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MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa) | ||||
FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) | ||||
TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) | ||||
CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) | ||||
DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa) | ||||
BCL2 | BCL2 apoptosis regulator. (241 aa) | ||||
ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) | ||||
FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) | ||||
BAD | Bcl2 antagonist of cell death. (167 aa) | ||||
GPX8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa) | ||||
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa) | ||||
SYP | Synaptophysin. (401 aa) | ||||
SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) | ||||
PARVG | Parvin gamma. (402 aa) | ||||
SNCA | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa) | ||||
BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) | ||||
GPX2 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa) | ||||
FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) | ||||
CALML3 | Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa) | ||||
UBL3 | Ubiquitin-like protein. (117 aa) | ||||
GPX3 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa) | ||||
FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) | ||||
DCX | Doublecortin. (387 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) | ||||
NGF | Nerve growth factor; Belongs to the NGF-beta family. (294 aa) | ||||
SOS2 | Uncharacterized protein. (1332 aa) | ||||
ARC | Activity-regulated cytoskeleton-associated protein. (396 aa) | ||||
ANGPT1 | Angiopoietin-1 isoform 1. (498 aa) | ||||
CALML5 | Calmodulin-like protein 5. (146 aa) | ||||
TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) | ||||
FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) | ||||
APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa) | ||||
GPX1 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa) | ||||
EXOSC2 | Exosome complex component RRP4. (293 aa) | ||||
FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) | ||||
FRS2 | Fibroblast growth factor receptor substrate 2. (550 aa) | ||||
FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) | ||||
FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) | ||||
FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa) | ||||
BACE1 | Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa) | ||||
FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa) | ||||
FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) | ||||
XBP1 | X-box binding protein 1. (376 aa) | ||||
RPL35 | 60S ribosomal protein L35. (123 aa) | ||||
GPX5 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa) | ||||
GPX6 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa) | ||||
ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa) | ||||
IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa) | ||||
FGF14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa) | ||||
MPO | Myeloperoxidase. (745 aa) | ||||
IGF1 | Insulin like growth factor 1. (208 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) | ||||
GPX4 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa) | ||||
TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) | ||||
TRIM45 | Tripartite motif-containing protein 45 isoform 1. (580 aa) | ||||
SIRT1 | Sirtuin 1. (743 aa) | ||||
GAB1 | PH domain-containing protein. (790 aa) | ||||
POMT2 | Uncharacterized protein. (750 aa) | ||||
LIMK1 | LIM domain kinase 1 isoform 1. (647 aa) | ||||
FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) | ||||
ESR2 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (530 aa) | ||||
FOXG1 | Forkhead box G1. (489 aa) | ||||
NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa) | ||||
SRC | Tyrosine-protein kinase. (644 aa) | ||||
GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) | ||||
FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) | ||||
LOC717686 | Uncharacterized protein; Belongs to the calmodulin family. (105 aa) | ||||
CALML6 | Calmodulin like 6. (181 aa) | ||||
HES3 | Hes family bHLH transcription factor 3. (178 aa) | ||||
FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) | ||||
FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) | ||||
FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) | ||||
FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) | ||||
FGF11 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa) | ||||
GPX7 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa) | ||||
EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) | ||||
CALM3 | Calmodulin 3; Belongs to the calmodulin family. (194 aa) | ||||
MFAP2 | ShKT domain-containing protein. (183 aa) | ||||
FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) | ||||
CALM2 | Uncharacterized protein; Belongs to the calmodulin family. (204 aa) | ||||
FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |