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AQP9 | Aquaporin-9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) | ||||
TLR6 | Toll-like receptor. (796 aa) | ||||
FOXP1 | Fork-head domain-containing protein. (695 aa) | ||||
STIM1 | Stromal interaction molecule 1. (684 aa) | ||||
MAFB | MAF bZIP transcription factor B. (329 aa) | ||||
CD44 | Phagocytic glycoprotein I. (742 aa) | ||||
PTPRJ | Protein tyrosine phosphatase receptor type J. (1336 aa) | ||||
IRF7 | Interferon regulatory factor 7. (504 aa) | ||||
TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) | ||||
ARFIP2 | ADP-ribosylation factor-interacting protein 2. (341 aa) | ||||
LOC100426632 | C-C motif chemokine. (92 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) | ||||
CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa) | ||||
WEE1 | Wee1-like protein kinase. (646 aa) | ||||
INPP5D | Inositol polyphosphate-5-phosphatase D. (1208 aa) | ||||
NDRG1 | N-myc downstream regulated 1. (394 aa) | ||||
SOCS1 | Suppressor of cytokine signaling 1. (215 aa) | ||||
PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) | ||||
E2F2 | E2F transcription factor 2. (437 aa) | ||||
TRIB3 | Tribbles pseudokinase 3. (385 aa) | ||||
RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) | ||||
CD69 | CD69 molecule. (204 aa) | ||||
WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) | ||||
NOTCH1 | Notch receptor 1. (2556 aa) | ||||
JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) | ||||
TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) | ||||
DHFR | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa) | ||||
IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) | ||||
AICDA | Activation induced cytidine deaminase. (198 aa) | ||||
SRC | Tyrosine-protein kinase. (644 aa) | ||||
CDC25A | M-phase inducer phosphatase 1 isoform a. (524 aa) | ||||
DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) | ||||
CD209 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa) | ||||
IRF3 | Interferon regulatory factor 3. (450 aa) | ||||
CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) | ||||
CCNE2 | Cyclin E2; Belongs to the cyclin family. (426 aa) | ||||
TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) | ||||
CCL4L1 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (92 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (871 aa) | ||||
E2F3 | E2F transcription factor 3. (465 aa) | ||||
NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) | ||||
RORA | RAR related orphan receptor A. (555 aa) | ||||
S1PR1 | Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) | ||||
POLE3 | DNA polymerase epsilon subunit 3. (147 aa) | ||||
CEBPB | CCAAT/enhancer-binding protein. (344 aa) | ||||
PKN2 | Protein kinase N2. (981 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) | ||||
STAT1 | Signal transducer and activator of transcription. (802 aa) | ||||
IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) | ||||
MPZL1 | Myelin protein zero-like protein 1 isoform a. (269 aa) | ||||
CD47 | CD47 molecule. (360 aa) | ||||
DDIT4 | Uncharacterized protein. (261 aa) | ||||
IRAK2 | Interleukin 1 receptor associated kinase 2. (666 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) | ||||
DDX20 | DEAD-box helicase 20. (878 aa) | ||||
DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa) | ||||
CCL3 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity). (92 aa) | ||||
PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) | ||||
ATF4 | BZIP domain-containing protein. (351 aa) | ||||
IKBIP | IKBKB interacting protein. (379 aa) | ||||
CISH | Cytokine-inducible SH2-containing protein isoform 2. (258 aa) | ||||
CCL20 | C-C motif chemokine. (162 aa) | ||||
CFLAR | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (480 aa) | ||||
GAS1 | Growth arrest specific 1. (372 aa) | ||||
TP53INP1 | Tumor protein p53-inducible nuclear protein 1 isoform a. (241 aa) | ||||
AXIN2 | Axin 2. (862 aa) | ||||
CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) | ||||
LPIN1 | Lipin 1. (975 aa) | ||||
TLR1 | Toll-like receptor. (786 aa) | ||||
IL13RA1 | Uncharacterized protein. (437 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) | ||||
CCND1 | Uncharacterized protein; Belongs to the cyclin family. (303 aa) | ||||
SH2D4B | Tetraspanin. (375 aa) |