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MUS81 MUS81 EXOG EXOG RAD52 RAD52 PLK1 PLK1 FANCM FANCM LOC699443 LOC699443 PRIMPOL PRIMPOL TOP1 TOP1 APTX APTX SLX1A SLX1A UNG UNG PLK3 PLK3 RFC2 RFC2 BUB3 BUB3 LOC695427-2 LOC695427-2 GEN1 GEN1 ACO1 ACO1 LOC697721 LOC697721 ORC5 ORC5 LOC699110 LOC699110 LOC695323 LOC695323 LOC704341 LOC704341 PLK5 PLK5 LOC106996511-6 LOC106996511-6 LOC698354 LOC698354 LOC718280 LOC718280 LOC106996511-5 LOC106996511-5 ENSMMUP00000068277 ENSMMUP00000068277 LOC693939 LOC693939 RMI1 RMI1 LOC106996511-4 LOC106996511-4 LOC697115 LOC697115 LOC106996511-3 LOC106996511-3 H3-4 H3-4 DNA2 DNA2 PCNA PCNA LOC106996511-2 LOC106996511-2 MCM10 MCM10 LOC114669830 LOC114669830 GSR GSR PHF1 PHF1 PLK2 PLK2 LOC710748 LOC710748 BUB1 BUB1 RAD50 RAD50 LOC106996511 LOC106996511 MMS19 MMS19 MSH3 MSH3 LOC699317 LOC699317 OGG1 OGG1 EXO1 EXO1 RPS3 RPS3 RAD51 RAD51 MSH6 MSH6 DNTT DNTT TFAM TFAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
EXOGExo/endonuclease G. (397 aa)
RAD52RAD52 homolog, DNA repair protein. (442 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
FANCMFA complementation group M. (2050 aa)
LOC699443Histone H3; Belongs to the histone H3 family. (136 aa)
PRIMPOLPrimase and DNA directed polymerase. (593 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
APTXAprataxin isoform e. (356 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (437 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
PLK3Serine/threonine-protein kinase PLK. (664 aa)
RFC2Replication factor C subunit 2. (233 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (369 aa)
LOC695427-2Histone H3; Belongs to the histone H3 family. (136 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (918 aa)
ACO1Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (889 aa)
LOC697721Histone H4. (103 aa)
ORC5AAA_16 domain-containing protein. (450 aa)
LOC699110Histone H4. (103 aa)
LOC695323Histone H4. (103 aa)
LOC704341Histone H4. (103 aa)
PLK5Serine/threonine-protein kinase PLK. (625 aa)
LOC106996511-6Histone H4. (103 aa)
LOC698354Histone H4. (103 aa)
LOC718280Histone domain-containing protein. (136 aa)
LOC106996511-5Histone H4. (103 aa)
ENSMMUP00000068277Histone H3; Belongs to the histone H3 family. (136 aa)
LOC693939Histone H3; Belongs to the histone H3 family. (136 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
LOC106996511-4Histone H4. (103 aa)
LOC697115Histone H4. (103 aa)
LOC106996511-3Histone H4. (103 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
DNA2DNA replication helicase/nuclease 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC106996511-2Histone H4. (103 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (875 aa)
LOC114669830Histone H3; Belongs to the histone H3 family. (136 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (479 aa)
PHF1PHD finger protein 1 isoform b. (567 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
LOC710748Histone H3; Belongs to the histone H3 family. (136 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1085 aa)
RAD50Zinc-hook domain-containing protein. (1411 aa)
LOC106996511Histone H4. (103 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
LOC699317Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
OGG1ENDO3c domain-containing protein. (395 aa)
EXO1Exonuclease 1. (846 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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