(16 nodes) (2013) Molecular mechanisms at the basis of plasticity in the developing visual cortex: epigenetic processes and gene programs. network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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gene neighborhood

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protein homology

Your Input:
	ENSMMUP00000068277	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC695427-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	PRMT8	Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
	NPAS4	Neuronal PAS domain protein 4. (802 aa)
	LOC699443	Histone H3; Belongs to the histone H3 family. (136 aa)
	LIMK1	LIM domain kinase 1 isoform 1. (647 aa)
	LOC710748	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC114669830	Histone H3; Belongs to the histone H3 family. (136 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	OTX2	Orthodenticle homeobox 2. (289 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC693939	Histone H3; Belongs to the histone H3 family. (136 aa)
	PVALB	Parvalbumin; Belongs to the parvalbumin family. (178 aa)
	SDF4	Stromal cell derived factor 4. (484 aa)
	LOC718280	Histone domain-containing protein. (136 aa)
	FOS	V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	ENSMMUP00000068277	ENSMMUP00000059263	ENSMMUP00000068277	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	FOS	ENSMMUP00000059263	ENSMMUP00000071593	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.788
BDNF	H3-4	ENSMMUP00000059263	ENSMMUP00000065118	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	LIMK1	ENSMMUP00000059263	ENSMMUP00000032130	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	LIM domain kinase 1 isoform 1.	0.558
BDNF	LOC114669830	ENSMMUP00000059263	ENSMMUP00000054943	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.489
BDNF	LOC693939	ENSMMUP00000059263	ENSMMUP00000068226	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	LOC695427-2	ENSMMUP00000059263	ENSMMUP00000001927	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	LOC699443	ENSMMUP00000059263	ENSMMUP00000021558	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	LOC710748	ENSMMUP00000059263	ENSMMUP00000051183	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone H3; Belongs to the histone H3 family.	0.472
BDNF	LOC718280	ENSMMUP00000059263	ENSMMUP00000068851	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Histone domain-containing protein.	0.472
BDNF	NPAS4	ENSMMUP00000059263	ENSMMUP00000021022	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neuronal PAS domain protein 4.	0.632
BDNF	OTX2	ENSMMUP00000059263	ENSMMUP00000063685	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Orthodenticle homeobox 2.	0.658
BDNF	PVALB	ENSMMUP00000059263	ENSMMUP00000068520	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Parvalbumin; Belongs to the parvalbumin family.	0.855
ENSMMUP00000068277	BDNF	ENSMMUP00000068277	ENSMMUP00000059263	Histone H3; Belongs to the histone H3 family.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.472
ENSMMUP00000068277	FOS	ENSMMUP00000068277	ENSMMUP00000071593	Histone H3; Belongs to the histone H3 family.	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.583
ENSMMUP00000068277	H3-4	ENSMMUP00000068277	ENSMMUP00000065118	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.461
ENSMMUP00000068277	LOC114669830	ENSMMUP00000068277	ENSMMUP00000054943	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.670
FOS	BDNF	ENSMMUP00000071593	ENSMMUP00000059263	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.788
FOS	ENSMMUP00000068277	ENSMMUP00000071593	ENSMMUP00000068277	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Histone H3; Belongs to the histone H3 family.	0.583
FOS	H3-4	ENSMMUP00000071593	ENSMMUP00000065118	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Histone H3; Belongs to the histone H3 family.	0.591