11 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	NLGN3	Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). (848 aa)
	SLC1A6	Amino acid transporter. (564 aa)
	SLC1A2	Amino acid transporter. (611 aa)
	SLC1A7	Amino acid transporter. (619 aa)
	SLC1A3	Amino acid transporter. (549 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	FYN	Tyrosine-protein kinase. (589 aa)
	SLC1A5	Amino acid transporter. (542 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	CASP3	ENSMMUP00000059263	ENSMMUP00000070295	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Caspase 3; Belongs to the peptidase C14A family.	0.710
BDNF	FYN	ENSMMUP00000059263	ENSMMUP00000080137	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase.	0.659
BDNF	SHH	ENSMMUP00000059263	ENSMMUP00000065431	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.731
CASP3	BDNF	ENSMMUP00000070295	ENSMMUP00000059263	Caspase 3; Belongs to the peptidase C14A family.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.710
CASP3	FYN	ENSMMUP00000070295	ENSMMUP00000080137	Caspase 3; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.424
CASP3	SHH	ENSMMUP00000070295	ENSMMUP00000065431	Caspase 3; Belongs to the peptidase C14A family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.495
FYN	BDNF	ENSMMUP00000080137	ENSMMUP00000059263	Tyrosine-protein kinase.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.659
FYN	CASP3	ENSMMUP00000080137	ENSMMUP00000070295	Tyrosine-protein kinase.	Caspase 3; Belongs to the peptidase C14A family.	0.424
SHH	BDNF	ENSMMUP00000065431	ENSMMUP00000059263	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.731
SHH	CASP3	ENSMMUP00000065431	ENSMMUP00000070295	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Caspase 3; Belongs to the peptidase C14A family.	0.495