node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACADM | ACOX1 | ENSMMUP00000009469 | ENSMMUP00000067864 | Acyl-CoA dehydrogenase medium chain. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.742 |
ACADM | CPT1A | ENSMMUP00000009469 | ENSMMUP00000002371 | Acyl-CoA dehydrogenase medium chain. | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | 0.640 |
ACADM | CPT2 | ENSMMUP00000009469 | ENSMMUP00000069003 | Acyl-CoA dehydrogenase medium chain. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.770 |
ACADM | HMGCS1 | ENSMMUP00000009469 | ENSMMUP00000062864 | Acyl-CoA dehydrogenase medium chain. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.415 |
ACADM | IDI1 | ENSMMUP00000009469 | ENSMMUP00000022523 | Acyl-CoA dehydrogenase medium chain. | Isopentenyl-diphosphate delta isomerase 1. | 0.417 |
ACOX1 | ACADM | ENSMMUP00000067864 | ENSMMUP00000009469 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Acyl-CoA dehydrogenase medium chain. | 0.742 |
ACOX1 | CPT1A | ENSMMUP00000067864 | ENSMMUP00000002371 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | 0.800 |
ACOX1 | CPT2 | ENSMMUP00000067864 | ENSMMUP00000069003 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.976 |
ACOX1 | HMGCR | ENSMMUP00000067864 | ENSMMUP00000008068 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.444 |
ACOX1 | HMGCS1 | ENSMMUP00000067864 | ENSMMUP00000062864 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.465 |
APP | BDNF | ENSMMUP00000018894 | ENSMMUP00000059263 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.750 |
APP | CASP3 | ENSMMUP00000018894 | ENSMMUP00000070295 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Caspase 3; Belongs to the peptidase C14A family. | 0.677 |
APP | PSEN1 | ENSMMUP00000018894 | ENSMMUP00000032752 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.992 |
APP | PSEN2 | ENSMMUP00000018894 | ENSMMUP00000075513 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.962 |
APP | RELN | ENSMMUP00000018894 | ENSMMUP00000058310 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Reelin. | 0.456 |
APP | SST | ENSMMUP00000018894 | ENSMMUP00000001145 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Somatostatin preproprotein. | 0.456 |
APP | SYP | ENSMMUP00000018894 | ENSMMUP00000066003 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Synaptophysin. | 0.755 |
APP | THY1 | ENSMMUP00000018894 | ENSMMUP00000011701 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. | 0.617 |
BDNF | APP | ENSMMUP00000059263 | ENSMMUP00000018894 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.750 |
BDNF | CALM2 | ENSMMUP00000059263 | ENSMMUP00000076065 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Uncharacterized protein; Belongs to the calmodulin family. | 0.623 |