STRINGSTRING
RPL31 RPL31 APLNR APLNR LOC714171 LOC714171 COL15A1 COL15A1 VASH2 VASH2 PGR PGR SERPING1 SERPING1 EIF4A1 EIF4A1 PRSS12 PRSS12 GRB14 GRB14 P2RX2 P2RX2 FIP1L1 FIP1L1 PRSS8 PRSS8 PDXK PDXK RPS29 RPS29 RPL37 RPL37 JUN JUN OVGP1 OVGP1 CD36 CD36 RTP3 RTP3 FGF1 FGF1 IGFBP6 IGFBP6 ESR1 ESR1 RAMP3 RAMP3 ABHD2 ABHD2 THBS2 THBS2 KLK11 KLK11 VASH1 VASH1 PAGR1 PAGR1 PECAM1 PECAM1 FXYD3 FXYD3 RARB RARB MGLL MGLL PRSS23 PRSS23 RPL37A RPL37A PRAP1 PRAP1 RPL38 RPL38 RPL36 RPL36 BTK BTK FCGR1A FCGR1A RPS28 RPS28 RPL39 RPL39 RPL23A RPL23A RPS26 RPS26 DCN DCN IGF1 IGF1 CRABP2 CRABP2 CSF1 CSF1 ALB ALB FCER1G FCER1G TRPM5 TRPM5 RPS21 RPS21 ASIC1 ASIC1 SERPINH1 SERPINH1 C3 C3 WT1 WT1 FGF9 FGF9 EGF EGF CD52 CD52 RPL19 RPL19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL31Uncharacterized protein. (128 aa)
APLNRApelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. P [...] (380 aa)
LOC71417160S ribosomal protein L31 isoform 1. (125 aa)
COL15A1Uncharacterized protein. (1578 aa)
VASH2Vasohibin 2. (355 aa)
PGRUncharacterized protein. (936 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (627 aa)
EIF4A1Eukaryotic initiation factor 4A-I isoform 1; Belongs to the DEAD box helicase family. (406 aa)
PRSS12Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family. (875 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (496 aa)
FIP1L1Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PRSS8Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (853 aa)
PDXKPyridoxal kinase. (312 aa)
RPS29Uncharacterized protein. (99 aa)
RPL37Ribosomal protein L37. (143 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
OVGP1Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (662 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
RTP3Receptor transporter protein 3. (232 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IGFBP6Insulin-like growth factor-binding protein 6. (239 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
RAMP3Uncharacterized protein. (172 aa)
ABHD2Abhydrolase domain-containing protein 2. (425 aa)
THBS2Thrombospondin 2. (1172 aa)
KLK11Kallikrein related peptidase 11; Belongs to the peptidase S1 family. (289 aa)
VASH1Uncharacterized protein. (447 aa)
PAGR1PAXIP1 associated glutamate rich protein 1. (254 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (834 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (144 aa)
RARBRetinoic acid receptor beta. (448 aa)
MGLLMonoglyceride lipase. (352 aa)
PRSS23Serine protease 23. (534 aa)
RPL37AUncharacterized protein. (120 aa)
PRAP1Uncharacterized protein. (149 aa)
RPL3860S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
RPL3660S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (105 aa)
BTKTyrosine-protein kinase. (659 aa)
FCGR1AFCGRI variant 1. (357 aa)
RPS2840S ribosomal protein S28. (69 aa)
RPL3960S ribosomal protein L39. (51 aa)
RPL23A60S ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family. (156 aa)
RPS2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
IGF1Insulin like growth factor 1. (208 aa)
CRABP2Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1156 aa)
RPS2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
ASIC1Amiloride-sensitive cation channel 2, neuronal isoform b; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (528 aa)
SERPINH1Serpin H1; Belongs to the serpin family. (418 aa)
C3Uncharacterized protein. (1663 aa)
WT1WT1 transcription factor. (517 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
CD52cAMPATH-1 antigen. (60 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (20%) [HD]