STRINGSTRING
PPIP5K2 PPIP5K2 HVCN1 HVCN1 VASH1 VASH1 PECAM1 PECAM1 PLIN3 PLIN3 CARNS1 CARNS1 MAP2K6 MAP2K6 HIF1A HIF1A MITF MITF C2CD5 C2CD5 PRKAG2 PRKAG2 EPAS1 EPAS1 CAMK2D CAMK2D UCP2 UCP2 EDNRB EDNRB MLXIPL MLXIPL PIK3C3 PIK3C3 TBC1D1 TBC1D1 TLR4 TLR4 ACVRL1 ACVRL1 SLC26A6 SLC26A6 NCOR2 NCOR2 INS INS LRP5 LRP5 EFNB2 EFNB2 TPK1 TPK1 MYOT MYOT SQSTM1 SQSTM1 MAP3K7 MAP3K7 ABCC8 ABCC8 FLT1 FLT1 CAMK2G CAMK2G ABCC9 ABCC9 PGAM1 PGAM1 PTK2B PTK2B HGF HGF NOTCH4 NOTCH4 ATP1A2 ATP1A2 THRSP THRSP NOTCH1 NOTCH1 WIF1 WIF1 SLC4A4 SLC4A4 PREX2 PREX2 CD248 CD248 PPARD PPARD MRVI1 MRVI1 IGFBP3 IGFBP3 MYOC MYOC KDR KDR DMD DMD TBX5 TBX5 CRHR2 CRHR2 LOC696959 LOC696959 EGF EGF BMPR2 BMPR2 GAPDH GAPDH LEP LEP RXFP1 RXFP1 LEPR LEPR THRA THRA MYL7 MYL7 GJA5 GJA5 FLNB FLNB EGLN3 EGLN3 PDP1 PDP1 PPP1R1B PPP1R1B ADRA1B ADRA1B PRKAB1 PRKAB1 NR3C2 NR3C2 SGK1 SGK1 RABIF RABIF UCN2 UCN2 ENG ENG PPARG PPARG GATA6 GATA6 CD36 CD36 USP20 USP20 PFKFB2 PFKFB2 SMARCD3 SMARCD3 RAMP1 RAMP1 MID1IP1 MID1IP1 ACKR3 ACKR3 EHBP1 EHBP1 TFPI TFPI HSPB2 HSPB2 PDGFB PDGFB DLL4 DLL4 ADM ADM EEF2K EEF2K IQGAP2 IQGAP2 RCOR2 RCOR2 KCNJ5 KCNJ5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1278 aa)
HVCN1Hydrogen voltage gated channel 1. (273 aa)
VASH1Uncharacterized protein. (447 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (834 aa)
PLIN3Perilipin; Belongs to the perilipin family. (474 aa)
CARNS1Carnosine synthase 1. (1208 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
C2CD5C2 calcium dependent domain containing 5. (1054 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
CAMK2DProtein kinase domain-containing protein. (687 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
MLXIPLMLX interacting protein like. (880 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa)
TBC1D1TBC1 domain family member 1. (1282 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SLC26A6Solute carrier family 26 member 6. (756 aa)
NCOR2Nuclear receptor corepressor 2. (2516 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
MYOTPolycystin 2 like 2, transient receptor potential cation channel. (851 aa)
SQSTM1Sequestosome 1. (440 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (314 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
NOTCH4Notch receptor 4. (1997 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
THRSPThyroid hormone responsive. (150 aa)
NOTCH1Notch receptor 1. (2556 aa)
WIF1WNT inhibitory factor 1. (445 aa)
SLC4A4Anion exchange protein. (1125 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1607 aa)
CD248C-type lectin domain-containing protein. (757 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform 1. (441 aa)
MRVI1Murine retrovirus integration site 1 homolog. (886 aa)
IGFBP3Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
MYOCMyocilin. (491 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
DMDUncharacterized protein. (3685 aa)
TBX5T-box transcription factor 5. (518 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
LOC696959Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
RXFP1Relaxin family peptide receptor 1. (783 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
THRAThyroid hormone receptor alpha. (486 aa)
MYL7Myosin light chain 7. (251 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
FLNBFilamin B. (2633 aa)
EGLN3Egl nine homolog 3. (239 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (562 aa)
PPP1R1BUncharacterized protein. (433 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
NR3C2Nuclear receptor subfamily 3 group C member 2. (984 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
RABIFRAB interacting factor. (179 aa)
UCN2Urocortin 2. (114 aa)
ENGEndoglin. (672 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
GATA6Transcription factor GATA-6. (595 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
USP20Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (914 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 isoform a. (505 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (533 aa)
RAMP1Uncharacterized protein. (204 aa)
MID1IP1Gastrulation-specific G12-like protein. (183 aa)
ACKR3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (385 aa)
EHBP1EH domain-binding protein 1 isoform 1. (1231 aa)
TFPITissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. (304 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
ADMAdrenomedullin. (211 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1596 aa)
RCOR2REST corepressor 2. (568 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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