28 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SLC1A5	Amino acid transporter. (542 aa)
	ARG2	Arginase. (417 aa)
	ARG1	Arginase. (322 aa)
	OAT	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa)
	LOC705256	Orn_Arg_deC_N domain-containing protein. (371 aa)
	SLC7A2	Solute carrier family 7 member 2. (658 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
	NPEPPS	Aminopeptidase. (921 aa)
	STAT1	Signal transducer and activator of transcription. (802 aa)
	ERAP2	Aminopeptidase. (947 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	ERAP1	Aminopeptidase. (941 aa)
	SLC1A6	Amino acid transporter. (564 aa)
	SLC1A2	Amino acid transporter. (611 aa)
	LVRN	Aminopeptidase. (990 aa)
	ODC1	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
	SLC3A2	4F2 cell-surface antigen heavy chain isoform c. (630 aa)
	LOC702037	Uncharacterized protein. (412 aa)
	ANPEP	Aminopeptidase. (966 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
	SLC1A7	Amino acid transporter. (619 aa)
	SLC1A3	Amino acid transporter. (549 aa)
	ENPEP	Aminopeptidase. (957 aa)
	ASS1	Argininosuccinate synthase. (412 aa)
	SLC7A7	Solute carrier family 7 member 7. (511 aa)
	GCH1	GTP cyclohydrolase 1. (250 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	SLC1A6	ENSMMUP00000019645	ENSMMUP00000042782	Aminopeptidase.	Amino acid transporter.	0.406
ARG1	ARG2	ENSMMUP00000075276	ENSMMUP00000077119	Arginase.	Arginase.	0.909
ARG1	ASS1	ENSMMUP00000075276	ENSMMUP00000002027	Arginase.	Argininosuccinate synthase.	0.513
ARG1	CSF1	ENSMMUP00000075276	ENSMMUP00000003609	Arginase.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.495
ARG1	IFNG	ENSMMUP00000075276	ENSMMUP00000065064	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.715
ARG1	IL4	ENSMMUP00000075276	ENSMMUP00000004188	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.793
ARG1	LOC702037	ENSMMUP00000075276	ENSMMUP00000025233	Arginase.	Uncharacterized protein.	0.453
ARG1	LOC705256	ENSMMUP00000075276	ENSMMUP00000067930	Arginase.	Orn_Arg_deC_N domain-containing protein.	0.962
ARG1	OAT	ENSMMUP00000075276	ENSMMUP00000069843	Arginase.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.996
ARG1	ODC1	ENSMMUP00000075276	ENSMMUP00000026911	Arginase.	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.964
ARG1	SLC7A2	ENSMMUP00000075276	ENSMMUP00000066759	Arginase.	Solute carrier family 7 member 2.	0.495
ARG1	STAT1	ENSMMUP00000075276	ENSMMUP00000057114	Arginase.	Signal transducer and activator of transcription.	0.452
ARG2	ARG1	ENSMMUP00000077119	ENSMMUP00000075276	Arginase.	Arginase.	0.909
ARG2	ASS1	ENSMMUP00000077119	ENSMMUP00000002027	Arginase.	Argininosuccinate synthase.	0.541
ARG2	IFNG	ENSMMUP00000077119	ENSMMUP00000065064	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.511
ARG2	IL4	ENSMMUP00000077119	ENSMMUP00000004188	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.541
ARG2	LOC702037	ENSMMUP00000077119	ENSMMUP00000025233	Arginase.	Uncharacterized protein.	0.470
ARG2	LOC705256	ENSMMUP00000077119	ENSMMUP00000067930	Arginase.	Orn_Arg_deC_N domain-containing protein.	0.963
ARG2	OAT	ENSMMUP00000077119	ENSMMUP00000069843	Arginase.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ARG2	ODC1	ENSMMUP00000077119	ENSMMUP00000026911	Arginase.	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.966