STRINGSTRING
HDAC9 HDAC9 NLGN2 NLGN2 MTOR MTOR GABRB3 GABRB3 GABRA1 GABRA1 WNT9B WNT9B DLX2 DLX2 PVALB PVALB SCN1B SCN1B HDAC5 HDAC5 CDKL5 CDKL5 BDNF BDNF UBE3A UBE3A FMR1 FMR1 LHX6 LHX6 RELN RELN GABRB1 GABRB1 MECP2 MECP2 SCN1A SCN1A DLX6 DLX6 HDAC7 HDAC7 NRXN1 NRXN1 PIK3C3 PIK3C3 CUL3 CUL3 BEST1 BEST1 CHD8 CHD8 GPHN GPHN NRXN2 NRXN2 BRD4 BRD4 WNT3 WNT3 AKT3 AKT3 SATB1 SATB1 CEP290 CEP290 CNTNAP2 CNTNAP2 WNT1 WNT1 GAD2 GAD2 SHANK1 SHANK1 PTEN PTEN NF1 NF1 HDAC4 HDAC4 SHANK3 SHANK3 FOXP1 FOXP1 TSC2 TSC2 SOX6 SOX6 SCN2A SCN2A ARID1B ARID1B IGF1 IGF1 PTCHD1 PTCHD1 SST SST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
NLGN2COesterase domain-containing protein. (836 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3 isoform 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
GABRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
DLX2Distal-less homeobox 2. (344 aa)
PVALBParvalbumin; Belongs to the parvalbumin family. (178 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (402 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
CDKL5Cyclin dependent kinase like 5. (1030 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
FMR1Fragile X mental retardation 1 protein isoform ISO1. (632 aa)
LHX6LIM homeobox 6. (392 aa)
RELNReelin. (3460 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
DLX6Distal-less homeobox 6. (292 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (991 aa)
NRXN1Uncharacterized protein. (1547 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa)
CUL3Cullin-3; Belongs to the cullin family. (768 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (604 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa)
GPHNGephyrin. (801 aa)
NRXN2Neurexin 2. (1713 aa)
BRD4Bromodomain containing 4. (1334 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SATB1DNA-binding protein SATB. (795 aa)
CEP290Centrosomal protein 290. (2480 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GAD2Glutamate decarboxylase 2. (608 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2163 aa)
PTENUncharacterized protein. (589 aa)
NF1Neurofibromin 1. (2867 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1730 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
TSC2TSC complex subunit 2. (2057 aa)
SOX6SRY-box 6. (828 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
ARID1BAT-rich interaction domain 1B. (2428 aa)
IGF1Insulin like growth factor 1. (208 aa)
PTCHD1Patched domain containing 1. (888 aa)
SSTSomatostatin preproprotein. (116 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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