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AQP9 AQP9 MYD88 MYD88 TLR6 TLR6 FOXP1 FOXP1 STIM1 STIM1 MAFB MAFB CD44 CD44 PTPRJ PTPRJ IRF7 IRF7 TBK1 TBK1 ARFIP2 ARFIP2 LOC100426632 LOC100426632 TP53 TP53 CDK6 CDK6 WEE1 WEE1 INPP5D INPP5D NDRG1 NDRG1 SOCS1 SOCS1 PDGFRB PDGFRB E2F2 E2F2 TRIB3 TRIB3 RELB RELB MDM2 MDM2 CD69 CD69 WNT1 WNT1 NOTCH1 NOTCH1 JAG1 JAG1 TRAF6 TRAF6 DHFR DHFR IRAK1 IRAK1 AICDA AICDA SRC SRC CDC25A CDC25A DLL1 DLL1 CD209 CD209 IRF3 IRF3 CDK4 CDK4 CCNE2 CCNE2 TLR4 TLR4 CCL4L1 CCL4L1 STAT3 STAT3 E2F3 E2F3 NOTCH2 NOTCH2 RORA RORA S1PR1 S1PR1 IL6 IL6 POLE3 POLE3 CEBPB CEBPB PKN2 PKN2 TNF TNF STAT1 STAT1 IRAK3 IRAK3 MPZL1 MPZL1 CD47 CD47 DDIT4 DDIT4 IRAK2 IRAK2 IFNG IFNG DDX20 DDX20 DLL4 DLL4 CCL3 CCL3 PRKCI PRKCI ATF4 ATF4 IKBIP IKBIP CISH CISH CCL20 CCL20 CFLAR CFLAR GAS1 GAS1 TP53INP1 TP53INP1 AXIN2 AXIN2 CDKN1A CDKN1A LPIN1 LPIN1 TLR1 TLR1 IL13RA1 IL13RA1 IL1B IL1B CCND1 CCND1 SH2D4B SH2D4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP9Aquaporin-9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
TLR6Toll-like receptor. (796 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
STIM1Stromal interaction molecule 1. (684 aa)
MAFBMAF bZIP transcription factor B. (329 aa)
CD44Phagocytic glycoprotein I. (742 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1336 aa)
IRF7Interferon regulatory factor 7. (504 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
ARFIP2ADP-ribosylation factor-interacting protein 2. (341 aa)
LOC100426632C-C motif chemokine. (92 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa)
WEE1Wee1-like protein kinase. (646 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1208 aa)
NDRG1N-myc downstream regulated 1. (394 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
E2F2E2F transcription factor 2. (437 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CD69CD69 molecule. (204 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NOTCH1Notch receptor 1. (2556 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (725 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
SRCTyrosine-protein kinase. (644 aa)
CDC25AM-phase inducer phosphatase 1 isoform a. (524 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa)
IRF3Interferon regulatory factor 3. (450 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (426 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
CCL4L1C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (92 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
E2F3E2F transcription factor 3. (465 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
RORARAR related orphan receptor A. (555 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
PKN2Protein kinase N2. (981 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MPZL1Myelin protein zero-like protein 1 isoform a. (269 aa)
CD47CD47 molecule. (360 aa)
DDIT4Uncharacterized protein. (261 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (666 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
DDX20DEAD-box helicase 20. (878 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity). (92 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
ATF4BZIP domain-containing protein. (351 aa)
IKBIPIKBKB interacting protein. (379 aa)
CISHCytokine-inducible SH2-containing protein isoform 2. (258 aa)
CCL20C-C motif chemokine. (162 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (480 aa)
GAS1Growth arrest specific 1. (372 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform a. (241 aa)
AXIN2Axin 2. (862 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
LPIN1Lipin 1. (975 aa)
TLR1Toll-like receptor. (786 aa)
IL13RA1Uncharacterized protein. (437 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
SH2D4BTetraspanin. (375 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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