34 items (Macaca mulatta) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (772 aa)
	BARHL1	BarH like homeobox 1. (327 aa)
	PAX6	Uncharacterized protein. (598 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (194 aa)
	CDH7	Cadherin-7 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
	PTF1A	Pancreas associated transcription factor 1a. (329 aa)
	DRAXIN	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
	HOXA2	Homeobox A2. (374 aa)
	HOXA5	Homeobox A5. (381 aa)
	NTN1	Netrin 1. (604 aa)
	PHOX2B	Paired like homeobox 2B. (314 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (382 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	ROBO2	Roundabout guidance receptor 2. (1394 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (273 aa)
	HOXC5	Homeobox protein Hox-3D. (222 aa)
	CALML3	Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (566 aa)
	CALML6	Calmodulin like 6. (181 aa)
	LOC717686	Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	CALML5	Calmodulin-like protein 5. (146 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	GAP43	Growth associated protein 43. (238 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	UNC5C	Unc-5 netrin receptor C. (931 aa)
	UNC5B	Unc-5 netrin receptor B. (945 aa)
	ZIC1	Zic family member 1. (447 aa)
	ATOH1	Atonal bHLH transcription factor 1. (354 aa)
	CSDE1	Cold shock domain containing E1. (830 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	BARHL1	ENSMMUP00000003164	ENSMMUP00000080518	Atonal bHLH transcription factor 1.	BarH like homeobox 1.	0.706
ATOH1	GAP43	ENSMMUP00000003164	ENSMMUP00000016512	Atonal bHLH transcription factor 1.	Growth associated protein 43.	0.400
ATOH1	OLIG2	ENSMMUP00000003164	ENSMMUP00000023227	Atonal bHLH transcription factor 1.	Oligodendrocyte transcription factor 2.	0.472
ATOH1	OLIG3	ENSMMUP00000003164	ENSMMUP00000056763	Atonal bHLH transcription factor 1.	Oligodendrocyte transcription factor 3.	0.502
ATOH1	PAX6	ENSMMUP00000003164	ENSMMUP00000078205	Atonal bHLH transcription factor 1.	Uncharacterized protein.	0.621
ATOH1	PHOX2B	ENSMMUP00000003164	ENSMMUP00000067181	Atonal bHLH transcription factor 1.	Paired like homeobox 2B.	0.494
ATOH1	PTF1A	ENSMMUP00000003164	ENSMMUP00000074398	Atonal bHLH transcription factor 1.	Pancreas associated transcription factor 1a.	0.478
BARHL1	ATOH1	ENSMMUP00000080518	ENSMMUP00000003164	BarH like homeobox 1.	Atonal bHLH transcription factor 1.	0.706
BARHL1	PTF1A	ENSMMUP00000080518	ENSMMUP00000074398	BarH like homeobox 1.	Pancreas associated transcription factor 1a.	0.650
BDNF	CALM2	ENSMMUP00000059263	ENSMMUP00000076065	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the calmodulin family.	0.623
BDNF	CALM3	ENSMMUP00000059263	ENSMMUP00000076991	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin 3; Belongs to the calmodulin family.	0.623
BDNF	CALML3	ENSMMUP00000059263	ENSMMUP00000053471	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin-related protein NB-1; Belongs to the calmodulin family.	0.622
BDNF	CALML5	ENSMMUP00000059263	ENSMMUP00000022969	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin-like protein 5.	0.623
BDNF	CALML6	ENSMMUP00000059263	ENSMMUP00000045683	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calmodulin like 6.	0.632
BDNF	GAP43	ENSMMUP00000059263	ENSMMUP00000016512	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Growth associated protein 43.	0.696
BDNF	LOC717686	ENSMMUP00000059263	ENSMMUP00000045604	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the calmodulin family.	0.623
BDNF	NTN1	ENSMMUP00000059263	ENSMMUP00000067564	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Netrin 1.	0.451
BDNF	OLIG2	ENSMMUP00000059263	ENSMMUP00000023227	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Oligodendrocyte transcription factor 2.	0.618
BDNF	PAX6	ENSMMUP00000059263	ENSMMUP00000078205	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein.	0.568
BDNF	SEMA3A	ENSMMUP00000059263	ENSMMUP00000080596	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Semaphorin 3A; Belongs to the semaphorin family.	0.449