STRINGSTRING
IL1B IL1B LPIN1 LPIN1 ARF1 ARF1 COL8A1 COL8A1 ITGB2 ITGB2 MSMO1 MSMO1 SC5D SC5D CASP3 CASP3 DDIT3 DDIT3 ANGPTL4 ANGPTL4 NSDHL NSDHL RPE65 RPE65 CASP1 CASP1 PDGFB PDGFB PLIN2 PLIN2 ABCA1 ABCA1 FDFT1 FDFT1 COL1A2 COL1A2 IGFBP5 IGFBP5 NCAM1 NCAM1 ADIPOQ ADIPOQ FGF10 FGF10 LDLR LDLR IL6 IL6 APOE APOE COL3A1 COL3A1 HSD17B7 HSD17B7 LAMA3 LAMA3 TLR4 TLR4 CD274 CD274 THBS3 THBS3 CLDN16 CLDN16 CASP8 CASP8 CDH3 CDH3 GSDMD GSDMD COL16A1 COL16A1 PDK4 PDK4 COL5A2 COL5A2 ACADS ACADS CREB3L1 CREB3L1 ACSS2 ACSS2 TNFRSF10A TNFRSF10A SLC25A20 SLC25A20 COL17A1 COL17A1 LAMC1 LAMC1 CAV1 CAV1 IGFBP3 IGFBP3 FLNA FLNA FASN FASN CDH10 CDH10 ACADVL ACADVL RHOJ RHOJ FLNC FLNC HMGCR HMGCR COL9A1 COL9A1 COL11A1 COL11A1 ITGA5 ITGA5 SQLE SQLE CPT1A CPT1A COL1A1 COL1A1 FLNB FLNB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
LPIN1Lipin 1. (975 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (217 aa)
COL8A1Collagen type VIII alpha 1 chain. (746 aa)
ITGB2Integrin beta. (911 aa)
MSMO1C-4 methylsterol oxidase isoform 1; Belongs to the sterol desaturase family. (293 aa)
SC5DLathosterol oxidase; Belongs to the sterol desaturase family. (299 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
ANGPTL4Angiopoietin like 4. (489 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (373 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
PLIN2Perilipin; Belongs to the perilipin family. (479 aa)
ABCA1ATP binding cassette subfamily A member 1. (2266 aa)
FDFT1Uncharacterized protein. (468 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
NCAM1Neural cell adhesion molecule 1. (1119 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LDLRUncharacterized protein. (918 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (341 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
CD274CD274 molecule. (299 aa)
THBS3Uncharacterized protein. (956 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
GSDMDGasdermin D. (529 aa)
COL16A1Collagen type XVI alpha 1 chain. (1604 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
ACADSUncharacterized protein. (415 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
ACSS2Uncharacterized protein. (714 aa)
TNFRSF10ATNF receptor superfamily member 10a. (471 aa)
SLC25A20Mitochondrial carnitine/acylcarnitine carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
COL17A1Collagen type XVII alpha 1 chain. (1455 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
CAV1Caveolin 1. (303 aa)
IGFBP3Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
FLNAFilamin-A isoform 2. (2647 aa)
FASNFatty acid synthase. (2576 aa)
CDH10Cadherin-10 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
FLNCFilamin C. (2725 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
COL11A1Collagen alpha-1(XI) chain isoform A preproprotein. (1806 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
SQLESqualene monooxygenase. (574 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (809 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
FLNBFilamin B. (2633 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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