(58 nodes) p53-Independent G1/S DNA damage checkpoint network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (454 aa)
	LOC699631	Proteasome subunit alpha type. (206 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMA1	Proteasome endopeptidase complex. (301 aa)
	ENSMMUP00000070235	Ubiquitin-like domain-containing protein. (110 aa)
	ENSMMUP00000069031	Uncharacterized protein. (158 aa)
	PSMB10	Proteasome subunit beta. (312 aa)
	ENSMMUP00000067421	Ubiquitin-like domain-containing protein. (135 aa)
	PSMD7	MPN domain-containing protein. (323 aa)
	PSMC6	AAA domain-containing protein; Belongs to the AAA ATPase family. (410 aa)
	PSMC5	26S protease regulatory subunit 8 isoform 1; Belongs to the AAA ATPase family. (406 aa)
	PSMA3	Proteasome subunit alpha type. (267 aa)
	PSMD8	CSN8_PSD8_EIF3K domain-containing protein. (364 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	PSME3	Proteasome activator subunit 3. (265 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	PSME2	Proteasome activator subunit 2. (248 aa)
	UBB	Uncharacterized protein. (229 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMB3	Proteasome subunit beta. (261 aa)
	UBC	Uncharacterized protein. (270 aa)
	KXD1	KxDL domain-containing protein. (231 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (253 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (442 aa)
	CHEK2	Checkpoint kinase 2. (539 aa)
	CHEK1	STT3 oligosaccharyltransferase complex catalytic subunit A. (768 aa)
	F7HHF9_MACMU	AAA domain-containing protein; Belongs to the AAA ATPase family. (352 aa)
	F7ALC4_MACMU	AAA domain-containing protein; Belongs to the AAA ATPase family. (360 aa)
	PSMC1	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
	CDC25A	M-phase inducer phosphatase 1 isoform a. (524 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMD3	26S proteasome non-ATPase regulatory subunit 3. (534 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	PSMC4	26S protease regulatory subunit 6B isoform 1; Belongs to the AAA ATPase family. (418 aa)
	PSMD9	26S proteasome non-ATPase regulatory subunit 9. (223 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	PSMC3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (439 aa)
	RPS27A-2	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	RPS27A	Uncharacterized protein. (156 aa)
	PSMB6	Proteasome subunit beta. (285 aa)
	PSME1	Proteasome activator complex subunit 1 isoform 1. (249 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMA4	Proteasome subunit alpha type. (300 aa)
	PSME4	Proteasome activator complex subunit 4. (1843 aa)
	PSMD4	VWFA domain-containing protein. (400 aa)
	PSMB11	Proteasome subunit beta. (243 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMF1	Proteasome inhibitor subunit 1. (288 aa)
	PSMC2	26S protease regulatory subunit 7 isoform 1; Belongs to the AAA ATPase family. (433 aa)
	PSMD5	26S proteasome non-ATPase regulatory subunit 5. (504 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (476 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25A	CHEK1	ENSMMUP00000027572	ENSMMUP00000036602	M-phase inducer phosphatase 1 isoform a.	STT3 oligosaccharyltransferase complex catalytic subunit A.	0.991
CDC25A	CHEK2	ENSMMUP00000027572	ENSMMUP00000037133	M-phase inducer phosphatase 1 isoform a.	Checkpoint kinase 2.	0.990
CDC25A	PSMD6	ENSMMUP00000027572	ENSMMUP00000039564	M-phase inducer phosphatase 1 isoform a.	Proteasome 26S subunit, non-ATPase 6.	0.402
CDC25A	PSME4	ENSMMUP00000027572	ENSMMUP00000010615	M-phase inducer phosphatase 1 isoform a.	Proteasome activator complex subunit 4.	0.478
CHEK1	CDC25A	ENSMMUP00000036602	ENSMMUP00000027572	STT3 oligosaccharyltransferase complex catalytic subunit A.	M-phase inducer phosphatase 1 isoform a.	0.991
CHEK1	CHEK2	ENSMMUP00000036602	ENSMMUP00000037133	STT3 oligosaccharyltransferase complex catalytic subunit A.	Checkpoint kinase 2.	0.990
CHEK2	CDC25A	ENSMMUP00000037133	ENSMMUP00000027572	Checkpoint kinase 2.	M-phase inducer phosphatase 1 isoform a.	0.990
CHEK2	CHEK1	ENSMMUP00000037133	ENSMMUP00000036602	Checkpoint kinase 2.	STT3 oligosaccharyltransferase complex catalytic subunit A.	0.990
ENSMMUP00000067421	ENSMMUP00000069031	ENSMMUP00000067421	ENSMMUP00000069031	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.703
ENSMMUP00000067421	F7ALC4_MACMU	ENSMMUP00000067421	ENSMMUP00000032903	Ubiquitin-like domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.698
ENSMMUP00000067421	F7HHF9_MACMU	ENSMMUP00000067421	ENSMMUP00000036049	Ubiquitin-like domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.678
ENSMMUP00000067421	KXD1	ENSMMUP00000067421	ENSMMUP00000043399	Ubiquitin-like domain-containing protein.	KxDL domain-containing protein.	0.513
ENSMMUP00000067421	LOC699631	ENSMMUP00000067421	ENSMMUP00000072634	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.696
ENSMMUP00000067421	PSMA1	ENSMMUP00000067421	ENSMMUP00000071183	Ubiquitin-like domain-containing protein.	Proteasome endopeptidase complex.	0.755
ENSMMUP00000067421	PSMA2	ENSMMUP00000067421	ENSMMUP00000053338	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.780
ENSMMUP00000067421	PSMA3	ENSMMUP00000067421	ENSMMUP00000059873	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.703
ENSMMUP00000067421	PSMA4	ENSMMUP00000067421	ENSMMUP00000014072	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.768
ENSMMUP00000067421	PSMA5	ENSMMUP00000067421	ENSMMUP00000079013	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.754
ENSMMUP00000067421	PSMA6	ENSMMUP00000067421	ENSMMUP00000048754	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.696
ENSMMUP00000067421	PSMA7	ENSMMUP00000067421	ENSMMUP00000024133	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.663