(16 nodes) IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation network (Macaca mulatta)

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Your Input:
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
	UBC	Uncharacterized protein. (270 aa)
	UBB	Uncharacterized protein. (229 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	ENSMMUP00000067421	Ubiquitin-like domain-containing protein. (135 aa)
	ENSMMUP00000070235	Ubiquitin-like domain-containing protein. (110 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
	RPS27A	Uncharacterized protein. (156 aa)
	RPS27A-2	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	TRAF6	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (725 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	PELI2	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSMMUP00000067421	ENSMMUP00000043850	ENSMMUP00000067421	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.463
CHUK	ENSMMUP00000070235	ENSMMUP00000043850	ENSMMUP00000070235	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.463
CHUK	IKBKB	ENSMMUP00000043850	ENSMMUP00000032125	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	0.998
CHUK	IKBKG	ENSMMUP00000043850	ENSMMUP00000040739	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
CHUK	IRAK1	ENSMMUP00000043850	ENSMMUP00000024614	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin 1 receptor associated kinase 1.	0.980
CHUK	PELI1	ENSMMUP00000043850	ENSMMUP00000072501	Component of inhibitor of nuclear factor kappa B kinase complex.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.471
CHUK	PELI2	ENSMMUP00000043850	ENSMMUP00000080051	Component of inhibitor of nuclear factor kappa B kinase complex.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.464
CHUK	PELI3	ENSMMUP00000043850	ENSMMUP00000004509	Component of inhibitor of nuclear factor kappa B kinase complex.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.464
CHUK	RPS27A	ENSMMUP00000043850	ENSMMUP00000018279	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.463
CHUK	RPS27A-2	ENSMMUP00000043850	ENSMMUP00000020417	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-40S ribosomal protein S27a.	0.465
CHUK	TRAF6	ENSMMUP00000043850	ENSMMUP00000024012	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.987
CHUK	UBA52	ENSMMUP00000043850	ENSMMUP00000021162	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-60S ribosomal protein L40.	0.681
CHUK	UBB	ENSMMUP00000043850	ENSMMUP00000050420	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.500
CHUK	UBC	ENSMMUP00000043850	ENSMMUP00000046819	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.500
CHUK	UBE2N	ENSMMUP00000043850	ENSMMUP00000051689	Component of inhibitor of nuclear factor kappa B kinase complex.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.617
ENSMMUP00000067421	CHUK	ENSMMUP00000067421	ENSMMUP00000043850	Ubiquitin-like domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.463
ENSMMUP00000067421	IKBKB	ENSMMUP00000067421	ENSMMUP00000032125	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	0.434
ENSMMUP00000067421	IKBKG	ENSMMUP00000067421	ENSMMUP00000040739	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.633
ENSMMUP00000067421	TRAF6	ENSMMUP00000067421	ENSMMUP00000024012	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.752
ENSMMUP00000067421	UBA52	ENSMMUP00000067421	ENSMMUP00000021162	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40.	0.945