STRINGSTRING
FGF19 FGF19 IGF1 IGF1 FGF14 FGF14 IL13 IL13 FGFR4 FGFR4 LEP LEP CYP7A1 CYP7A1 VDR VDR BRCA2 BRCA2 FGF2 FGF2 TRPV5 TRPV5 KLB KLB FGF5 FGF5 FGF7 FGF7 FGF9 FGF9 FGF16 FGF16 FGF8 FGF8 PPARA PPARA KL KL FGF18 FGF18 FGFR3 FGFR3 FGFR1 FGFR1 HMGCS2 HMGCS2 PHEX PHEX FGF21 FGF21 INS INS NR1H4 NR1H4 GRB2 GRB2 FGFR2 FGFR2 STAT5A STAT5A FGF10 FGF10 GUSBA GUSBA SNCA SNCA PTH PTH IFNG IFNG SOS1 SOS1 BAD BAD FGF6 FGF6 CASP3 CASP3 FGF1 FGF1 GCG GCG FGF22 FGF22 GALNT3 GALNT3 PPARG PPARG FLRT3 FLRT3 FGF11 FGF11 FGF4 FGF4 FGF3 FGF3 FGF20 FGF20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
IGF1Insulin like growth factor 1. (208 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
FGFR4Fibroblast growth factor receptor. (859 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
VDRVitamin D receptor. (477 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (729 aa)
KLBKlotho beta. (1044 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
KLKlotho. (1014 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GUSBABeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (651 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BADBcl2 antagonist of cell death. (167 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GCGGlucagon. (263 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
FLRT3Fibronectin-like domain-containing leucine-rich transmembrane protein 3. (649 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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