STRINGSTRING
ATR ATR MTBP MTBP LOC697721 LOC697721 LOC699110 LOC699110 LOC699185 LOC699185 LOC695323 LOC695323 HTT HTT ENSMMUP00000072025 ENSMMUP00000072025 LOC704341 LOC704341 LOC106996511-6 LOC106996511-6 LOC698354 LOC698354 LOC106996511-5 LOC106996511-5 CREBBP CREBBP LOC106996511-4 LOC106996511-4 LOC697115 LOC697115 LOC106996511-3 LOC106996511-3 CDC6 CDC6 CDC7 CDC7 PIAS4 PIAS4 RIF1 RIF1 LOC106996511-2 LOC106996511-2 PALB2 PALB2 CDC45 CDC45 HDAC2 HDAC2 KMT5A KMT5A LMNB1 LMNB1 DDX1 DDX1 ERCC1 ERCC1 RAD50 RAD50 LOC106996511 LOC106996511 SUMO1 SUMO1 SCAI SCAI MAD2L2 MAD2L2 LOC699317 LOC699317 ASTE1 ASTE1 EXO1 EXO1 CDK1 CDK1 BRCA1 BRCA1 RAD51 RAD51 NIPBL NIPBL PARP1 PARP1 BLM BLM MUS81 MUS81 ERCC6 ERCC6 TP53BP1 TP53BP1 STN1 STN1 CDT1 CDT1 SHLD2 SHLD2 UHRF1 UHRF1 TERT TERT CTCF CTCF TP53 TP53 BRCA2 BRCA2 DBF4 DBF4 BARD1 BARD1 ZSCAN4 ZSCAN4 XRCC1 XRCC1 ATM ATM GPR83 GPR83 RNF168 RNF168 CTC1 CTC1 XRCC5 XRCC5 TICRR TICRR TOPBP1 TOPBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
MTBPMDM2 binding protein. (912 aa)
LOC697721Histone H4. (103 aa)
LOC699110Histone H4. (103 aa)
LOC699185Small ubiquitin-related modifier. (101 aa)
LOC695323Histone H4. (103 aa)
HTTHuntingtin. (3170 aa)
ENSMMUP00000072025Small ubiquitin-related modifier. (101 aa)
LOC704341Histone H4. (103 aa)
LOC106996511-6Histone H4. (103 aa)
LOC698354Histone H4. (103 aa)
LOC106996511-5Histone H4. (103 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
LOC106996511-4Histone H4. (103 aa)
LOC697115Histone H4. (103 aa)
LOC106996511-3Histone H4. (103 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (632 aa)
CDC7Cell division cycle 7-related protein kinase. (574 aa)
PIAS4Protein inhibitor of activated STAT 4. (561 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
LOC106996511-2Histone H4. (103 aa)
PALB2PALB2_WD40 domain-containing protein. (1205 aa)
CDC45Cell division cycle 45. (598 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
KMT5ALysine methyltransferase 5A. (352 aa)
LMNB1Lamin-B1 isoform 1; Belongs to the intermediate filament family. (586 aa)
DDX1ATP-dependent RNA helicase DDX1. (740 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
RAD50Zinc-hook domain-containing protein. (1411 aa)
LOC106996511Histone H4. (103 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
SCAIProtein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (629 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (212 aa)
LOC699317Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ASTE1Asteroid homolog 1. (704 aa)
EXO1Exonuclease 1. (846 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
NIPBLNipped-B protein. (2804 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
BLMBLM RecQ like helicase. (1416 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (2061 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
CDT1Chromatin licensing and DNA replication factor 1. (551 aa)
SHLD2FAM35_C domain-containing protein. (881 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (795 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
CTCFTranscriptional repressor CTCF isoform 1. (727 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
DBF4Protein DBF4 homolog A. (675 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (433 aa)
XRCC1X-ray repair cross complementing 1. (633 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
GPR83Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (778 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (661 aa)
CTC1CST telomere replication complex component 1. (1267 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1909 aa)
TOPBP1Uncharacterized protein. (1527 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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