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BDNF BDNF NEFM NEFM CALB1 CALB1 INA INA GAP43 GAP43 CAV1 CAV1 OTOF OTOF NTF4 NTF4 SYT4 SYT4 MYO7A MYO7A MAP2 MAP2 NTF3 NTF3 MBP MBP NGF NGF NTRK3 NTRK3 CACNA1D CACNA1D ATP1A3 ATP1A3 SNAP25 SNAP25 SYT2 SYT2 SYP SYP VAMP1 VAMP1 NTRK2 NTRK2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
NEFMNeurofilament medium; Belongs to the intermediate filament family. (919 aa)
CALB1Calbindin 1. (261 aa)
INAAlpha-internexin; Belongs to the intermediate filament family. (499 aa)
GAP43Growth associated protein 43. (238 aa)
CAV1Caveolin 1. (303 aa)
OTOFOtoferlin. (1996 aa)
NTF4NGF domain-containing protein; Belongs to the NGF-beta family. (210 aa)
SYT4Synaptotagmin IV. (425 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
MAP2Microtubule-associated protein. (1827 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
MBPMyelin basic protein. (437 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
SYT2Synaptotagmin 2. (470 aa)
SYPSynaptophysin. (401 aa)
VAMP1Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. (118 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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