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CALM3 CALM3 GPX7 GPX7 BDNF BDNF SNCA SNCA HDAC5 HDAC5 GPX2 GPX2 CALML3 CALML3 GPX3 GPX3 UCP2 UCP2 HDAC7 HDAC7 NGF NGF CALML6 CALML6 LOC717686 LOC717686 GPX4 GPX4 INS INS SIRT1 SIRT1 IDH2 IDH2 PSEN1 PSEN1 NOS3 NOS3 GDNF GDNF CALML5 CALML5 IDH1 IDH1 GPX1 GPX1 SIRT3 SIRT3 FGF2 FGF2 HMOX1 HMOX1 CALB1 CALB1 HDAC4 HDAC4 LEP LEP GPX5 GPX5 GPX6 GPX6 LEPR LEPR CS CS IGF1 IGF1 GHRL GHRL RETNLB RETNLB GPX8 GPX8 NPY NPY RETN RETN MTOR MTOR HDAC9 HDAC9 ADIPOQ ADIPOQ CALM2 CALM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (991 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
CALML6Calmodulin like 6. (181 aa)
LOC717686Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SIRT1Sirtuin 1. (743 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
CALML5Calmodulin-like protein 5. (146 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
HMOX1Heme oxygenase 1. (288 aa)
CALB1Calbindin 1. (261 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
IGF1Insulin like growth factor 1. (208 aa)
GHRLGhrelin and obestatin prepropeptide. (222 aa)
RETNLBResistin like beta. (111 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (169 aa)
RETNUncharacterized protein. (248 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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