STRINGSTRING
ERBB4 ERBB4 EGR2 EGR2 SLC1A5 SLC1A5 TACR3 TACR3 EGR1 EGR1 CALM3 CALM3 CALM2 CALM2 FOS FOS COMT COMT EGR4 EGR4 NRG1 NRG1 PRKACB PRKACB BDNF BDNF PRKACA PRKACA CALML3 CALML3 CALML6 CALML6 LOC717686 LOC717686 SLC1A6 SLC1A6 SLC1A2 SLC1A2 HTR2A HTR2A PRL PRL PRKACG PRKACG ARC ARC CYP2D42 CYP2D42 CALML5 CALML5 NPAS4 NPAS4 DISC1 DISC1 EGF EGF SLC1A7 SLC1A7 SLC1A3 SLC1A3 SLC6A1 SLC6A1 SLC6A11 SLC6A11 TH TH ALB ALB CYP3A4 CYP3A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
EGR2Uncharacterized protein. (489 aa)
SLC1A5Amino acid transporter. (542 aa)
TACR3NK-3 receptor; Belongs to the G-protein coupled receptor 1 family. (463 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
COMTCatechol-O-methyltransferase. (376 aa)
EGR4Early growth response 4. (588 aa)
NRG1Neuregulin 1. (700 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
CALML6Calmodulin like 6. (181 aa)
LOC717686Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
SLC1A6Amino acid transporter. (564 aa)
SLC1A2Amino acid transporter. (611 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (471 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (228 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
CYP2D42Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. (497 aa)
CALML5Calmodulin-like protein 5. (146 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
DISC1Uncharacterized protein. (885 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
SLC1A7Amino acid transporter. (619 aa)
SLC1A3Amino acid transporter. (549 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (632 aa)
THTyrosine hydroxylase. (501 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
CYP3A4Uncharacterized protein. (535 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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