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PLCG2 PLCG2 GNAI3 GNAI3 MAPK14 MAPK14 LOC694289 LOC694289 ADAM17 ADAM17 CYSLTR1 CYSLTR1 DPEP1 DPEP1 PRKAR2B PRKAR2B DPEP3 DPEP3 DPEP2 DPEP2 GNB5 GNB5 RHBDF2 RHBDF2 GNAI2 GNAI2 SRC SRC PRKACG PRKACG ADCY4 ADCY4 GNG5 GNG5 AHCYL1 AHCYL1 GNAI1 GNAI1 IL10 IL10 CREB1 CREB1 FCGR1A FCGR1A ITPR2 ITPR2 ITPR3 ITPR3 ADCY8 ADCY8 ITPR1 ITPR1 GNGT1 GNGT1 IL6 IL6 ADCY3 ADCY3 GNG11 GNG11 GNG3 GNG3 LYN LYN ADCY5 ADCY5 PLK2 PLK2 PRKACA PRKACA MYH9 MYH9 PLCG1 PLCG1 CD247 CD247 ADCY2 ADCY2 PRKACB PRKACB LOC700936 LOC700936 ADORA2B ADORA2B SYK SYK PRKX PRKX GNG4 GNG4 ADCY6 ADCY6 GGT1 GGT1 LOC106992273 LOC106992273 FGR FGR GNB1 GNB1 CYSLTR2 CYSLTR2 GNG7 GNG7 ADCY9 ADCY9 GGT5 GGT5 ADCY1 ADCY1 GNB2 GNB2 ADCY7 ADCY7 PRKAR1B PRKAR1B PRKAR1A PRKAR1A GNAT3 GNAT3 FYN FYN RHBDF1 RHBDF1 GNG13 GNG13 GNAZ GNAZ YES1 YES1 GNB4 GNB4 GNB3 GNB3 FURIN FURIN CD163 CD163 PRKAR2A PRKAR2A HCK HCK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC694289Uncharacterized protein. (394 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (470 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (513 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (490 aa)
GNB5G protein subunit beta 5. (395 aa)
RHBDF2Rhomboid 5 homolog 2. (827 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
SRCTyrosine-protein kinase. (644 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AHCYL1Putative adenosylhomocysteinase 2 isoform a; Belongs to the adenosylhomocysteinase family. (530 aa)
GNAI1G protein subunit alpha i1. (422 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
FCGR1AFCGRI variant 1. (357 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
LYNTyrosine-protein kinase. (577 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CD247CD247 molecule. (224 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
LOC700936Uncharacterized protein. (564 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
SYKTyrosine-protein kinase. (635 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (358 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
GGT1Uncharacterized protein. (569 aa)
LOC106992273Serine/threonine-protein kinase PRKX; Belongs to the protein kinase superfamily. (358 aa)
FGRTyrosine-protein kinase. (529 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
GGT5Gamma-glutamyltransferase 5. (586 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PRKAR1BCyclic nucleotide-binding domain-containing protein. (494 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
FYNTyrosine-protein kinase. (589 aa)
RHBDF1Rhomboid 5 homolog 1. (833 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GNAZGuanine nucleotide-binding protein G(Z) subunit alpha. (355 aa)
YES1Tyrosine-protein kinase. (543 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
CD163CD163 molecule. (1155 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
HCKTyrosine-protein kinase. (504 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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