STRINGSTRING
MTOR MTOR FGF1 FGF1 TIRAP TIRAP CASP3 CASP3 DDIT3 DDIT3 BCL2 BCL2 ESR1 ESR1 FGF6 FGF6 BAD BAD GPX8 GPX8 SOS1 SOS1 SYP SYP SHH SHH PARVG PARVG SNCA SNCA BDNF BDNF TNF TNF GPX2 GPX2 FGF10 FGF10 CALML3 CALML3 UBL3 UBL3 GPX3 GPX3 FGF13 FGF13 DCX DCX IL6 IL6 NGF NGF SOS2 SOS2 ARC ARC ANGPT1 ANGPT1 CALML5 CALML5 TLR2 TLR2 FGF8 FGF8 APP APP GPX1 GPX1 EXOSC2 EXOSC2 FGF16 FGF16 FRS2 FRS2 FGF9 FGF9 FGF7 FGF7 FGF5 FGF5 BACE1 BACE1 FGF2 FGF2 FASLG FASLG XBP1 XBP1 RPL35 RPL35 GPX5 GPX5 GPX6 GPX6 ALB ALB IL4 IL4 FGF14 FGF14 MPO MPO IGF1 IGF1 MYD88 MYD88 GPX4 GPX4 TLR4 TLR4 TRIM45 TRIM45 SIRT1 SIRT1 GAB1 GAB1 POMT2 POMT2 LIMK1 LIMK1 FGF21 FGF21 ESR2 ESR2 FOXG1 FOXG1 NOS3 NOS3 SRC SRC GRB2 GRB2 FGF18 FGF18 LOC717686 LOC717686 CALML6 CALML6 HES3 HES3 FGF19 FGF19 FGF20 FGF20 FGF3 FGF3 IL1B IL1B FGF4 FGF4 FGF11 FGF11 GPX7 GPX7 EGR1 EGR1 CALM3 CALM3 MFAP2 MFAP2 FGF12 FGF12 CALM2 CALM2 FGF22 FGF22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BADBcl2 antagonist of cell death. (167 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
SYPSynaptophysin. (401 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PARVGParvin gamma. (402 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
UBL3Ubiquitin-like protein. (117 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
DCXDoublecortin. (387 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
SOS2Uncharacterized protein. (1332 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
ANGPT1Angiopoietin-1 isoform 1. (498 aa)
CALML5Calmodulin-like protein 5. (146 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
EXOSC2Exosome complex component RRP4. (293 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
XBP1X-box binding protein 1. (376 aa)
RPL3560S ribosomal protein L35. (123 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
MPOMyeloperoxidase. (745 aa)
IGF1Insulin like growth factor 1. (208 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
TRIM45Tripartite motif-containing protein 45 isoform 1. (580 aa)
SIRT1Sirtuin 1. (743 aa)
GAB1PH domain-containing protein. (790 aa)
POMT2Uncharacterized protein. (750 aa)
LIMK1LIM domain kinase 1 isoform 1. (647 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (530 aa)
FOXG1Forkhead box G1. (489 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SRCTyrosine-protein kinase. (644 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC717686Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
CALML6Calmodulin like 6. (181 aa)
HES3Hes family bHLH transcription factor 3. (178 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
MFAP2ShKT domain-containing protein. (183 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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