(12 nodes) (2018) Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse. network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Your Input:
	ACHE	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. (848 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
	PXDNL	Peroxidasin like. (1428 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	TSC2	TSC complex subunit 2. (2057 aa)
	PTEN	Uncharacterized protein. (589 aa)
	LAMP1	Lysosomal associated membrane protein 1. (733 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (144 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	PXDN	Peroxidasin. (1533 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	PXDN	ENSMMUP00000063657	ENSMMUP00000061072	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Peroxidasin.	0.505
ACHE	PXDNL	ENSMMUP00000063657	ENSMMUP00000069678	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Peroxidasin like.	0.505
CD4	CSF2	ENSMMUP00000069370	ENSMMUP00000022240	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Granulocyte-macrophage colony-stimulating factor.	0.868
CD4	LAMP1	ENSMMUP00000069370	ENSMMUP00000012814	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Lysosomal associated membrane protein 1.	0.599
CD4	PTEN	ENSMMUP00000069370	ENSMMUP00000011055	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.450
CD4	PXDN	ENSMMUP00000069370	ENSMMUP00000061072	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Peroxidasin.	0.579
CD4	PXDNL	ENSMMUP00000069370	ENSMMUP00000069678	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Peroxidasin like.	0.775
CSF2	CD4	ENSMMUP00000022240	ENSMMUP00000069370	Granulocyte-macrophage colony-stimulating factor.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.868
CSF2	PDGFRB	ENSMMUP00000022240	ENSMMUP00000015166	Granulocyte-macrophage colony-stimulating factor.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.702
CSF2	PXDN	ENSMMUP00000022240	ENSMMUP00000061072	Granulocyte-macrophage colony-stimulating factor.	Peroxidasin.	0.515
CSF2	PXDNL	ENSMMUP00000022240	ENSMMUP00000069678	Granulocyte-macrophage colony-stimulating factor.	Peroxidasin like.	0.515
LAMP1	CD4	ENSMMUP00000012814	ENSMMUP00000069370	Lysosomal associated membrane protein 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.599
LAMP1	MTOR	ENSMMUP00000012814	ENSMMUP00000073444	Lysosomal associated membrane protein 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.937
LAMP1	PXDN	ENSMMUP00000012814	ENSMMUP00000061072	Lysosomal associated membrane protein 1.	Peroxidasin.	0.491
LAMP1	PXDNL	ENSMMUP00000012814	ENSMMUP00000069678	Lysosomal associated membrane protein 1.	Peroxidasin like.	0.487
MTOR	LAMP1	ENSMMUP00000073444	ENSMMUP00000012814	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Lysosomal associated membrane protein 1.	0.937
MTOR	PTEN	ENSMMUP00000073444	ENSMMUP00000011055	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.658
MTOR	TSC1	ENSMMUP00000073444	ENSMMUP00000012977	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1.	0.906
MTOR	TSC2	ENSMMUP00000073444	ENSMMUP00000003781	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 2.	0.925
PDGFRB	CSF2	ENSMMUP00000015166	ENSMMUP00000022240	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Granulocyte-macrophage colony-stimulating factor.	0.702