STRINGSTRING
TRIM21 TRIM21 CCR5 CCR5 SLFN13 SLFN13 SAMHD1 SAMHD1 DDX10 DDX10 SERINC3 SERINC3 CD4 CD4 CASP1 CASP1 SOCS2 SOCS2 DDX18 DDX18 CXCR4 CXCR4 NCK1 NCK1 DDX31 DDX31 AIM2 AIM2 SYK SYK TNF TNF CPSF6 CPSF6 DCAF1 DCAF1 UBE2N UBE2N ERCC1 ERCC1 ELOC ELOC TRIM5 TRIM5 ELOB ELOB CUL5 CUL5 DDX55 DDX55 NCK2 NCK2 CDK1 CDK1 IRF3 IRF3 CD209 CD209 SIGLEC1 SIGLEC1 TLR3 TLR3 IL2 IL2 ATG5 ATG5 CGAS CGAS CUL4A CUL4A MUS81 MUS81 PLK1 PLK1 EME1 EME1 MAVS MAVS PPIA PPIA ERCC4 ERCC4 TLR8 TLR8 TLR7 TLR7 UBE2V2 UBE2V2 CUL4B CUL4B TP53 TP53 APOB APOB SLX4 SLX4 SLX1A SLX1A SUN2 SUN2 PQBP1 PQBP1 MNDA MNDA TLR6 TLR6 NUP153 NUP153 MYD88 MYD88 MCM2 MCM2 UBE2W UBE2W IL1B IL1B TLR1 TLR1 IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM21E3 ubiquitin-protein ligase TRIM21. (475 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
SLFN13Schlafen family member 13. (897 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
DDX10RNA helicase. (905 aa)
SERINC3Tumor differentially expressed protein 1. (473 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
DDX18RNA helicase. (670 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (382 aa)
NCK1Cytoplasmic protein. (377 aa)
DDX31RNA helicase. (770 aa)
AIM2Absent in melanoma 2. (343 aa)
SYKTyrosine-protein kinase. (635 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (588 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1576 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
ELOCElongin C; Belongs to the SKP1 family. (151 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (496 aa)
ELOBTranscription elongation factor B polypeptide 2 isoform a. (118 aa)
CUL5Cullin 5; Belongs to the cullin family. (1119 aa)
DDX55RNA helicase. (585 aa)
NCK2Cytoplasmic protein. (393 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
IRF3Interferon regulatory factor 3. (450 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
CGASCyclic GMP-AMP synthase. (573 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
MAVSMitochondrial antiviral-signaling protein isoform 1. (541 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1040 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
CUL4BCullin 4B; Belongs to the cullin family. (933 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
APOBApolipoprotein B. (4555 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1668 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (437 aa)
SUN2Sad1 and UNC84 domain containing 2. (800 aa)
PQBP1Polyglutamine binding protein 1. (286 aa)
MNDAGamma-interferon-inducible protein 16 isoform 2. (729 aa)
TLR6Toll-like receptor. (796 aa)
NUP153Uncharacterized protein. (1474 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
UBE2WUBIQUITIN_CONJUGAT_2 domain-containing protein. (267 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
TLR1Toll-like receptor. (786 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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