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| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (775 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1013 aa) |
| | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2899 aa) |
| | UBE2D3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38. (777 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa) |
| | CLIP4 | Uncharacterized protein. (710 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1597 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (709 aa) |
| | OTUD1 | OTU deubiquitinase 1. (480 aa) |
| | UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (657 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (841 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | SHARPIN | Sharpin. (382 aa) |
| | OMG | Oligodendrocyte-myelin glycoprotein. (440 aa) |
| | WDR31 | WD repeat domain 31. (368 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (356 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1245 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | RACK1 | Guanine nucleotide binding protein beta polypeptide 2-like 1. (317 aa) |
| | ARHGEF17 | Rho guanine nucleotide exchange factor 17. (2069 aa) |
| | MCF2L2 | MCF.2 cell line derived transforming sequence-like 2. (1114 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | SPATA2 | Spermatogenesis-associated protein PD1. (520 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10. (1345 aa) |
| | ARHGEF4 | Uncharacterized protein. (1924 aa) |
| | PSENEN | Gamma-secretase subunit PEN-2. (101 aa) |
| | ARHGEF18 | Uncharacterized protein. (1591 aa) |
| | PREX1 | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa) |
| | TNFRSF10C | Uncharacterized protein. (184 aa) |
| | ENSMMUP00000077392 | PA domain-containing protein. (123 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (562 aa) |
| | RTN4R | Reticulon 4 receptor. (538 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa) |
| | APH1B | Gamma-secretase subunit APH-1B isoform 1. (257 aa) |
| | RNF31 | Uncharacterized protein. (1146 aa) |
| | BIRC2 | Baculoviral IAP repeat-containing protein 2. (618 aa) |
| | CLIP3 | Cytoplasmic linker protein 170-related 59 kDa protein. (547 aa) |
| | OTULIN | Uncharacterized protein. (352 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (480 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (274 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (1128 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | MCF2L | MCF.2 cell line derived transforming sequence like. (1178 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | TGM3 | TGc domain-containing protein. (712 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | ENSMMUP00000071311 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (225 aa) |
| | SMPD5 | Uncharacterized protein. (381 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | ENSMMUP00000070235 | Ubiquitin-like domain-containing protein. (110 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | BAD | Bcl2 antagonist of cell death. (167 aa) |
| | TAX1BP1 | Uncharacterized protein. (800 aa) |
| | ENSMMUP00000067421 | Ubiquitin-like domain-containing protein. (135 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa) |
| | OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (593 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1277 aa) |
| | TGM6 | Transglutaminase 6. (706 aa) |
| | LOC707807 | DUF4203 domain-containing protein. (178 aa) |
| | SPPL2C | Signal peptide peptidase like 2C. (683 aa) |
| | RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 isoform 2. (510 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (410 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (535 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (961 aa) |
| | ARHGEF9 | Cdc42 guanine nucleotide exchange factor 9. (545 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3 isoform 1. (558 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (928 aa) |
| | TIAM1 | Uncharacterized protein. (1591 aa) |
| | TAB3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (712 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | LINGO1 | Leucine rich repeat and Ig domain containing 1. (614 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (931 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | PLEKHG2 | Pleckstrin homology and RhoGEF domain containing G2. (1387 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (289 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | CCDC71L | Coiled-coil domain containing 71 like. (235 aa) |
| | UBB | Uncharacterized protein. (229 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (211 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1025 aa) |
| | YWHAE | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1562 aa) |
| | ENSMMUP00000046952 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa) |
| | UBC | Uncharacterized protein. (270 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (416 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (294 aa) |
| | SOS2 | Uncharacterized protein. (1332 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33. (872 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1237 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40. (1761 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (184 aa) |
| | ECT2L | Epithelial cell transforming 2 like. (916 aa) |
| | ENSMMUP00000044229 | Uncharacterized protein. (900 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | KXD1 | KxDL domain-containing protein. (231 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (539 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1002 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3. (790 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1. (961 aa) |
| | ITSN1 | Intersectin 1. (1720 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | BEX3 | Uncharacterized protein. (236 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | ARHGEF39 | Vav-like protein C9orf100. (335 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (940 aa) |
| | OTUD7B | OTU domain-containing protein 7B. (843 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (737 aa) |
| | ECT2 | Epithelial cell transforming 2. (958 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (910 aa) |
| | NCSTN | Nicastrin. (720 aa) |
| | USP21 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (640 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (1131 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | FGD2 | FYVE, RhoGEF and PH domain containing 2. (655 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | F7FL02_MACMU | CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (166 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | TIAM2 | T cell lymphoma invasion and metastasis 2. (1701 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | SPPL2B | Uncharacterized protein. (518 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (1021 aa) |
| | RTN4 | Reticulon. (1193 aa) |
| | MAGED1 | MAGE family member D1. (834 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1155 aa) |
| | CISD1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | SESTD1 | SEC14 domain and spectrin repeat-containing protein 1. (696 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (655 aa) |
| | F6T365_MACMU | 14_3_3 domain-containing protein. (74 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | BCL2L11 | Uncharacterized protein. (292 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (675 aa) |
| | NET1 | Neuroepithelial cell-transforming gene 1 protein isoform 1. (596 aa) |
| | NSMAF | Uncharacterized protein. (920 aa) |
| | VAV2 | Guanine nucleotide exchange factor VAV2 isoform 1. (878 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | KALRN | Uncharacterized protein. (2987 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (471 aa) |
| | GNA13 | G protein subunit alpha 13. (409 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40. (128 aa) |
| | MADD | MAP kinase activating death domain. (1608 aa) |
| | RPS27A-2 | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3093 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | NGFR | Nerve growth factor receptor. (427 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19. (809 aa) |
| | F6S052_MACMU | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | RPS27A | Uncharacterized protein. (156 aa) |
| | BAG4 | BCL2 associated athanogene 4. (457 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
