STRINGSTRING
KRAS KRAS DRD5 DRD5 GPR158 GPR158 PLCB1 PLCB1 EDF1 EDF1 TAF1 TAF1 NPC2 NPC2 CYC1 CYC1 SMC3 SMC3 GTF3A GTF3A GRIA3 GRIA3 GABRA4 GABRA4 GABRG2 GABRG2 GRM5 GRM5 TOP1 TOP1 GRM7 GRM7 ATP2B3 ATP2B3 CACNA1C CACNA1C YBX1 YBX1 CD63 CD63 ARHGEF7 ARHGEF7 ILF3 ILF3 KAT2A KAT2A CHRNA4 CHRNA4 GPR39 GPR39 GATA1 GATA1 SMAD4 SMAD4 PTPRO PTPRO CHRM3 CHRM3 KCNT1 KCNT1 KCND2 KCND2 ATP2B1 ATP2B1 GLRB GLRB HTR2A HTR2A NBEA NBEA LRP5 LRP5 LOC719678 LOC719678 PGK1 PGK1 DLG3 DLG3 ACTG1 ACTG1 UBE2D2 UBE2D2 GRIN2A GRIN2A KIRREL3 KIRREL3 GRM2 GRM2 UBTF UBTF ERC2 ERC2 SNAP25 SNAP25 KCNH1 KCNH1 CHRM2 CHRM2 HTR2C HTR2C ILF2 ILF2 KCNJ9 KCNJ9 ESR1 ESR1 GRIN2C GRIN2C GABRA1 GABRA1 MTOR MTOR TAF7 TAF7 RAD21 RAD21 ZMAT2 ZMAT2 NFE2L2 NFE2L2 EGR1 EGR1 GLRA2 GLRA2 SCN3B SCN3B GRM1 GRM1 SUZ12 SUZ12 POLE4 POLE4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (412 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
GPR158G protein-coupled receptor 158. (1214 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
EDF1Endothelial differentiation related factor 1. (161 aa)
TAF1Transcription initiation factor TFIID subunit. (1895 aa)
NPC2NPC intracellular cholesterol transporter 2. (151 aa)
CYC1Cytochrome c1. (325 aa)
SMC3Structural maintenance of chromosomes protein. (1196 aa)
GTF3AGeneral transcription factor IIIA. (461 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (554 aa)
GABRG2Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
GRM5Metabotropic glutamate receptor 5 isoform a. (1212 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
GRM7Glutamate metabotropic receptor 7. (915 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
CD63Tetraspanin. (238 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
ILF3Interleukin enhancer binding factor 3. (899 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
CHRNA4Uncharacterized protein. (625 aa)
GPR39G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (454 aa)
GATA1GATA binding protein 1. (413 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PTPROUncharacterized protein. (1216 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNT1Potassium sodium-activated channel subfamily T member 1. (1256 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
GLRBGlycine receptor subunit beta isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (471 aa)
NBEANeurobeachin. (2946 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
LOC719678Uncharacterized protein. (626 aa)
PGK1Phosphoglycerate kinase. (417 aa)
DLG3Uncharacterized protein; Belongs to the MAGUK family. (867 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (184 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (778 aa)
GRM2Metabotropic glutamate receptor 2 isoform a. (872 aa)
UBTFNucleolar transcription factor 1 isoform a. (764 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (1040 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1 isoform 2. (962 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (492 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
ILF2Uncharacterized protein. (411 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (468 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
GABRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
ZMAT2Zinc finger matrin-type 2. (305 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform 1. (606 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
SCN3BIg-like domain-containing protein. (240 aa)
GRM1Metabotropic glutamate receptor 1 isoform alpha. (1195 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
POLE4DNA polymerase epsilon subunit 4. (117 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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