STRINGSTRING
BMP10 BMP10 DCN DCN BMP4 BMP4 IFNG IFNG SNAI1 SNAI1 TGFB2 TGFB2 SMAD5 SMAD5 TNF TNF SMAD2 SMAD2 SMAD3 SMAD3 TGFB1 TGFB1 LRG1 LRG1 SMAD4 SMAD4 FURIN FURIN TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP10Bone morphogenetic protein 10. (424 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (383 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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