(15 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Macaca mulatta)

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Your Input:
	ENSMMUP00000067421	Ubiquitin-like domain-containing protein. (135 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
	IRF7	Interferon regulatory factor 7. (504 aa)
	TLR9	TIR domain-containing protein. (1032 aa)
	RPS27A	Uncharacterized protein. (156 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	RPS27A-2	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	TRAF6	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (725 aa)
	UBC	Uncharacterized protein. (270 aa)
	UBB	Uncharacterized protein. (229 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	ENSMMUP00000070235	Ubiquitin-like domain-containing protein. (110 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMUP00000067421	TRAF6	ENSMMUP00000067421	ENSMMUP00000024012	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.752
ENSMMUP00000067421	UBA52	ENSMMUP00000067421	ENSMMUP00000021162	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40.	0.945
ENSMMUP00000067421	UBB	ENSMMUP00000067421	ENSMMUP00000050420	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.716
ENSMMUP00000067421	UBC	ENSMMUP00000067421	ENSMMUP00000046819	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.716
ENSMMUP00000067421	UBE2N	ENSMMUP00000067421	ENSMMUP00000051689	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.842
ENSMMUP00000070235	TRAF6	ENSMMUP00000070235	ENSMMUP00000024012	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.752
ENSMMUP00000070235	UBA52	ENSMMUP00000070235	ENSMMUP00000021162	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40.	0.942
ENSMMUP00000070235	UBB	ENSMMUP00000070235	ENSMMUP00000050420	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.709
ENSMMUP00000070235	UBC	ENSMMUP00000070235	ENSMMUP00000046819	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.709
ENSMMUP00000070235	UBE2N	ENSMMUP00000070235	ENSMMUP00000051689	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.842
IRAK1	IRAK4	ENSMMUP00000024614	ENSMMUP00000000286	Interleukin 1 receptor associated kinase 1.	Interleukin-1 receptor-associated kinase 4.	0.999
IRAK1	IRF7	ENSMMUP00000024614	ENSMMUP00000009317	Interleukin 1 receptor associated kinase 1.	Interferon regulatory factor 7.	0.971
IRAK1	MYD88	ENSMMUP00000024614	ENSMMUP00000001339	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IRAK1	TLR7	ENSMMUP00000024614	ENSMMUP00000018719	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.850
IRAK1	TLR9	ENSMMUP00000024614	ENSMMUP00000016086	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.750
IRAK1	TRAF6	ENSMMUP00000024614	ENSMMUP00000024012	Interleukin 1 receptor associated kinase 1.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.999
IRAK1	UBA52	ENSMMUP00000024614	ENSMMUP00000021162	Interleukin 1 receptor associated kinase 1.	Ubiquitin-60S ribosomal protein L40.	0.522
IRAK1	UBB	ENSMMUP00000024614	ENSMMUP00000050420	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.459
IRAK1	UBC	ENSMMUP00000024614	ENSMMUP00000046819	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.459
IRAK1	UBE2N	ENSMMUP00000024614	ENSMMUP00000051689	Interleukin 1 receptor associated kinase 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.735