3 associated nuclear protein. (530 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1134 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1286 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	POU4F1	POU domain protein. (423 aa)
	PHF20	Hepatocellular carcinoma-associated antigen 58. (1012 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	AKT2	AKT serine/threonine kinase 2. (594 aa)
	ZNF385C	Zinc finger protein 385C. (534 aa)
	POU4F2	POU domain protein. (408 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSMMUP00000061388	ENSMMUP00000059674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2.	0.968
AKT1	AKT3	ENSMMUP00000061388	ENSMMUP00000026292	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.936
AKT1	PHF20	ENSMMUP00000061388	ENSMMUP00000037841	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Hepatocellular carcinoma-associated antigen 58.	0.504
AKT1	TP53	ENSMMUP00000061388	ENSMMUP00000011334	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.974
AKT1	TP53BP2	ENSMMUP00000061388	ENSMMUP00000014590	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor protein p53 binding protein 2.	0.432
AKT2	AKT1	ENSMMUP00000059674	ENSMMUP00000061388	AKT serine/threonine kinase 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.968
AKT2	AKT3	ENSMMUP00000059674	ENSMMUP00000026292	AKT serine/threonine kinase 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.940
AKT2	PHF20	ENSMMUP00000059674	ENSMMUP00000037841	AKT serine/threonine kinase 2.	Hepatocellular carcinoma-associated antigen 58.	0.490
AKT2	TP53	ENSMMUP00000059674	ENSMMUP00000011334	AKT serine/threonine kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.953
AKT3	AKT1	ENSMMUP00000026292	ENSMMUP00000061388	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.936
AKT3	AKT2	ENSMMUP00000026292	ENSMMUP00000059674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2.	0.940
AKT3	PHF20	ENSMMUP00000026292	ENSMMUP00000037841	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Hepatocellular carcinoma-associated antigen 58.	0.464
AKT3	TP53	ENSMMUP00000026292	ENSMMUP00000011334	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.940
BANP	TP53	ENSMMUP00000012390	ENSMMUP00000011334	BTG3 associated nuclear protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.755
BANP	TP63	ENSMMUP00000012390	ENSMMUP00000038274	BTG3 associated nuclear protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.529
BANP	TP73	ENSMMUP00000012390	ENSMMUP00000021769	BTG3 associated nuclear protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.529
C17orf113	TP53	ENSMMUP00000068663	ENSMMUP00000011334	Chromosome 17 open reading frame 113.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.486
PHF20	AKT1	ENSMMUP00000037841	ENSMMUP00000061388	Hepatocellular carcinoma-associated antigen 58.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.504
PHF20	AKT2	ENSMMUP00000037841	ENSMMUP00000059674	Hepatocellular carcinoma-associated antigen 58.	AKT serine/threonine kinase 2.	0.490
PHF20	AKT3	ENSMMUP00000037841	ENSMMUP00000026292	Hepatocellular carcinoma-associated antigen 58.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.464