33 items (Macaca mulatta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	DRD5	D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
	DRD1	D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
	CHRNB4	Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
	ADRA2B	Adrenoceptor alpha 2B. (445 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	CHRNA4	Uncharacterized protein. (625 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	CHRM3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
	DRD3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
	CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit. (497 aa)
	ADRB3	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (418 aa)
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
	LOC719678	Uncharacterized protein. (626 aa)
	ADRA2C	Adrenoceptor alpha 2C. (458 aa)
	ADRA2A	Adrenoceptor alpha 2A. (465 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	ADRB1	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
	CHRNA6	Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
	CHRM4	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
	ADRA1A	Adrenoceptor alpha 1A. (445 aa)
	CHRNA2	Cholinergic receptor nicotinic alpha 2 subunit. (530 aa)
	CHRNB3	Neuronal acetylcholine receptor subunit beta-3. (458 aa)
	CHRM2	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (492 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
	CHRNB2	Neuronal acetylcholine receptor subunit beta-2. (502 aa)
	ADRA1B	Adrenoceptor alpha 1B. (518 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	ADRA1B	ENSMMUP00000054425	ENSMMUP00000080927	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1B.	0.943
ADRA1B	ADRA1A	ENSMMUP00000080927	ENSMMUP00000054425	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1A.	0.943
ADRA1B	CHRNA2	ENSMMUP00000080927	ENSMMUP00000057674	Adrenoceptor alpha 1B.	Cholinergic receptor nicotinic alpha 2 subunit.	0.467
ADRA1B	CHRNA4	ENSMMUP00000080927	ENSMMUP00000020935	Adrenoceptor alpha 1B.	Uncharacterized protein.	0.405
ADRA1B	CHRNA6	ENSMMUP00000080927	ENSMMUP00000048209	Adrenoceptor alpha 1B.	Cholinergic receptor nicotinic alpha 6 subunit.	0.431
ADRA1B	CHRNA9	ENSMMUP00000080927	ENSMMUP00000035318	Adrenoceptor alpha 1B.	Cholinergic receptor nicotinic alpha 9 subunit.	0.444
ADRA1B	CHRNB3	ENSMMUP00000080927	ENSMMUP00000063550	Adrenoceptor alpha 1B.	Neuronal acetylcholine receptor subunit beta-3.	0.485
ADRA2A	ADRA2B	ENSMMUP00000043965	ENSMMUP00000015538	Adrenoceptor alpha 2A.	Adrenoceptor alpha 2B.	0.434
ADRA2A	ADRB3	ENSMMUP00000043965	ENSMMUP00000032146	Adrenoceptor alpha 2A.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis.	0.403
ADRA2A	CHRNB3	ENSMMUP00000043965	ENSMMUP00000063550	Adrenoceptor alpha 2A.	Neuronal acetylcholine receptor subunit beta-3.	0.418
ADRA2B	ADRA2A	ENSMMUP00000015538	ENSMMUP00000043965	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2A.	0.434
ADRA2B	ADRA2C	ENSMMUP00000015538	ENSMMUP00000040736	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2C.	0.438
ADRA2B	ADRB3	ENSMMUP00000015538	ENSMMUP00000032146	Adrenoceptor alpha 2B.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis.	0.433
ADRA2C	ADRA2B	ENSMMUP00000040736	ENSMMUP00000015538	Adrenoceptor alpha 2C.	Adrenoceptor alpha 2B.	0.438
ADRA2C	CHRNA9	ENSMMUP00000040736	ENSMMUP00000035318	Adrenoceptor alpha 2C.	Cholinergic receptor nicotinic alpha 9 subunit.	0.473
ADRA2C	CHRNB3	ENSMMUP00000040736	ENSMMUP00000063550	Adrenoceptor alpha 2C.	Neuronal acetylcholine receptor subunit beta-3.	0.451
ADRB1	ADRB2	ENSMMUP00000048016	ENSMMUP00000002958	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.959
ADRB1	ADRB3	ENSMMUP00000048016	ENSMMUP00000032146	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis.	0.956
ADRB2	ADRB1	ENSMMUP00000002958	ENSMMUP00000048016	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.959
ADRB2	ADRB3	ENSMMUP00000002958	ENSMMUP00000032146	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis.	0.959