34 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (198 aa)
	BAG3	Uncharacterized protein. (575 aa)
	RASSF5	Ras association domain family member 5. (418 aa)
	RASA1	RAS p21 protein activator 1. (1044 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
	PTEN	Uncharacterized protein. (589 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1208 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	C1QC	Complement C1q subcomponent subunit C. (245 aa)
	BNIP3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
	AMIGO2	Adhesion molecule with Ig like domain 2. (521 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	CEBPB	CCAAT/enhancer-binding protein. (344 aa)
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
	PXDN	Peroxidasin. (1533 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1. (350 aa)
	GJB6	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
	CLU	Clusterin; Belongs to the clusterin family. (489 aa)
	PXDNL	Peroxidasin like. (1428 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	TNNI3	Troponin T1, slow skeletal type. (443 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
	CRYAB	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (334 aa)
	LOC114674310	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
	C1QB	Complement C1q subcomponent subunit B. (253 aa)
	TXNIP	Thioredoxin-interacting protein. (391 aa)
	C4BPB	Complement component 4 binding protein beta. (252 aa)
	BHLHE40	Uncharacterized protein. (631 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	AMIGO2	ENSMMUP00000004947	ENSMMUP00000039895	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Adhesion molecule with Ig like domain 2.	0.474
ACVR1C	RASA1	ENSMMUP00000004947	ENSMMUP00000004328	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	RAS p21 protein activator 1.	0.421
AMIGO2	ACVR1C	ENSMMUP00000039895	ENSMMUP00000004947	Adhesion molecule with Ig like domain 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.474
AMIGO2	RASA1	ENSMMUP00000039895	ENSMMUP00000004328	Adhesion molecule with Ig like domain 2.	RAS p21 protein activator 1.	0.426
APOE	BCL2	ENSMMUP00000048554	ENSMMUP00000069881	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	BCL2 apoptosis regulator.	0.405
APOE	C1QB	ENSMMUP00000048554	ENSMMUP00000076042	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Complement C1q subcomponent subunit B.	0.412
APOE	C1QC	ENSMMUP00000048554	ENSMMUP00000027318	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Complement C1q subcomponent subunit C.	0.433
APOE	CASP3	ENSMMUP00000048554	ENSMMUP00000070295	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Caspase 3; Belongs to the peptidase C14A family.	0.513
APOE	CLU	ENSMMUP00000048554	ENSMMUP00000069256	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Clusterin; Belongs to the clusterin family.	0.916
APOE	PTEN	ENSMMUP00000048554	ENSMMUP00000011055	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Uncharacterized protein.	0.482
BAG3	BCL2	ENSMMUP00000001088	ENSMMUP00000069881	Uncharacterized protein.	BCL2 apoptosis regulator.	0.827
BAG3	CRYAB	ENSMMUP00000001088	ENSMMUP00000073819	Uncharacterized protein.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.704
BCL2	APOE	ENSMMUP00000069881	ENSMMUP00000048554	BCL2 apoptosis regulator.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.405
BCL2	BAG3	ENSMMUP00000069881	ENSMMUP00000001088	BCL2 apoptosis regulator.	Uncharacterized protein.	0.827
BCL2	BNIP3	ENSMMUP00000069881	ENSMMUP00000029538	BCL2 apoptosis regulator.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.996
BCL2	CASP3	ENSMMUP00000069881	ENSMMUP00000070295	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.955
BCL2	JUN	ENSMMUP00000069881	ENSMMUP00000074392	BCL2 apoptosis regulator.	Transcription factor AP-1; Belongs to the bZIP family.	0.688
BCL2	LOC114674310	ENSMMUP00000069881	ENSMMUP00000074775	BCL2 apoptosis regulator.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.962
BCL2	MCL1	ENSMMUP00000069881	ENSMMUP00000066060	BCL2 apoptosis regulator.	Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1.	0.621
BCL2	PTEN	ENSMMUP00000069881	ENSMMUP00000011055	BCL2 apoptosis regulator.	Uncharacterized protein.	0.693