STRINGSTRING
HDAC7 HDAC7 HLTF HLTF HDAC4 HDAC4 CUL4B CUL4B TET2 TET2 MUS81 MUS81 CUL4A CUL4A EXO1 EXO1 IL6 IL6 DCAF1 DCAF1 RBX1 RBX1 SIRT7 SIRT7 HDAC5 HDAC5 DDB1 DDB1 SAMHD1 SAMHD1 UBA1 UBA1 HDAC9 HDAC9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (991 aa)
HLTFHelicase like transcription factor. (1010 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
CUL4BCullin 4B; Belongs to the cullin family. (933 aa)
TET2Tet methylcytosine dioxygenase 2. (1999 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
EXO1Exonuclease 1. (846 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1576 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
SIRT7Sirtuin 7. (421 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
UBA1Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1064 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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