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HMGA1 HMGA1 TLR5 TLR5 SUZ12 SUZ12 LOC695427-2 LOC695427-2 CLDN1 CLDN1 LTA LTA CTCF CTCF IL17C IL17C TLR2 TLR2 LOC699443 LOC699443 IL17RE IL17RE DHFR DHFR GDNF GDNF LOC695427 LOC695427 IL1B IL1B EGR1 EGR1 LOC100430668 LOC100430668 KIF1A KIF1A LOC708899 LOC708899 LOC693887 LOC693887 LOC703889 LOC703889 DHFR2 DHFR2 CD4 CD4 LOC698105 LOC698105 NRTN NRTN H3-4 H3-4 AKT1 AKT1 LOC704104 LOC704104 CD160 CD160 TNF TNF IL6 IL6 NGF NGF GFAP GFAP ICOS ICOS TLR4 TLR4 IL10 IL10 ATRX ATRX AKT3 AKT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMGA1High mobility group AT-hook 1. (450 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (831 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
LOC695427-2Histone H3; Belongs to the histone H3 family. (136 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (205 aa)
CTCFTranscriptional repressor CTCF isoform 1. (727 aa)
IL17CInterleukin 17C. (197 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LOC699443Histone H3; Belongs to the histone H3 family. (136 aa)
IL17REInterleukin 17 receptor E. (665 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
LOC695427Histone H3.1. (136 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
LOC100430668Histone H3.1. (136 aa)
KIF1AKinesin family member 1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1799 aa)
LOC708899Histone H3.3. (136 aa)
LOC693887Histone H3.3. (136 aa)
LOC703889Histone H3.1. (136 aa)
DHFR2DHFR domain-containing protein. (103 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
LOC698105Histone H3.1. (136 aa)
NRTNNeurturin preproprotein. (197 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC704104Histone domain-containing protein. (154 aa)
CD160CD160 molecule. (229 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
ICOSInducible T-cell costimulator. (199 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ATRXATRX chromatin remodeler. (2490 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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