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CPT1A CPT1A FDPS FDPS CALM3 CALM3 CALM2 CALM2 PSEN2 PSEN2 NPY NPY CASP3 CASP3 PRKCA PRKCA CPT2 CPT2 ACOX1 ACOX1 DHCR7 DHCR7 SYP SYP HMGCS1 HMGCS1 FDFT1 FDFT1 PCP4 PCP4 BDNF BDNF RELN RELN CALML3 CALML3 CALML6 CALML6 LOC717686 LOC717686 PSEN1 PSEN1 CALML5 CALML5 IDI1 IDI1 GAD1 GAD1 APP APP GAP43 GAP43 GAD2 GAD2 THY1 THY1 HMOX1 HMOX1 ACADM ACADM HMGCR HMGCR SST SST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (809 aa)
FDPSFarnesyl pyrophosphate synthase isoform a; Belongs to the FPP/GGPP synthase family. (419 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (169 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
CPT2Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
SYPSynaptophysin. (401 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
FDFT1Uncharacterized protein. (468 aa)
PCP4Purkinje cell protein 4. (62 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
RELNReelin. (3460 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
CALML6Calmodulin like 6. (181 aa)
LOC717686Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
CALML5Calmodulin-like protein 5. (146 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (228 aa)
GAD1Glutamate decarboxylase 1 isoform GAD67. (594 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
GAP43Growth associated protein 43. (238 aa)
GAD2Glutamate decarboxylase 2. (608 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (177 aa)
HMOX1Heme oxygenase 1. (288 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (454 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
SSTSomatostatin preproprotein. (116 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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