STRINGSTRING
TLR6 TLR6 CD40 CD40 CD19 CD19 LTA LTA FCRL5 FCRL5 BCR BCR HERC3 HERC3 PTPN6 PTPN6 TSPAN33 TSPAN33 CLEC10A CLEC10A NFYB NFYB SNX13 SNX13 TLR10 TLR10 TNFSF13B TNFSF13B TLR4 TLR4 UBE3C UBE3C RAB40C RAB40C VSTM1 VSTM1 PTPN11 PTPN11 LYN LYN CD79B CD79B FCRL3 FCRL3 CD79A CD79A SMAD5 SMAD5 TNFRSF13C TNFRSF13C IFNG IFNG CD4 CD4 RUNX2 RUNX2 ZMIZ1 ZMIZ1 RUNX1 RUNX1 TLR1 TLR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR6Toll-like receptor. (796 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
CD19CD19 molecule. (557 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (205 aa)
FCRL5Fc receptor like 5. (1018 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
HERC3HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1050 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
TSPAN33Tetraspanin. (283 aa)
CLEC10AC-type lectin domain containing 10A. (287 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
SNX13Sorting nexin-13. (957 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
TNFSF13BTNF-and APOL-related leukocyte expressed ligand 1; Belongs to the tumor necrosis factor family. (285 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
UBE3CUbiquitin-protein ligase E3C. (1083 aa)
RAB40CRas-related protein Rab-40C isoform a. (281 aa)
VSTM1V-set and transmembrane domain containing 1. (236 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LYNTyrosine-protein kinase. (577 aa)
CD79BB-cell antigen receptor complex-associated protein beta chain isoform 3. (231 aa)
FCRL3Fc receptor like 3. (752 aa)
CD79ACD79a molecule. (225 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TNFRSF13CTNF receptor superfamily member 13C. (184 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1075 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
TLR1Toll-like receptor. (786 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (22%) [HD]