30 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE1A	Phosphodiesterase. (570 aa)
	GUCY2C	Guanylate cyclase. (1073 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (194 aa)
	PDE1C	Phosphodiesterase. (793 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
	GUCY2D	Guanylate cyclase. (1145 aa)
	FOS	V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
	CREBBP	CREB-binding protein isoform a. (2442 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
	CALML3	Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
	PDE9A	Phosphodiesterase. (633 aa)
	CALML6	Calmodulin like 6. (181 aa)
	LOC717686	Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
	PDE1B	Phosphodiesterase. (538 aa)
	PDE7B	Phosphodiesterase. (505 aa)
	CDK5	Cyclin dependent kinase 5. (364 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	PRKACG	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	CALML5	Calmodulin-like protein 5. (146 aa)
	NPR2	Guanylate cyclase. (1047 aa)
	GUCY2F	Guanylate cyclase. (1108 aa)
	PDE4D	Phosphodiesterase. (809 aa)
	PDE7A	Phosphodiesterase. (527 aa)
	NPR1	Guanylate cyclase. (1061 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	TH	Tyrosine hydroxylase. (501 aa)
	RACK1	Guanine nucleotide binding protein beta polypeptide 2-like 1. (317 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	CALM2	ENSMMUP00000059263	ENSMMUP00000076065	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the calmodulin family.	0.623
BDNF	CALM3	ENSMMUP00000059263	ENSMMUP00000076991	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin 3; Belongs to the calmodulin family.	0.623
BDNF	CALML3	ENSMMUP00000059263	ENSMMUP00000053471	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin-related protein NB-1; Belongs to the calmodulin family.	0.622
BDNF	CALML5	ENSMMUP00000059263	ENSMMUP00000022969	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin-like protein 5.	0.623
BDNF	CALML6	ENSMMUP00000059263	ENSMMUP00000045683	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin like 6.	0.632
BDNF	CDK5	ENSMMUP00000059263	ENSMMUP00000026930	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Cyclin dependent kinase 5.	0.748
BDNF	CREBBP	ENSMMUP00000059263	ENSMMUP00000065708	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	CREB-binding protein isoform a.	0.724
BDNF	FOS	ENSMMUP00000059263	ENSMMUP00000071593	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.788
BDNF	LOC717686	ENSMMUP00000059263	ENSMMUP00000045604	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the calmodulin family.	0.623
BDNF	PRKACA	ENSMMUP00000059263	ENSMMUP00000054168	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.607
BDNF	PRKACB	ENSMMUP00000059263	ENSMMUP00000059748	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily.	0.608
BDNF	PRKACG	ENSMMUP00000059263	ENSMMUP00000026815	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	0.607
BDNF	SRC	ENSMMUP00000059263	ENSMMUP00000026506	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase.	0.606
BDNF	TH	ENSMMUP00000059263	ENSMMUP00000005218	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine hydroxylase.	0.880
CALM2	BDNF	ENSMMUP00000076065	ENSMMUP00000059263	Uncharacterized protein; Belongs to the calmodulin family.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.623
CALM2	CALM3	ENSMMUP00000076065	ENSMMUP00000076991	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin 3; Belongs to the calmodulin family.	0.904
CALM2	CALML3	ENSMMUP00000076065	ENSMMUP00000053471	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin-related protein NB-1; Belongs to the calmodulin family.	0.902
CALM2	CALML5	ENSMMUP00000076065	ENSMMUP00000022969	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin-like protein 5.	0.908
CALM2	CALML6	ENSMMUP00000076065	ENSMMUP00000045683	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 6.	0.904
CALM2	FOS	ENSMMUP00000076065	ENSMMUP00000071593	Uncharacterized protein; Belongs to the calmodulin family.	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.559